Factors influencing the levels of exhaled carbon monoxide in asthmatic children

Jeseňák, Miloš; Bánovčin, Peter; Havlíčeková, Zuzana; Dobrota, Dušan; Babušíková, Eva

doi:10.3109/02770903.2014.936448

Cited by 13 publications

(19 citation statements)

References 37 publications

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“…We found a significant negative correlation between the concentration of free thiol groups and eCO in atopic asthmatics and during acute exacerbation of asthma. Since we were not able to find such correlation in non-atopic asthmatics, in controlled asthma and in healthy subjects, it can be assumed that eCO could be used as an indirect marker of oxidative stress in different respiratory tract diseases, such as BA (35). …”

Section: Discussionmentioning

confidence: 60%

Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

2017

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Bronchial asthma is one of the most common chronic inflammatory diseases of the airways. In the pathogenesis of this disease, the interplay among the genes, intrinsic, and extrinsic factors are crucial. Various combinations of the involved factors determine and modify the final clinical phenotype/endotype of asthma. Oxidative stress results from an imbalance between the production of reactive oxygen species and reactive nitrogen species and the capacity of antioxidant defense mechanisms. It was shown that oxidative damage of biomolecules is strongly involved in the asthmatic inflammation. It is evident that asthma is accompanied by oxidative stress in the airways and in the systemic circulation. The oxidative stress is more pronounced during the acute exacerbation or allergen challenge. On the other hand, the genetic variations in the genes for anti-oxidative and pro-oxidative enzymes are variably associated with various asthmatic subtypes. Whether oxidative stress is the consequence of, or the cause for, chronic changes in asthmatic airways is still being discussed. Contribution of oxidative stress to asthma pathology remains at least partially controversial, since antioxidant interventions have proven rather unsuccessful. According to current knowledge, the relationship between oxidative stress and asthmatic inflammation is bidirectional, and genetic predisposition could modify the balance between these two positions—oxidative stress as a cause for or consequence of asthmatic inflammation.

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Section: Discussionmentioning

confidence: 60%

Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

2017

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“…In a meta-analysis that also referred to two studies conducted in Turkey (23,24), it was reported that the exhaled CO level was found to be higher in asthma patients who did not smoke than in those without asthma, and the CO level displayed a correlation with the severity of asthma (4). Jesenak et al (5) stated that the exhaled CO level could be used as a biological marker for allergic inflammation and oxidative stress in asthmatic children (5). However, there are two studies that show the opposite, in which no relationship was demonstrated between airflow limitations and the exhaled CO level in patients with asthma and cystic fibrosis (6,7).…”

Section: Discussionmentioning

confidence: 95%

“…In many studies, it was revealed that the end-expiratory CO (exhaled CO) level was higher in patients with severe asthma and lower in asthma patients receiving inhaled steroid therapy than in those not having therapy (2)(3)(4). Therefore, the exhaled CO level has recently begun to be used as an inflammatory biomarker in airway diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and bronchiectasis (1,5). However, it was concluded in some studies that the exhaled CO level could not be used routinely as a biomarker in patients with asthma and cystic fibrosis because no relationship was found between the exhaled CO level and airflow limitations (6,7).…”

Section: Introductionmentioning

confidence: 99%

Does the Finding of Small Airway Obstruction in Pulmonary Function Tests Effect End-Expiratory Carbonmonoxide Level?

Salepçi¹

2015

Eurasian J Pulmonol

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Objective: End-expiratory CO level, which is used to test smoking cessation is known to be effected by many factors. We aimed to evaluate effect of small airway obstruction (SAO) on end-expiratory CO levels. Methods:The study population consisted of cases who applied to smoking cessation clinic between April-December 2014. The duration of smoking (pack-years), pulmonary function tests (PFT) and end-expiratory carbonmonoxide (CO) were noted at first visit. The cases were questioned for last time of smoking and amount of cigarettes they smoked within past 12 hours. Pearson correlation test was used to determine factors effecting CO levels.Results: Mean age of 167 cases -112 male (67.1%), 55 female (32.9%) was 38.7±12.7 years. Mean duration of smoking was 23.3±16.4 pack-years, mean CO level was 14.1±6.9 ppm, mean FEF25-75% was 77.2±28.2. Mean period elapsed after last cigarette was 1.5±1.8 hours, mean number of cigarettes smoked within past 12 hours was 7.2±5.0. SAO was found in 50 cases (34.1%). Correlation analyses revealed that CO levels were correlated positively to duration of smoking and amount of cigarettes they smoked within past 12 hours (p=0.03, r=0.228; p=0.000, r=0.511, respectively) and negatively to the last time of smoking (p=0.023, r=0.176). SAO and in PFT was not correlated to CO level (p>0.05). Conclusion:End-expiratory CO level is closely related to duration of smoking, number of cigarettes smoked within past 12 hours and period elapsed after last cigarette. Presence of SAO does not seem to effect CO levels.

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“…For ultra-fine nanoparticles, there are two possible mechanisms as a function of the grain size (d p ) [44,46,48]. If the grain size is larger than twice the Debye length, a conduction channel with bulk mobility exists within a diameter (L C =d p À2δ) from the grain centre ( Figure 4C) [46,49,50]. A change in the scattering centre concentration (O 2 ,O ,O 2 ) will then only result in a change in the conduction channel width (L C ).…”

Section: Chemiresistive Sensorsmentioning

confidence: 99%

Advances in Wearable Sensing Technologies and Their Impact for Personalized and Preventive Medicine

Nasiri

Tricoli

2018

Wearable Technologies

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Recent advances in miniaturized electronics, as well as mobile access to computational power, are fostering a rapid growth of wearable technologies. In particular, the application of such wearable technologies to health care enables to access more information from the patient than standard episodically testing conducted in health provider centres. Clinical, behavioural and self-monitored data collected by wearable devices provide a means for improving the early-stage detection and management of diseases as well as reducing the overall costs over more invasive standard diagnostics approaches. In this chapter, we will discuss some of the ongoing key innovations in materials science and micro/nanofabrication technologies that are setting the basis for future personalized and preventive medicine devices and approaches. The design of wire-and powerless ultra-thin sensors fabricated on wearable biocompatible materials that can be placed in direct contact with the body tissues such as the skin will be reviewed, focusing on emerging solutions and bottlenecks. The application of nanotechnology for the fabrication of sophisticated miniaturized sensors will be presented. Exemplary sensor designs for the non-invasive measurement of ultra-low concentrations of important biomarkers will be discussed as case studies for the application of these emerging technologies.

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Factors influencing the levels of exhaled carbon monoxide in asthmatic children

Cited by 13 publications

References 37 publications

Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

Does the Finding of Small Airway Obstruction in Pulmonary Function Tests Effect End-Expiratory Carbonmonoxide Level?

Advances in Wearable Sensing Technologies and Their Impact for Personalized and Preventive Medicine

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