2013
DOI: 10.1016/j.ecoenv.2012.02.022
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A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities

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Cited by 49 publications
(24 citation statements)
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“…In addition, the depleted lactate displayed the reduced anaerobiosis in the shrimps from LZB site. In arsenate-exposed clam R. philippinarum, the similar alteration of BCAAs and tyrosine was also observed (Wu et al, 2013b). Since the shrimp samples from LZB site were contaminated by arsenic, these amino acids could be used as biomarkers of arsenic contamination in shrimp C. affinis.…”
Section: H Nmrmentioning
confidence: 72%
“…In addition, the depleted lactate displayed the reduced anaerobiosis in the shrimps from LZB site. In arsenate-exposed clam R. philippinarum, the similar alteration of BCAAs and tyrosine was also observed (Wu et al, 2013b). Since the shrimp samples from LZB site were contaminated by arsenic, these amino acids could be used as biomarkers of arsenic contamination in shrimp C. affinis.…”
Section: H Nmrmentioning
confidence: 72%
“…Although there are several data about the effects of the environmental stress on the clam metabolism, the adaptation to the salinity change has remained largely unknown (Liu et al, 2011;Zhang et al, 2011aZhang et al, ,2011bZhang et al, ,2011cWu et al, 2013). The bivalves change ion and intracellular free amino acid concentrations to maintain inorganic ion strength (Pierce and Amende, 1981;Pierce, 1982).…”
Section: Introductionmentioning
confidence: 99%
“…Among these analytical techniques, 1 H NMR spectroscopy has received much attention for its advantages upon the simultaneous analysis of the low molecularweight metabolites in a short time Lindon et al, 2000;Picone et al, 2011). NMR-based metabolomics has been widely applied in multiple areas including biology (Nicholson et al, 1999), medicine (Dunn et al, 2011), toxicology (Kokushi et al, 2010;Li et al, 2006;Williams et al, 2009Williams et al, , 2011Williams et al, , 2014Wang, 2010, 2011;Wu et al, 2013bWu et al, , 2013c, immunology (Liu et al, , 2014 and nutriology (Collino et al, 2011). Regarding the temperature modulated marine organism, studies at the metabolic level have also been carried out in certain marine animals.…”
Section: Introductionmentioning
confidence: 99%