A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and steroid-sensitive nephrotic syndrome in children

Zhou, Tian-Biao; Qin, Yue; Ou, Chao; Su, Li-Na; Lei, Feng-Ying; Huang, Wei-Fang; Zhao, Yanyan; Pang, Yusheng

doi:10.1177/1470320311422579

Cited by 18 publications

(7 citation statements)

References 30 publications

(48 reference statements)

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“…D allele and DD genotype have been reported to be associated with the higher plasma ACE level 36,37 . The increased protein expression of ACE is responsible for the elevation of plasma angiotensin II level 38,39 . Angiotensin II promotes podocyte injury and loss of podocytes is a hallmark of progressive kidney diseases including DN 40 .…”

Section: Discussionmentioning

confidence: 99%

Meta‐analysis of the relationship between ACE I/D gene polymorphism and end‐stage renal disease in patients with diabetic nephropathy

Chen²,

Zhang³

et al. 2012

Nephrology

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Section: Discussionmentioning

confidence: 99%

Meta‐analysis of the relationship between ACE I/D gene polymorphism and end‐stage renal disease in patients with diabetic nephropathy

Chen²,

Zhang³

et al. 2012

Nephrology

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“…10,11 Results were expressed with odds ratio (OR) for dichotomous data, and 95% confidence interval (CI) were also calculated. 12,13 For the pooled OR to be statistically significant, p<0.05 was required. I 2 was used to test the heterogeneity among the included studies.…”

Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis of the association between angiotensin II type 1 receptor A1166C gene polymorphism and myocardial infarction susceptibility

Zheng

Shi

et al. 2012

J Renin Angiotensin Aldosterone Syst

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Background and aim: Many reported studies have been conducted to investigate the association of angiotensin II type 1 receptor (AT1R) A1166C gene polymorphism with myocardial infarction (MI) susceptibility. However, the results from those reports are still conflicting. This meta-analysis was performed to study the relationship between AT1R A1166C gene polymorphism and MI risk. Method: The databases of PubMed, Embase, and Cochrane Library were searched as of 1 March 2012, and eligible investigations were recruited into this meta-analysis. Results: Eighteen investigations were identified for the analysis of association between AT1R A1166C gene polymorphism and MI risk, 11 in Caucasians, three in Asians, two in Africans, one in the population of Brazil and one in the population of Durban, South Africa . There was a marked association between AT1R C allele and MI susceptibility for overall populations (odds ratio (OR)=1.12, 95% confidence interval (CI): 1.01-1.25, p=0.03), and AT1R AA genotype was associated with a lower risk of MI in overall populations (OR=0.87, 95% CI: 0.78-0.98, p=0.02). However, AT1R A1166C gene polymorphism was not associated with MI risk in the sub-groups of Caucasians, Asians, Africans, Brazil and Durban populations. Conclusions: C allele is a risk factor for the MI susceptibility in overall populations, and AA genotype might be a protective factor against the MI risk in overall populations. However, more case-control association investigations on larger, stratified populations are required in the future.

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“…Patients with HLA-B35 may be genetically more susceptible to recurrent episodes of IgAVN, precipitated by a heterogeneous group of infective stimuli resulting in a protracted illness with significant renal involvement. Reportedly, the ACE DD genotype or D allele is associated with IgAVN susceptibility in Asians 22) .…”

Section: ) Other Biomarkersmentioning

confidence: 99%

Management of IgA vasculitis nephritis (Henoch-Schonlein purpura nephritis) in Children

Namgoong

2020

Child Kidney Dis

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Management of IgA vasculitis nephritis (Henoch-Schonlein purpura nephritis) in ChildrenImmunoglobulin (Ig)A vasculitis nephritis (IgAVN), also referred to as Henoch-Schönlein purpura nephritis, is a relatively benign disease in children. However, two 24-year European cohort studies have reported high sustained rates of hypertension, severe proteinuria, and renal dysfunction in patients with IgAVN. Notably, the incidence and exacerbation rates of proteinuria, hypertension, and renal dysfunction during pregnancy were high even in women who recovered from IgAVN before pregnancy. Patients with IgAVN need lifelong care. Trials have been performed to investigate early biomarkers and genes associated with poor prog nosis to identify high-risk patients in whom IgAVN may progress to severe renal disease. Urinary IgA/cr, IgM/cr levels, and HLAB35 and angiotensinogen gene expression were shown to be predictors of progression of IgAVN to severe renal dysfunction. The 2019 Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) initiative group published guidelines for pediatric IgAVN, following the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines established in 2012. Compared with the KDIGO guidelines, the SHARE guidelines recommend earlier corticosteroid administration in cases of mild proteinuria (>0.5 g/d). Clinical trials of targeted budesonide delivery to the distal ileum, monoclonal antibody targeting C5, eculizumab and anti-CD20 monoclonal antibody administration, among others are currently underway in patients with IgA nephropathy. It is expected that newer therapeutic agents would become available for IgAVN in the near future. This review summarizes IgAVN with emphasis on recently published literature, including possible preventive strategies, predictive biomarkers for progression of IgAVN, and various treatments.

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A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and steroid-sensitive nephrotic syndrome in children

Abstract: Conclusions: There was no association between ACE I/D gene polymorphism and SSNS susceptibility in Asians, Caucasians and Africans. However, the conclusions for Caucasians and Africans were less powerful.

Cited by 18 publications

References 30 publications

Meta‐analysis of the relationship between ACE I/D gene polymorphism and end‐stage renal disease in patients with diabetic nephropathy

Meta‐analysis of the relationship between ACE I/D gene polymorphism and end‐stage renal disease in patients with diabetic nephropathy

A systematic review and meta-analysis of the association between angiotensin II type 1 receptor A1166C gene polymorphism and myocardial infarction susceptibility

Management of IgA vasculitis nephritis (Henoch-Schonlein purpura nephritis) in Children

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