“…For these reasons, analysis of risk factor in smaller scale regions yields more accurate predictive models encompassing both demographic and regional characteristics. Such smaller scale studies give an insight into the differences, allowing for the identification of risk factors that are most important for specific population as in a study of Fargnoli et al 25 on Italian population, Ballester et al 26 on Spanish population, Bakos et al 27 on Brazilian population, Fears et al 28 , Williams et al 24 and Cho et al 8 on North American population, Mar et al 22 on Australian population and others. Application of the prognostic models enables efficient and rapid screening and, therefore, focuses further diagnostic measures on a small group of high-risk individuals.…”