A Meta-analysis of the Association of Exhaled Carbon Monoxide on Asthma and Allergic Rhinitis

Yu, Shengqiang; Zhang, Ruxin; Chen, Yingjian; Chen, Jianqiu; Wang, Yanshen; Li, Genhong

doi:10.1007/s12016-009-8195-1

Cited by 16 publications

(18 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can be suggested that the increase in eCO levels in patients with AR may be produced from both the lower and upper airways [29,36]. Shaoging et al [37] did not find significant differences in eCO levels between AR and the control group.…”

Section: Discussionmentioning

confidence: 94%

Factors influencing the levels of exhaled carbon monoxide in asthmatic children

Jeseňák¹,

Bánovčin²,

Havlíčeková³

et al. 2014

Journal of Asthma

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 94%

Factors influencing the levels of exhaled carbon monoxide in asthmatic children

Jeseňák¹,

Bánovčin²,

Havlíčeková³

et al. 2014

Journal of Asthma

View full text Add to dashboard Cite

show abstract

“… 232 While exhaled CO has been implicated as a likely gasotransmitter in the development of asthma, its role in the development of AR is less clear, despite being generated in the nasal mucosa of AR. 233 Similarly, the role of H2S in the pathogenesis of AR is also unclear. A previous study in humans has suggested that this gasotransmitter may have multiple functions in human nasal mucosa and contribute to the development of allergic symptoms such as rhinorrhea, sneezing and nasal stuffiness.…”

Section: Mechanismsmentioning

confidence: 99%

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Cheng

Chen

et al. 2018

Allergy Asthma Immunol Res

250

198

View full text Add to dashboard Cite

Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has increased progressively over the last few decades in more developed countries and currently affects up to 40% of the population worldwide. Likewise, a rising trend of AR has also been observed over the last 2–3 decades in developing countries including China, with the prevalence of AR varying widely in these countries. A survey of self-reported AR over a 6-year period in the general Chinese adult population reported that the standardized prevalence of adult AR increased from 11.1% in 2005 to 17.6% in 2011. An increasing number of original articles and imporclinical trials on the epidemiology, pathophysiologic mechanisms, diagnosis, management and comorbidities of AR in Chinese subjects have been published in international peer-reviewed journals over the past 2 decades, and substantially added to our understanding of this disease as a global problem. Although guidelines for the diagnosis and treatment of AR in Chinese subjects have also been published, they have not been translated into English and therefore not generally accessible for reference to non-Chinese speaking international medical communities. Moreover, methods for the diagnosis and treatment of AR in China have not been standardized entirely and some patients are still treated according to regional preferences. Thus, the present guidelines have been developed by the Chinese Society of Allergy to be accessible to both national and international medical communities involved in the management of AR patients. These guidelines have been prepared in line with existing international guidelines to provide evidence-based recommendations for the diagnosis and management of AR in China.

show abstract

“…Therefore, eCO also has clinical properties similar to FeNO. Relevant studies have shown that eCO can reflect not only airway inflammation, but also cell oxidative stress (17).…”

Section: Discussionmentioning

confidence: 99%

Changes in fractional exhaled nitric oxide, exhaled carbon monoxide and pulmonary function during the acute attack, treatment and remission phases of pediatric asthma

Xie

Chai

et al. 2020

Transl Pediatr

View full text Add to dashboard Cite

Background: The current study aimed to explore the value of fractional exhaled nitric oxide (FeNO), exhaled carbon monoxide (eCO), and pulmonary function in the management of asthmatic children.Methods: One hundred children diagnosed with asthma were selected as research subjects. Patients were divided into a 3-5-year-old group and a group with children 6 years and older. They were also grouped depending on whether they had asthma alone (A0 group) or whether their asthma was complicated with allergic rhinitis (A+AR group). The FeNO, eCO levels, and pulmonary function in the acute attack period were analyzed 1 month after treatment and clinical remission period.Results: Asthmatic children demonstrated greater pulmonary dysfunction and significantly higher FeNO and eCO during the acute attack phase compared to both one month after treatment and clinical remission. The remission phase was characterized by decreased levels of FeNO and eCO and improvement of pulmonary function. The eCO levels in children aged 3-5 years old, and both FeNO and eCO levels in children 6 years and older were statistically lower during remission regardless of whether the patients had asthma alone or asthma complicated with rhinitis. However, 10% of the 100 children in the clinical remission period still demonstrated mid to high levels of FeNO. The critical value of FeNO levels during the acute period in children 6 years and older with asthma and rhinitis was 34.5 ppb (AUROC 0.814, 95% CI: 0.684-0.944) with a sensitivity of 69.2% and specificity of 93.7%. Conclusions: Dynamic monitoring of FeNO and eCO is an effective indicator of airway inflammation and thus represents an important clinical tool in assessing the severity of asthma in children.

show abstract

A Meta-analysis of the Association of Exhaled Carbon Monoxide on Asthma and Allergic Rhinitis

Cited by 16 publications

References 30 publications

Factors influencing the levels of exhaled carbon monoxide in asthmatic children

Factors influencing the levels of exhaled carbon monoxide in asthmatic children

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Changes in fractional exhaled nitric oxide, exhaled carbon monoxide and pulmonary function during the acute attack, treatment and remission phases of pediatric asthma

Contact Info

Product

Resources

About