“…A joint synthesis of the amounts of blood loss and blood transfusions would, however, be more meaningful as the two outcomes are clearly correlated (higher amount of blood loss needing higher number of blood transfusions).Despite these advantages, use of multivariate meta-analysis approaches are limited by the lack of reporting of the within-study correlation in the original publications, inadequate awareness of the availability of methods among practitioners, and increasing but still limited availability of statistical softwares, to name a few [7]. Application of multivariate meta-analysis methods could benefit a broad spectrum of research fields including ecology [8][9][10], psychiatry [11][12][13], nutrition [14][15][16], health prevention [17][18][19], ethics [20][21][22], and gender difference in labor market [23][24][25][26] beyond many other fields listed in [7], as research questions involving multiple correlated outcomes are common.Following the notations for univariate meta-analysis, the formulation for multivariate meta-analysis, on the basis of multivariate random-effects model, is written asD 1; 2; : : : ; n; Y i D .Y i1 ; Y i2 ; : : : ; Y iM / > IˇD .ˇ1;ˇ2; : : : ;ˇM / > ; b i D .b i1 ; b i2 ; : : : ; b iM / > I " i D ." i1 ; " i2 ; : : : ; " iM / > ;where for the ith study,ˇdescribes the vector of population effect size, b i the vector of between-study random effect, and " i the vector of within-study sampling error.…”