A Metabolic Bed for Collecting Excreta in Premature Infants

Cl, Kien

doi:10.1097/00005176-199005000-00011

Cited by 2 publications

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“…Isotopes , St. Louis, MO, U .S.A. ) and carmine red were administered at th e time th e infa nt was plac ed on a met aboli c bed (11). (c) Days 1-5: fecal co llection according to previou sly described techniques [except that effort was made to se pa ra te urine from fec e s (5 ,7)] .…”

Section: Experimental Designmentioning

confidence: 99%

Comparison of Methods for Estimating Fecal Carbohydrate Excretion in Premature Infants

Kien,

McClead,

Kepner

et al. 1993

J. pediatr. gastroenterol. nutr.

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SummaryOur previous studies have suggested that there is minimal fecal excretion of carbohydrate‐derived energy in premature infants fed lactose or glucose‐polymer as the source of carbohydrate. In these studies, carbohydrate energy excretion was equated with the non‐nitrogenous, nonfat energy. Although these studies provided consistent results, this methodological approach cannot distinguish actual excretion of dietary carbohydrate from carbohydrate in the form of large molecular compounds derived from infant or bacterial cells (which in fact comprise 90% of the measured value). Therefore, in this study we compared the absorption of carbohydrate energy to the fractional absorption of 13C derived from [D‐l‐13C]‐lactose in 10 premature infants 30–32 weeks gestational age fed either a commercial premature infant formula containing a mixture of carbohydrates (50% lactose: 50% glucose polymer) or the same formula in which lactose was the sole carbohydrate. The two methods provided comparable estimates of carbohydrate absorption (96 and 94%, respectively), although there were significant discrepancies in two infants. These studies provide evidence of external validity for the two methods

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Section: Experimental Designmentioning

confidence: 99%

Comparison of Methods for Estimating Fecal Carbohydrate Excretion in Premature Infants

Kien,

McClead,

Kepner

et al. 1993

J. pediatr. gastroenterol. nutr.

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“…(b) Day 1, time 0: [D-l-l3C]lactose (46-119 umol/kg) (Merck and Co. , Inc./Isotopes , St. Louis, MO, U.S.A.) and carrmne red were administered coincident with the infant J Pediatr Gastroenterol Nutr , Vol. 15, No.3, 1992 being placed on a metabolic bed (16). The carmine red was used to determine whether the appearance of red marker could be used as an index of how long the stools needed to be collected to detect all excess l3C.…”

Section: Experimental Designmentioning

confidence: 99%

Efficient Assimilation of Lactose Carbon in Premature Infants

Kien,

Kepner,

Grotjohn

et al. 1992

J. pediatr. gastroenterol. nutr.

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SummaryPrevious studies have shown that there is minimal fecal excretion of carbohydrate energy in premature infants with high breath H2 concentrations, implying that the colon plays an important role in salvaging lactose energy. The present study extends this work by using a stable isotope method for serial assessment of lactose carbon excretion. Thus, in nine premature infants (30–32 weeks of gestation and 11–36 days of age), we conducted 23 longitudinal studies of breath hydrogen concentration and the cumulative fecal excretion of 13C derived from a single dose of [D‐1‐13C]lactose. The ranges of values (X ± SD) for breath hydrogen concentration and lactose absorption were respectively 4–440 ppm/5% CO2 (92 ± 100) and 82–100% tracer dose (98.4 ± 3.9). In 21 studies, lactose carbon excretion was <2% of the dose. There was a significant correlation between postnatal age and breath hydrogen concentration (R = 0.48; p = 0.02). These studies suggest that colonic fermentation activity is adequate for efficient colonic salvage of lactose even during the second week of life.

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A Metabolic Bed for Collecting Excreta in Premature Infants

Cited by 2 publications

References 0 publications

Comparison of Methods for Estimating Fecal Carbohydrate Excretion in Premature Infants

Comparison of Methods for Estimating Fecal Carbohydrate Excretion in Premature Infants

Efficient Assimilation of Lactose Carbon in Premature Infants

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