A Meta-analysis of Transient Elastography for the Detection of Hepatic Fibrosis

Stebbing, Justin; Farouk, Lavanta; Panos, George; Anderson, Mike; Jiao, Long R.; Mandalia, Sundhiya; Bower, Mark; Gazzard, Brian; Nelson, Mark

doi:10.1097/mcg.0b013e3181b4af1f

Cited by 186 publications

(156 citation statements)

References 32 publications

Supporting

Mentioning

151

Contrasting

Unclassified

Order By: Relevance

“…The method has been evaluated extensively in patients with chronic hepatitis C infection [15][16][17][18][19]. It was recently demonstrated, that the degree of liver stiffness measured by TE in CP patients with concomitant cholestasis was correlated with the histologically indicated stage of liver fibrosis [6].…”

Section: Discussionmentioning

confidence: 99%

“…Noninvasive markers are increasingly used for the assessment of liver fibrosis, such as serum biomarkers and transient elastography (TE). TE was originally developed to measure the stage of liver fibrosis by assessing the stiffness of the liver in a noninvasive manner through the use of ultrasonography in cases of chronic hepatitis C infection [15][16][17][18][19]. TE has been demonstrated to be a suitable method to reveal the severity of liver fibrosis in CP and concomitant cholestasis through measurement of the liver stiffness [6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pancreatic Diabetes Mellitus and Heavy Drinking are Risk Factors for the Development of Liver Fibrosis in Alcoholic Chronic Pancreatitis

Zsóri¹,

Czepán²,

Illés³

et al. 2017

Pancreat Disord Ther

View full text Add to dashboard Cite

Objective: The coincidence of chronic pancreatitis and liver cirrhosis in alcoholic patients is comparatively rare. Our aim was to assess liver fibrosis in patients with alcoholic chronic pancreatitis (ACP) by measuring noninvasive fibrosis scores and liver stiffness. Methods:Fifty-five patients with ACP were enrolled in the study. Eight healthy volunteers served as controls. Noninvasive fibrosis scoring systems, including the aspartate aminotransferase to platelet ratio index (APRI) and fibrosis-4 score (FIB-4), were determined and transient elastography (TE) was performed.Results: Mild (F1 or F2) and severe (F3 or F4) fibrosis was revealed by TE in 15 and 6 patients (38.2%), respectively. However, the levels of the liver enzymes were elevated in only 12 patients. The APRI and FIB-4 scores jointly revealed fibrosis of the liver in two patient. ACP patients with liver fibrosis drank significantly more amount of alcohol and had diabetes more frequently than ACP patients without liver fibrosis. Conclusion:Liver fibrosis was revealed by TE in one-fourth of the ACP patients. Liver enzymes are not reliable parameters with which to diagnose liver fibrosis. The quantity of consumed alcohol and the presence of DM are risk factors for the development of liver fibrosis in ACP.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pancreatic Diabetes Mellitus and Heavy Drinking are Risk Factors for the Development of Liver Fibrosis in Alcoholic Chronic Pancreatitis

Zsóri¹,

Czepán²,

Illés³

et al. 2017

Pancreat Disord Ther

View full text Add to dashboard Cite

show abstract

“…Transient ultrasound elastography and acoustic radiation force impulse have been useful but they require specialized equipment that is not readily available in the USA [9]. In addition, these techniques cannot be used for obese patients, which represent a very significant proportion of the population requiring evaluation for liver disease.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Detection of Cirrhosis: Towards the Development of Computer-Assisted Detection Method

et al. 2014

View full text Add to dashboard Cite

There are distinct morphologic features of cirrhosis on CT examinations; however, such impressions may be subtle or subjective. The purpose of this study is to build a computer-aided diagnosis (CAD) method to help radiologists with this diagnosis. One hundred sixty-seven abdominal CT examinations were randomly divided into training (n=88) and validation (n=79) sets. Livers were analyzed for morphological markers of cirrhosis and logistic regression models were created. Using the area under curve (AUC) for model performance, the best model had 0.89 for the training set and 0.85 for the validation set. For radiology reports, sensitivity of reporting cirrhosis was 0.45 and specificity 0.99. Using the predictive model adjunctively, radiologists' sensitivity increased to 0.63 and specificity slightly decreased to 0.97. This study demonstrates that quantifying morphological features in livers may be utilized for diagnosing cirrhosis and for developing a CAD method for it.

show abstract

“…It is a relatively simple, reproducible bedside test. Stebbing et al performed a meta-analysis and showed that a liver stiffness of 7.71 kPa for fibrosis (F2 or greater) had a sensitivity of 71.9% and specificity of 82.4% whereas for cirrhosis (F4) the results showed a cutoff of 15.08 kPa with a sensitivity of 84.45% and specificity of 94.69% [23]. Limitations include obesity and active inflammation, which can give falsely high results.…”

Section: Diagnosis Of Iron Overload and Tissue Injurymentioning

confidence: 99%

Non-Hfe Iron Overload: Is Phlebotomy the Answer?

2012

View full text Add to dashboard Cite

Financial support:JKO is the recipient of a NHMRC Practitioner Fellowship (513761). DT is the recipient of a NHMRC Senior Research Fellowship (1020437). AbstractIron is an essential factor for life, however a physiologically optimal balance is critical. In this article we explore the role of iron as a co-factor in a range of chronic liver diseases and how it may contribute to the development of liver injury, fibrosis, cirrhosis and ultimately hepatocellular carcinoma. Whilst iron depletion therapy through phlebotomy is the most effective method of reducing iron stores, it is unclear whether this offers utility in the therapy of liver diseases in which iron is not the primary insult resulting in tissue injury. Here we examine the emerging evidence in the field of non-HFE hereditary haemochromatosis conditions associated with iron overload -is phlebotomy the answer?

show abstract

A Meta-analysis of Transient Elastography for the Detection of Hepatic Fibrosis

Abstract: Further evaluation of transient elastography to assess LSM is required in prospective studies to potentially increase the sensitivity and establish its clinical utility.

Cited by 186 publications

References 32 publications

Pancreatic Diabetes Mellitus and Heavy Drinking are Risk Factors for the Development of Liver Fibrosis in Alcoholic Chronic Pancreatitis

Pancreatic Diabetes Mellitus and Heavy Drinking are Risk Factors for the Development of Liver Fibrosis in Alcoholic Chronic Pancreatitis

Quantitative Detection of Cirrhosis: Towards the Development of Computer-Assisted Detection Method

Non-Hfe Iron Overload: Is Phlebotomy the Answer?

Contact Info

Product

Resources

About