A Meta-analysis-Based Assessment of Intense Pulsed Light for Treatment of Melasma

Yi, Jinyao; Hong, Tao; Zeng, Hanling; Li, Peiwen; Li, Pinglu; Wang, Shaohua; Chen, Jia; Li, Ping; Zhou, Jianda

doi:10.1007/s00266-020-01637-x

Cited by 23 publications

(22 citation statements)

References 27 publications

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“…However, its high cost, pain during treatment, and potential for complications are major disadvantages. Skin pigmentation is best treated with erbium laser [7], but IPL is considered to be an efficient alternative [8] with a shorter downtime [9]. Skin wrinkling [4] can be improved with the injection of hyaluronic acid-based fillers [10], peels [11], or ablative lasers [12], and skin laxity [13] can be improved by radiofrequency, ultrasound, or surgery.…”

Section: Discussionmentioning

confidence: 99%

Thermo‐Mechanical Fractional Injury Therapy for Facial Skin Rejuvenation in Skin Types II to V: A Retrospective Double‐Center Chart Review

Daniely

Judodihardjo²,

Rajpar³

et al. 2021

Lasers Surg Med

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Background and Objectives: Thermo-mechanical fractional injury (TMFI) therapy (Tixel®; Novoxel®, Netanya, Israel) is an innovative technology. Along with its drug delivery enhancement features, it is widely used for facial skin rejuvenation. Our study explores the beneficial effect of the Tixel® on the different features of facial skin rejuvenation along with patients′ satisfaction rate, aiming to suggest practical recommendations for an optimal aesthetic result. Study Design/Materials and Methods: A retrospective chart review of 24 patients (20 women, 4 men, average age 56 years old) with skin types II-V who received 2 or 3 Tixel® treatments, 3-5 weeks apart in two medical centers (12 from Israel, 12 from the United Kingdom). Four experienced dermatologists compared standardized clinical photographs taken before each treatment and 3 months after the final treatment based on seven parameters that were set by 10 physicians and rated the difference on a scale of −1 to 4. Furthermore, epidemiology, treatment data, satisfaction, and safety were reviewed. Results: Out of the seven parameters that were compared (blood vessels and erythema, skin complexion, periorbital wrinkles, pigmentation and toning, pore size, vitality, wrinkles, and laxity), all features demonstrated an overall improvement, with the greatest improvement demonstrated in skin complexion (2.1± 0.49) and periorbital wrinkling (2.09 ± 0.65) followed by vitality (1.7 ± 0.49). Side effects were transient, including erythema and hyperpigmentation, and the average downtime was 1.7 days. Conclusion: TMFI is a safe and effective method for improving facial skin quality. Addressing patient′s expectations while maximizing the benefits of this novel technology will provide superior aesthetical results.

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Section: Discussionmentioning

confidence: 99%

Thermo‐Mechanical Fractional Injury Therapy for Facial Skin Rejuvenation in Skin Types II to V: A Retrospective Double‐Center Chart Review

Daniely

Judodihardjo²,

Rajpar³

et al. 2021

Lasers Surg Med

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“…IPL treatment has been utilized for years in dermatological clinical practice 23,24 . Recently, this procedure was also applied in ophthalmology to treat MGD 25,26,27 .…”

Section: Discussionmentioning

confidence: 99%

Alternation of Lipidomic in the Meibomian Gland After Exposure to Intense Pulsed Light in Patients With Meibomian Gland Dysfunction and Suggestions for Applications of 3PM Medicine

