A metalloproteomic analysis of interactions between plasma proteins and zinc: elevated fatty acid levels affect zinc distribution

Coverdale, James P. C.; Barnett, James P.; Adamu, Adamu H.; Griffiths, Ellie J.; Stewart, Alan J.; Blindauer, Claudia A.

doi:10.1039/c9mt00177h

Cited by 32 publications

(48 citation statements)

References 122 publications

(152 reference statements)

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“…Recent investigations by Coverdale et al [10] confirm and expand the knowledge on the impact of elevated concentrations of free fatty acids (FFAs) on the interactions between proteins, especially albumin and zinc. Physiologically relevant long-chain FFAs, for example, palmitate and stearate, have a higher affinity to albumin than zinc.…”

Section: Functions Of Zincmentioning

confidence: 88%

Zinc Deficiency—An Independent Risk Factor in the Pathogenesis of Haemorrhagic Stroke?

2020

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Zinc is an essential trace element for human health and plays a fundamental role in metabolic, immunological and many other biological processes. The effects of zinc are based on the intra- and extracellular regulatory function of the zinc ion (Zn2+) and its interactions with proteins. The regulation of cellular zinc homeostasis takes place via a complex network of metal transporters and buffering systems that react to changes in the availability of zinc in nutrition, chronic diseases, infections and many other processes. Zinc deficiency is associated with impairment of numerous metabolic processes, reduced resistance to infections due to impaired immune functions, changes in skin and its appendages and disorders of wound healing and haemostasis. While ischemic heart attacks (myocardial infarction) occur more frequently with meat-based normal diets, haemorrhagic strokes are more frequently observed with vegetarian/vegan diets. The causes are discussed as deficiencies of various micronutrients, such as vitamin B12, vitamin D, various amino acids and also zinc. In the present review, after a description of the functions of zinc and its resorption, a discussion of daily food intake will follow, with a special focus on the importance of food composition and preparation for the zinc balance. The close interrelationships between proteins, especially albumin and zinc will be discussed. Finally, the possible causes and consequences of a zinc deficiency on the blood vessels and blood coagulation are considered.

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Section: Functions Of Zincmentioning

confidence: 88%

Zinc Deficiency—An Independent Risk Factor in the Pathogenesis of Haemorrhagic Stroke?

2020

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“…HSA is the most abundant of all plasma proteins (60%) and is a water-soluble globular protein present at 35-50 g protein/L of human serum. It has an average halflife of 19 days and helps to regulate the blood pH and maintain the colloidal osmotic blood pressure [25]. Serum albumin binds Ni(II), Cu(II), Zn(II), and Ca(II) and also functions as a transport vehicle for these metal ions in the blood [25].…”

Section: Human Serum Albuminmentioning

confidence: 99%

Albumin and functionalized albumin nanoparticles: production strategies, characterization, and target indications

Srivastava

Prajapati

2020

Asian Biomedicine

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The inherent properties of albumin facilitate its effective use as a raw material to prepare a nanosized drug delivery vehicles. Because of the enhanced surface area, biocompatibility, and extended half-life of albumin nanoparticles, a number of drugs have been incorporated in albumin matrices in recent years. Furthermore, its ability to be conjugated to various receptor ligands makes albumin an ideal candidate for the increased delivery of drugs to specific sites. The present review provides an in-depth discussion of production strategies for the preparation of albumin and conjugated albumin nanoparticles and for the targeting of these formulations to specific organs and cancer cells. This review also provides insights into drug loading, release patterns, and cytotoxicity of various drug-loaded albumin nanoparticles.

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“…Thus, when pathological concentrations of FFAs are present in the blood, such as is the case in T2DM and in some cases of T1DM, Zn 2+ handling/buffering by serum albumin is dysregulated and plasma zinc speciation (the molecules to which it is bound) is altered [86]. Recently we have shown using size-exclusion-chromatography-ICP-MS that Zn 2+ is redistributed among other plasma proteins in the presence of pathophysiological FFA concentrations [87]. Considering the many coagulatory proteins that are regulated by Zn 2+ , this altered zinc speciation can dysregulate coagulation, resulting in increased platelet aggregation, increased fibrin clot density, and delayed fibrinolysis, thus potentially participating in the elevated thrombotic risks found in T2DM [86].…”

Section: Changes In Metal Ion Homeostasismentioning

confidence: 99%

Coagulatory Defects in Type-1 and Type-2 Diabetes

Sobczak

Stewart

2019

IJMS

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Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of death for individuals with diabetes is cardiovascular diseases, in part since both types of diabetes lead to physiological changes that affect haemostasis. Those changes include altered concentrations of coagulatory proteins, hyper-activation of platelets, changes in metal ion homeostasis, alterations in lipid metabolism (leading to lipotoxicity in the heart and atherosclerosis), the presence of pro-coagulatory microparticles and endothelial dysfunction. In this review, we explore the different mechanisms by which diabetes leads to an increased risk of developing coagulatory disorders and how this differs between type-1 and type-2 diabetes.

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A metalloproteomic analysis of interactions between plasma proteins and zinc: elevated fatty acid levels affect zinc distribution

Abstract: Serum albumin is the major zinc carrier in blood plasma. Fatty acid binding to albumin regulates its zinc-binding ability and alters plasma zinc speciation.

Cited by 32 publications

References 122 publications

Zinc Deficiency—An Independent Risk Factor in the Pathogenesis of Haemorrhagic Stroke?

Zinc Deficiency—An Independent Risk Factor in the Pathogenesis of Haemorrhagic Stroke?

Albumin and functionalized albumin nanoparticles: production strategies, characterization, and target indications

Coagulatory Defects in Type-1 and Type-2 Diabetes

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