A meta‐analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children

Abstract

These results suggest that the MTHFR C677T, but not A1298C, polymorphism is a potential biomarker for childhood ALL risk.

The MTHFR C677T Polymorphism and Risk of Acute Lymphoblastic Leukemia: an Updated Meta-analysis Based on 37 Case-control Studies

“…Some studies reported significantly decreased prevalence of MTHFR C677T among cases in distinct ethnicity (Wang et al, 2012;Yan et al, 2012). In contrast, other studies reported an insignificant association between the MTHFR C677T and ALL (Li et al, 2011;Wang et al, 2010).…”

The MTHFR C677T Polymorphism and Prostate Cancer Risk: New Findings from a Meta-analysis of 7306 Cases and 8062 Controls

“…Such change would disturb the homeostasis of folate metabolism, which was believed to be associated with the occurrence and development of several chronic diseases. Systematic reviews and meta-analysis revealed the MTHFR SNP C677T could increase the risk of developing schizophrenia, congenital heart defects, esophageal cancer, gastric cancer and breast cancer (Lewis et al, 2005;Langevin et al, 2009;Dong et al, 2010;Zhang et al, 2010;Yin et al, 2012) while probably playing as a preventive factor against colorectal cancer and children acute lymphoblastic leukemia (Hubner et al, 2007;Taioli et al, 2009;Yan et al, 2012). There were also many studies concerning the association between prostate cancer risk and SNP C677T, however, no conclusiveness was achieved: Heijmans (Heijmans et al, 2003) suggested MTHFR SNP C677T be a risk factor of prostate cancer in Dutch population, but HSI-CHIN WU found the polymorphism conferred a significant decreased risk of the disease; moreover, some studies showed no statistical relationship between them (Stevens et al, 2008).…”

Folate Pathway Gene Polymorphisms, Maternal Folic Acid Use, and Risk of Childhood Acute Lymphoblastic Leukemia

“…Since 2001, more than 20 studies have reported on the association between the child's MTHFR genotype and risk of childhood ALL, and seven meta-analyses have been published (9)(10)(11)(12)(13)(14)(15). The results of these studies vary considerably, but the most recent studies report either no association with either polymorphism (13) or a protective effect of MTHFR 677C>T alone (14).…”