Zhao¹,

Ou²,

Tang³

et al. 2021

Preprint

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Importance: Aside from the clinical index, there is no established criterion for assessing the effectiveness of intense pulsed light (IPL) in treating meibomian gland disease.Objective：To determine if there is an association between changes in the meibum lipidomic profiles and alleviation of clinical signs in patients with meibomian gland dysfunction (MGD) who are treated with IPL. To provide predictive, preventive and and personalized medical programs for MGD patients. Design: This is an observational Study. Patients were followed for up for 6 months from January 1, 2019.Setting: This is a single center, human-oriented clinical and basic research study.Participants: Adult patients, who were diagnosed with MGD and had not received any alternative treatments for at least 3 months, were enrolled in the study. Exposures: Each patient received a series of three treatments at 3-week intervals. The meibum was collected before the first treatment (T0) and the third treatment (T2). All enrolled patients completed the whole examination and treatment. The meibum of randomly assigned 26 patients and 10 healthy volunteers was chosen for performing the lipid analysis using LC-MS/MS. Main Measures: The following information from each patient was recorded: tear break-up time (BUT), average tear BUT, tear meniscus height, assessment of the lid margin, bulbar redness, meibomian gland opening position, corneal fluorescein staining, meibomian gland drop, meibomian gland expressibility, and meibum quality.Results: A total of 191 patients’ right eyes were enrolled in the study, including 95 females (49.7%) and 96 males (50.3%), with a median age of 53 years (range: 28–85 years). IPL increased the BUT (P<0.0001, t=7.9, df=380), average tear BUT (P<0.01, t=2.774, df=374.5), and tear meniscus height (P<0.01, t=2.642, df=367.1). At the same time, IPL improved bulbar redness (P<0.0001, t=12.95, df=380) and corneal fluorescein staining (P<0.0001, t=4.147, df=380). Furthermore, following IPL treatment, the meibomian gland expressibility (MGE) and meibum quality were significantly improved (from 1.342±0.05815 to 0.9354±0.03922, P<0.0001, t=5.798, df=380 and from 1.266±0.04969 to 0.8639±0.03318, P<0.0001, t=6.733, df=380, respectively). Lipidomic analysis of the meibum characterized the changes in lipid profiles induced by IPL. Conclusion: IPL treatment offers a novel approach to markedly improve the treatment of patients with MGD due to correction of altered lipid profiles. The changes in lipid expression profiles are potential indexes to evaluate the therapeutic effectiveness of IPL treatment or other treatments on MGD. The lipid changes that are pertinent include: LPC(18:2)+HCOO, OAHFA(18:1/34:1)-H, TG(16:0/18:2/20:5)+H, and etc.. Therefore, accurate evaluation of the changes of lipid expression profile in patients with MGD can be used as a predictive, preventive, and personalized medical method.

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“…A recent metaanalysis showed a 39% reduction of Melasma Area and Severity Index (MASI) scores with IPL-based treatment of melasma. 31 Multiple studies showed moderate efficacy for the treatment of melasma. [32][33][34][35][36][37] In one melasma split-face comparative study, 38 one half of the face was treated with pulsed dye laser (PDL) and the other half was treated with IPL.…”

Section: Melasmamentioning

confidence: 99%

“…Vascular endothelial growth factor (VEGF) may be a major angiogenic factor for altered vessels in melasma. A recent meta‐analysis showed a 39% reduction of Melasma Area and Severity Index (MASI) scores with IPL‐based treatment of melasma 31 . Multiple studies showed moderate efficacy for the treatment of melasma 32‐37 …”

Section: Common Uses Of Iplmentioning

confidence: 99%

Intense pulsed light: The early years

Almukhtar

Carr

Goldman

2020

Dermatological Reviews

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Background: Intense pulsed light (IPL) is one of the most controversial and widely used light-based technologies that had its origin in San Diego in 1992 and was approved by the US Food and Drug Administration in late 1995.Aims: The purpose of this review is to highlight the early years' experience with IPL and development of its use over time.Material and Methods: Articles from PubMed on this subject were reviewed and clinical experience of the authors were shared.Results: IPL was initially developed as an improved treatment for leg telangiectasias. Its ability to successfully treat vascular lesions while minimizing purpura, a common complication of pulsed dye lasers, as well as exfoliating superficial pigmented lesions and eliminating hair, extended the clinical utility of IPL to treat both pigmented and vascular lesions, providing the basis for its role in photorejuvenation.Discussion: IPL is an effective and safe treatment modality for a wide range of dermatologic conditions from pigmented to vascular and inflammatory disorders.

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A Meta-analysis-Based Assessment of Intense Pulsed Light for Treatment of Melasma

Cited by 23 publications

References 27 publications

Thermo‐Mechanical Fractional Injury Therapy for Facial Skin Rejuvenation in Skin Types II to V: A Retrospective Double‐Center Chart Review

Thermo‐Mechanical Fractional Injury Therapy for Facial Skin Rejuvenation in Skin Types II to V: A Retrospective Double‐Center Chart Review

Alternation of Lipidomic in the Meibomian Gland After Exposure to Intense Pulsed Light in Patients With Meibomian Gland Dysfunction and Suggestions for Applications of 3PM Medicine

Intense pulsed light: The early years

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