A mathematical model for the corneal transparency problem

Abstract

Understanding the physical basis of corneal transparency has been a subject of interest amongst physicists, basic scientists and ophthalmologists. Impairment of corneal clarity is a significant cause of visual morbidity worldwide. Thus, it is essential to understand the mechanisms behind corneal transparency and how the alterations due to corneal pathologies affect vision. We use Maxwell’s equations to model light propagation in ocular tissues and a nodal discontinuous Galerkin method combined with an explicit Runge-Kutta method to simulate light propagation in normal and pathological corneas. Our simulation results illustrate that an increase in the diameter of some fibres causes an increase in backscattering. Thus, these may represent some of the physical changes in the cornea that might result in loss of transparency and visual morbidity.

Changes in the Biomechanical Properties of Corneal Stromal Lens after Collagen Crosslinking Induced by EDC-NHS

“…Tis improvement may result from increased collagen fbrillar alignment after crosslinking. Relative to noncrosslinked controls, light transmittance was not compromised and instead improved for all crosslinked groups, potentially attributable to enhanced collagen fber alignment regularity postcrosslinking [9], which impacts corneal transparency [10]. Te marked transmittance decline of the ribofavin crosslinking group in the near UV spectrum likely stems from residual ribofavin absorption peaks at 371 nm and 442 nm [11].…”