A Mediator Free Amperometric Bienzymatic Glucose Biosensor Using Vertically Aligned Carbon Nanofibers (VACNFs)

Islam, Ashraf B.; Tulip, Fahmida S.; Islam, Syed K.; Rahman, Talha; MacArthur, Kimberly

doi:10.1109/jsen.2011.2169053

Cited by 23 publications

(7 citation statements)

References 32 publications

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“…A superior electrochemical performance of aligned carbon nanofibers has been observed possibly because of a more effective electron transfer from the electroanalyte to the current collector. 52 Thus, the excellent charge transfer properties of this highly crystalline TiO 2 −NF provide a suitable platform for improved biosensor characteristics as compared to those of other materials ( Table 1 …”

Section: Resultsmentioning

confidence: 99%

Highly Sensitive Biofunctionalized Mesoporous Electrospun TiO₂ Nanofiber Based Interface for Biosensing

Mondal

Ali²,

Agrawal³

et al. 2014

ACS Appl. Mater. Interfaces

138

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ABSTRACT:The surface modified and aligned mesoporous anatase titania nanofiber mats (TiO 2 −NF) have been fabricated by electrospinning for esterified cholesterol detection by electrochemical technique. The electrospinning and porosity of mesoporous TiO 2 −NF were controlled by use of polyvinylpyrrolidone (PVP) as a sacrificial carrier polymer in the titanium isopropoxide precursor. The mesoporous TiO 2 − NF of diameters ranging from 30 to 60 nm were obtained by calcination at 470°C and partially aligned on a rotating drum collector. The functional groups such as −COOH, −CHO etc. were introduced on TiO 2 −NF surface via oxygen plasma treatment making the surface hydrophilic. Cholesterol esterase (ChEt) and cholesterol oxidase (ChOx) were covalently immobilized on the plasma treated surface of NF (cTiO 2 −NF) via N-ethyl-N0-(3-dimethylaminopropyl carbodiimide) and N-hydroxysuccinimide (EDC-NHS) chemistry. The high mesoporosity (∼61%) of the fibrous film allowed enhanced loading of the enzyme molecules in the TiO 2 −NF mat. The ChEt-ChOx/cTiO 2 −NF-based bioelectrode was used to detect esterified cholesterol using electrochemical technique. The high aspect ratio, surface area of aligned TiO 2 −NF showed excellent voltammetric and catalytic response resulting in improved detection limit (0.49 mM). The results of response studies of this biosensor show excellent sensitivity (181.6 μA/mg dL −1 /cm 2 ) and rapid detection (20 s). This proposed strategy of biomolecule detection is thus a promising platform for the development of miniaturized device for biosensing applications.

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Section: Resultsmentioning

confidence: 99%

Highly Sensitive Biofunctionalized Mesoporous Electrospun TiO₂ Nanofiber Based Interface for Biosensing

Mondal

Ali²,

Agrawal³

et al. 2014

ACS Appl. Mater. Interfaces

138

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“…Vertically aligned carbon nanofiber forest arrays have been reported in literature as novel electrode structures for biosensing platforms [1] [2]. VACNF arrays represent an attractive electrode structure for electrochemical sensor platforms due to the presence of defect sites throughout the surface, which act as the oxidation and reduction reaction centers for electrochemical reactions.…”

Section: Introductionmentioning

confidence: 99%

A robust VACNF platform for electrochemical biosensor

et al. 2013

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Vertically aligned carbon nanofiber (VACNF) is a promising electrode structure for electrochemical biosensor platform. In this paper, we address the mechanical stability and reusability issues of VACNF arrays. We demonstrate that improvement in mechanical stability requires special attention to surface treatment. We show that a thin SU8 layer on nanofiber forest forms a flexible passive layer at the base of the array and that wet etching works best to remove the passive layer from the VACNF tips. The optimum time for wet etching was found to be 2-3 minutes. We show that SU8 treated VACNF arrays have improved signal-to-noise response compared to the untreated bare VACNF arrays.

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“…Page A bienzymatic glucose biosensor that uses vertically aligned carbon nanofibers (VACNF) has been shown to detect glucose [2][3][4] . However, manufacturing VACNF is an expensive process.…”

Section: Methodology Used To Introduce the Teachers To The Research Problemmentioning

confidence: 99%

“…The teachers have learned about the engineering design and characterization concepts of carbon nanofiber (CNF) for biosensors applications through the active participation in the engineering research labs. Glucose biosensors have been shown to have increased effectiveness when their designs incorporate nanoparticles and nanostructures 1,2 .…”

mentioning

confidence: 99%

Research Experience for K-12 STEM Teachers : Charecterization of Electrospun Carbon Nanofibers (ECNF)

Huq¹,

Ghalia²

2013 ASEE Annual Conference &Amp; Exposition Proceedings

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A Mediator Free Amperometric Bienzymatic Glucose Biosensor Using Vertically Aligned Carbon Nanofibers (VACNFs)

Cited by 23 publications

References 32 publications

Highly Sensitive Biofunctionalized Mesoporous Electrospun TiO₂ Nanofiber Based Interface for Biosensing

Highly Sensitive Biofunctionalized Mesoporous Electrospun TiO₂ Nanofiber Based Interface for Biosensing

A robust VACNF platform for electrochemical biosensor

Research Experience for K-12 STEM Teachers : Charecterization of Electrospun Carbon Nanofibers (ECNF)

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A Mediator Free Amperometric Bienzymatic Glucose Biosensor Using Vertically Aligned Carbon Nanofibers (VACNFs)

Cited by 23 publications

References 32 publications

Highly Sensitive Biofunctionalized Mesoporous Electrospun TiO2 Nanofiber Based Interface for Biosensing

Highly Sensitive Biofunctionalized Mesoporous Electrospun TiO2 Nanofiber Based Interface for Biosensing

A robust VACNF platform for electrochemical biosensor

Research Experience for K-12 STEM Teachers : Charecterization of Electrospun Carbon Nanofibers (ECNF)

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Highly Sensitive Biofunctionalized Mesoporous Electrospun TiO₂ Nanofiber Based Interface for Biosensing

Highly Sensitive Biofunctionalized Mesoporous Electrospun TiO₂ Nanofiber Based Interface for Biosensing