A Mechanism for Liver Cell Injury in Viral Hepatitis: Effects of Hepatitis B Virus on Neutrophil Function in Vitro and in Children with Chronic Active Hepatitis

Changes in Superoxide Anion Production in Neutrophils from Multitransfused β-Thalassemia Patients: Correlation with Ferritin Levels and Liver Damage

“…Transfusions are known to lead //-thal assemia patients to HBV infection [18], In previous studies we demonstrated that HBV is able to increase O2' production in resting and PMA-stimulated PMNs and NBT reduction in resting PMNs from children with chronic hepatitis [19,20], Analogous modifications, as to C>2' pro duction, have been observed in //-thalas semia patients. Even though none of the patients were HBsAg-positive, a role of HBV cannot be ruled out since more than 70% of the patients showed antibodies to surface and core antigens of HBV.…”

Mitochondrial dysfunction in rabies virus infection of neurons

“…In hepatitis B-infected transgenic mice, the level of ROS generation by activated phagocytes was increased (Hegan et al, 1994). Similarly, high levels of superoxide radicals were detected in the resting neutrophils of children with chronic hepatitis B infection, although activated neutrophils did not follow the same trend (Vierucci et al, 1983, andUehara et al, 1994). The expression of hepatitis B genome in human hepatoma hep 3B cells decreased the activity of superoxide dismutase and catalase whereas glutathione peroxidase was completely absent (Bannister et al, 1986).…”

Oxidative Stress, Redox Regulation and Elite Controllers of HIV Infection: Towards a Functional Cure

“…Currently, it is known that other viruses (DNA, RNA) could cause cell death through generation of ROS in the infected cell [20,21]. There is confirmed increased free radical production in stage 2 of HIV infection than in stage 4 [22].…”