2021
DOI: 10.1007/s13668-021-00354-4
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A Mechanistic Link Between Selenium and Coronavirus Disease 2019 (COVID-19)

Abstract: Purpose of Review Coronavirus disease 2019 (COVID-19) is a rapidly emerging disease caused by a highly contagious virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and this disease has affected millions of people across the world and led to hundreds of thousands of deaths worldwide. Nutrition is a key factor related to this disease, and nutritional status may determine the risk and outcomes of SARS-CoV-2 infection. Selenium is one of the major trace elements required for redox function… Show more

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Cited by 67 publications
(83 citation statements)
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“…Less attention has focused on modifiable risk factors preceding COVID-19 infection. While nutrition may theoretically impact COVID-19 susceptibility [3,6,[30][31][32], few investigations have specifically tested the hypothesis a priori. Low vitamin D status is associated with COVID-19 infection, severity, and mortality [33,34].…”
Section: Discussionmentioning
confidence: 99%
“…Less attention has focused on modifiable risk factors preceding COVID-19 infection. While nutrition may theoretically impact COVID-19 susceptibility [3,6,[30][31][32], few investigations have specifically tested the hypothesis a priori. Low vitamin D status is associated with COVID-19 infection, severity, and mortality [33,34].…”
Section: Discussionmentioning
confidence: 99%
“…Viral infections in general and SARS-CoV-2 infections in particular are also characterized by elevated OS, which ultimately results in immunopathological diseases. Selenium, being a multifunctional trace element, enhances immunity, decreases OS, inhibits viral infections and provides efficient support in healing the patients suffering from COVID-19 [61]. Furthermore, SeMet may inhibit single-stranded RNA viruses, such as Coxsackie virus, hepatitis C virus (HCV) and human immunodeficiency virus (HIV), at a concentration of 50 µM, as observed in in vitro studies [62].…”
Section: Semet and Viral Infectionsmentioning
confidence: 93%
“…A variety of factors including age, physiological and nutritional status, immunity strength, and genetic and environmental factors appear to be important determinants of the susceptibility of individuals to SARS-CoV-2 infection and disease severity [142]. Se supplementation effectively mitigates moderate and severe infections caused by different viruses [28] due to the high redox properties of Se compounds and the functions of selenoproteins in the host immunity.…”
Section: Recent Case Studies Ascertaining the Link Between Se Status And Resilience To Covid-19mentioning
confidence: 99%
“…Thus far, a few recent investigations have provided strong evidence for a nexus between Se status and COVID-19 outcomes [142,143]. Most of these studies were conducted in China, as this country has populations with both the lowest and the highest Se status globally.…”
Section: Recent Case Studies Ascertaining the Link Between Se Status And Resilience To Covid-19mentioning
confidence: 99%