A metabonomic evaluation of the monocrotaline-induced sinusoidal obstruction syndrome (SOS) in rats

Conotte, R.; Colet, Jean‐Marie

doi:10.1016/j.taap.2014.02.008

Cited by 19 publications

(13 citation statements)

References 32 publications

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“…Acetate is an endogenous metabolite of β -oxidation of fatty acids in liver. Its increased level in urine can be explained by the metabolization of acetyl-CoA that is produced by the β -oxidation of fatty acids [51]. The concomitant increase of taurine and creatine may reflect liver lesions such as necrosis [52].…”

Section: Discussionmentioning

confidence: 99%

Hepatic and Renal Toxicity Induced by TiO₂ Nanoparticles in Rats: A Morphological and Metabonomic Study

Valentini

Rugira

Frau

et al. 2019

Journal of Toxicology

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Titanium dioxide (TiO2) nanoparticles (NPs) are produced abundantly and are frequently used as a white pigment in the manufacture of paints, foods, paper, and toothpaste. Despite the wide ranges of uses, there is a lack of information on the impact of NPs on animal and human health. In the present study, rats were exposed to different doses of TiO2 nanoparticles and sacrificed, respectively, 4 days, 1 month, and 2 months after treatment. Dosage of TiO2 in tissues was performed by ICP-AES and revealed an important accumulation of TiO2 in the liver. The nanoparticles induced morphological and physiological alterations in liver and kidney. In the liver, these alterations mainly affect the hepatocytes located around the centrilobular veins. These cells were the site of an oxidative stress evidenced by immunocytochemical detection of 4-hydroxynonenal (4-HNE). Kupffer cells are also the site of an important oxidative stress following the massive internalization of TiO2 nanoparticles. Enzymatic markers of liver and kidney functions (such as AST and uric acid) are also disrupted only in animals exposed to highest doses. The metabonomic approach allowed us to detect modifications in urine samples already detectable after 4 days in animals treated at the lowest dose. This metabonomic pattern testifies an oxidative stress as well as renal and hepatic alterations.

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Section: Discussionmentioning

confidence: 99%

Hepatic and Renal Toxicity Induced by TiO₂ Nanoparticles in Rats: A Morphological and Metabonomic Study

Valentini

Rugira

Frau

et al. 2019

Journal of Toxicology

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“…Among them, high-resolution LC-MS is a promising tool for generating metabolomics data that can enable identification of potential biomarkers involved in drug-induced toxicity . Various potential biomarkers were identified and proposed to aid in the prediction of hepatotoxicity and nephrotoxicity caused by acetaminophen (Chen et al, 2009), gemfibrozil , isoniazid (Cheng et al, 2013), monocrotaline (Conotte and Colet, 2014), and flutamide (Choucha Snouber et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Increased serum bile acid concentration following low-dose chronic administration of thioacetamide in rats, as evidenced by metabolomic analysis

Jeong

Kim

Shin

et al. 2015

Toxicology and Applied Pharmacology

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“…Diet alters only steatotic changes in the liver and does not alter SOS features (Vetelainen et al , 2007). Only a diet, specifically deficient in one or more of the essential amino acids, limits monocrotaline-induced SOS in rats (Conotte and Colet, 2014). Robinson et al (2013a, 2013b) did not administer such a diet.…”

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confidence: 99%

Comment on ‘The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome’

et al. 2016

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A metabonomic evaluation of the monocrotaline-induced sinusoidal obstruction syndrome (SOS) in rats

Cited by 19 publications

References 32 publications

Hepatic and Renal Toxicity Induced by TiO₂ Nanoparticles in Rats: A Morphological and Metabonomic Study

Hepatic and Renal Toxicity Induced by TiO₂ Nanoparticles in Rats: A Morphological and Metabonomic Study

Increased serum bile acid concentration following low-dose chronic administration of thioacetamide in rats, as evidenced by metabolomic analysis

Comment on ‘The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome’

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A metabonomic evaluation of the monocrotaline-induced sinusoidal obstruction syndrome (SOS) in rats

Cited by 19 publications

References 32 publications

Hepatic and Renal Toxicity Induced by TiO2 Nanoparticles in Rats: A Morphological and Metabonomic Study

Hepatic and Renal Toxicity Induced by TiO2 Nanoparticles in Rats: A Morphological and Metabonomic Study

Increased serum bile acid concentration following low-dose chronic administration of thioacetamide in rats, as evidenced by metabolomic analysis

Comment on ‘The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome’

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Hepatic and Renal Toxicity Induced by TiO₂ Nanoparticles in Rats: A Morphological and Metabonomic Study

Hepatic and Renal Toxicity Induced by TiO₂ Nanoparticles in Rats: A Morphological and Metabonomic Study