A systematic review and meta-analysis of the association between angiotensin II type 1 receptor A1166C gene polymorphism and myocardial infarction susceptibility

Abstract

Background and aim: Many reported studies have been conducted to investigate the association of angiotensin II type 1 receptor (AT1R) A1166C gene polymorphism with myocardial infarction (MI) susceptibility. However, the results from those reports are still conflicting. This meta-analysis was performed to study the relationship between AT1R A1166C gene polymorphism and MI risk. Method: The databases of PubMed, Embase, and Cochrane Library were searched as of 1 March 2012, and eligible investigations were recruited into this meta-analysis. Results: Eighteen investigations were identified for the analysis of association between AT1R A1166C gene polymorphism and MI risk, 11 in Caucasians, three in Asians, two in Africans, one in the population of Brazil and one in the population of Durban, South Africa . There was a marked association between AT1R C allele and MI susceptibility for overall populations (odds ratio (OR)=1.12, 95% confidence interval (CI): 1.01-1.25, p=0.03), and AT1R AA genotype was associated with a lower risk of MI in overall populations (OR=0.87, 95% CI: 0.78-0.98, p=0.02). However, AT1R A1166C gene polymorphism was not associated with MI risk in the sub-groups of Caucasians, Asians, Africans, Brazil and Durban populations. Conclusions: C allele is a risk factor for the MI susceptibility in overall populations, and AA genotype might be a protective factor against the MI risk in overall populations. However, more case-control association investigations on larger, stratified populations are required in the future.

Associations Between Polymorphisms of Endothelial Nitric Oxide Synthase, Matrix Metalloproteinase 3, Angiotensinogen, and Angiotensin II Type 1 Receptor and Risk of Restenosis After Percutaneous Coronary Intervention: A Meta-analysis

“…However, robustness analysis revealed the overestimation for this distortion by external factors because we discovered that 1 included publication did not meet the HWE, which resulted from sampling error and led to low representativeness of the general population. Nevertheless, previous reports suggest that the C allele is a risk factor for myocardial infarction susceptibility 44 and hypertension. 45 Activated by angiotensin II, AT1R coupled to G q/11 and activated phospholipase C, subsequently increasing the cytosolic calcium (II) concentration and triggering cellular responses, including vasoconstriction, aldosterone synthesis, and secretion, and increasing vasopressin secretion.…”

Галектин-3 Як Маркер Функції Міокарду У Чоловіків 40-60 Років Без Серцево-Судинної Патології, Носіїв Поліморфних Генів Ат1р*

“…Є дані, що для японської популяції існує асоціація між носійством СС-генотипу та підвищеним індексом маси міокарда ЛШ як при нормальному АТ, так і у гіпертензивних осіб [24]. Кореляція носійства генотипу СС з розвитком АГ знайдена і у китайській популяції [19]. В Україні також проводились дослідження серед мешканців Полтави хворих на гіпертонічну хворобу частота виявлення генотипів АС та СС вдвічі більша, а питома вага носіїв генотипу АА у 4 рази менша (р≤0,05) у порівнянні зі здоровими особами.…”

In silico prediction of ARB resistance: A first step in creating personalized ARB therapy

“…Additionally, due to the prominent role the AT 1 R plays in cardiovascular disease, the AT 1 R is also the focus of many genetic association studies. (3,4) However, very few studies have been directed toward pharmacogenomics of the AT 1 R.…”