A mathematical perspective on CD4+ T cell quorum-sensing

Reynolds, Joseph M.; Amado, Inês F.; Freitas, António A.; Lythe, Grant; Molina-Parı́s, Carmen

doi:10.1016/j.jtbi.2013.12.019

Cited by 8 publications

(6 citation statements)

References 56 publications

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“…This process, termed quorum sensing, allows individual members of a community to exhibit collectivist behaviors in order to coordinate expression of energetically expensive processes involved in virulence and differentiation (71). While quorum sensing has been theorized to be relevant to understanding lymphocyte behavior (72,73), our data add to growing experimental data demonstrating that, under certain circumstances, T cells can also exhibit collectivist behaviors (74,75).…”

Section: Discussionmentioning

confidence: 72%

Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy

Klebanoff¹,

Scott²,

Leonardi³

et al. 2015

Journal of Clinical Investigation

201

221

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Section: Discussionmentioning

confidence: 72%

Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy

Klebanoff¹,

Scott²,

Leonardi³

et al. 2015

Journal of Clinical Investigation

201

221

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“…Thus, IL-2 from strongly activated clones co-opt a fraction of weaker clones into activation and proliferation (Voisinne et al, 2015) and contribute thereby to continuous heterogeneity of the responding population. Second, IL-2 may act as a gatekeeper for T cell homeostasis during an immune response, initiating the down-modulation of excessive or boosting of weak effector T cell responses by the interplay of Th and Treg cells (Almeida et al, 2012, 2006; Amado et al, 2013; Reynolds et al, 2014). …”

Section: Discussionmentioning

confidence: 99%

Adequate immune response ensured by binary IL-2 and graded CD25 expression in a murine transfer model

Fuhrmann

Lischke

Groß

et al. 2016

eLife

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The IL-2/IL-2Ralpha (CD25) axis is of central importance for the interplay of effector and regulatory T cells. Nevertheless, the question how different antigen loads are translated into appropriate IL-2 production to ensure adequate responses against pathogens remains largely unexplored. Here we find that at single cell level, IL-2 is binary (digital) and CD25 is graded expressed whereas at population level both parameters show graded expression correlating with the antigen amount. Combining in vivo data with a mathematical model we demonstrate that only this binary IL-2 expression ensures a wide linear antigen response range for Teff and Treg cells under real spatiotemporal conditions. Furthermore, at low antigen concentrations binary IL-2 expression safeguards by its spatial distribution selective STAT5 activation only of closely adjacent Treg cells regardless of their antigen specificity. These data show that the mode of IL-2 secretion is critical to tailor the adaptive immune response to the antigen amount.DOI: http://dx.doi.org/10.7554/eLife.20616.001

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“…The quantitative composition of immune cell populations, shaped in the early phases of mammalian life, is typically preserved throughout adulthood [3], and quorum sensing appears to contribute to this composition. In addition, quorum sensing might also be essential for optimizing the repertoire (e.g., antibody-isotype and cytokine secretion) of immune-competent cells and the capacity of immune cells to respond to exogenous antigens, as well as to maintain self-tolerance [4][5][6].…”

mentioning

confidence: 99%

Rethinking Communication in the Immune System: The Quorum Sensing Concept

Antonioli

Blandizzi

Pacher

et al. 2019

Trends in Immunology

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Quorum sensing was first described as the communication process bacteria employ to coordinate changes in gene expression and therefore, their collective behavior in response to population density. Emerging new evidence suggests that quorum sensing can also contribute to the regulation of immune cell responses. Quorum sensing might be achieved by the ability of immune cells to perceive the density of their own populations or those of other cells in their environment; responses to alterations in cell density might then be coordinated via changes in gene expression and protein signaling. Quorum sensing mechanisms can regulate T and B cell as well as macrophage function. We posit that perturbations in quorum sensing may undermine the balance between diverse immune cell populations, and predisposing a host to immune abnormalities.

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A mathematical perspective on CD4+ T cell quorum-sensing

Cited by 8 publications

References 56 publications

Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy

Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy

Adequate immune response ensured by binary IL-2 and graded CD25 expression in a murine transfer model

Rethinking Communication in the Immune System: The Quorum Sensing Concept

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