A meta-analytical assessment of STK39 three well-defined polymorphisms in susceptibility to hypertension

Abstract

Serine/threonine kinase 39 gene (STK39) is one of the promising hypertension-susceptibility genes identified by a genome-wide association study in 2009, whereas subsequent validation in other ethnic groups is unsatisfactory, with inconsistent and inconclusive findings. We therefore aimed to meta-analytically assess the risk prediction of STK39 three polymorphisms, rs6749447, rs35929607 and rs3754777, for primary hypertension. Literature search and data collection were independently completed by two authors. Nine articles were pooled in this study. Overall analyses failed to see any significant associations of rs6749447, rs35929607 and rs3754777 with hypertension risk (odds ratio: 1.27, 0.95 and 1.21; P = 0.270, 0.507 and 0.153, respectively), and there was evident heterogeneity for three comparisons (I2 > 80%). Meta-regression analyses indicated that smoking was a significant risk factor for the association of rs3754777 with hypertension (P = 0.017). As reflected by the Begg’s and Filled funnel plots, as well as Egger’s tests, there were low probabilities of publication bias. In conclusion, our meta-analytical findings suggest that STK39 might not be a hypertension-susceptibility gene.

Association of with‐no‐lysine kinase 1 and Serine/Threonine kinase 39 gene polymorphisms and haplotypes with essential hypertension in Tibetans

“…No significant connections between other sites and EH were found in our study, which is in accordance with some previous reports while inconsistent with others [Newhouse et al, ; Persu et al, ; Yang et al, ]. These inconsistent results may be due to the fact that most studies have focused on the single‐locus effect and disregarded epistasis, so haplotypes and WNK1‐STK39 interaction were performed in this study to overcome this drawback.…”

ATP2B1 rs2681472 and STK39 rs35929607 polymorphisms and risk of Hypertension in Iranian Population

“…Our study is in agreement with the latter studies and supports a lack of association in Iranian population. Along with the studies with conflicting results in Chinese population ( 11 , 23 ), two meta-analyses about STK39 and risk of hypertension are also demonstrative of inconclusive findings ( 13 , 26 ).…”

“…The possible link between STK39 and hypertension was first reported in a genome wide association (GWA) study in 2009 ( 12 ). After that, replication studies were performed in different ethnic groups, but the results are not consistent ( 13 ).…”

The relationship of genetic risk factors with the development of arterial hypertension taking into account ethnic differences

“…Полагаем, что противоречивость наших данных по бурятской популяции связана с особенностями онтогене тической детерминации АГ, т. к. представленные ре-зультаты полиморфизма гена CAT у Ершовой О. А. основываются на исследованиях только подростковых групп, а не взрослой популяции. В одном из крупных метаанализах оценивалась ассоциация полиморфных локусов rs6749447 и rs3754777 гена STK39 с прогнозом риска развития первичной артериальной гипертонии [11]. По его результатам ни один из этих SNP не способствовал значительному риску гипертонии.…”