A Materials Perspective on the Design of Damage-Resilient Bone Implants Through Additive/Advanced Manufacturing

Ferrand, Hortense Le; Athanasiou, Christos E.

doi:10.1007/s11837-019-03999-3

Cited by 15 publications

(12 citation statements)

References 166 publications

(154 reference statements)

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“…In addition, the optimization of chemical formulations and of their processes could generate ceramics with unique structural and functional properties, such as shape-memory and ductility [7,8], transparency [9], high capacity [10], biocompatibility [11], etc. Such properties make ceramic materials applicable in a large range of applications, from sensors [12] to actuators [13], batteries [14], implants [15], protective shields [16], reflectors [17], heat exchangers [18], etc.…”

Section: | Introductionmentioning

confidence: 99%

Magnetic slip casting for dense and textured ceramics: A review of current achievements and issues

Ferrand

2021

Journal of the European Ceramic Society

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Ceramic materials are ubiquitous in technologies operating under high mechanical, thermal or chemical constrains. Research in ceramic processing aims at creating ceramics with properties that are still challenging to obtain, such as toughness, transparency, conductivity, among others. Magnetic slip casting is a ceramic process where an external magnetic field is used to align the ceramic grains along preferential crystallographic directions, thereby creating controlled texture. Over the past 20 years of research on magnetic slip casting, ceramics of multiple chemistry were found to exhibit enhanced properties as a result from the texturation. This paper reviews the progress in the field of magnetic slip casting, details the processing parameters, the textures obtained for a diverse range of ceramic materials. The achieved mechanical and functional properties of the magnetically textured parts are presented. This overview of the magnetic slip casting process allows to identify critical directions for future advancement in advanced technical ceramics.

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Section: | Introductionmentioning

confidence: 99%

Magnetic slip casting for dense and textured ceramics: A review of current achievements and issues

Ferrand

2021

Journal of the European Ceramic Society

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“…Among the various CPCs, hydroxyapatite (HA), tricalcium phosphate (TCP), and a mixture of both, biphasic calcium phosphate (BCP), have been the most studied and the most promising candidates for bone repair [4]. Indeed, these CPCs fulfill most of the most important criteria required for their use as load-bearing clinical implants, which are [5]:…”

Section: | Introductionmentioning

confidence: 99%

Bioinspired approaches to toughen calcium phosphate-based ceramics for bone repair.

Dee

You

Teoh

et al. 2020

Journal of the Mechanical Behavior of Biomedical Materials

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Highlights:• Bone has a complex multi-level hierarchical organisation. This structural organisation is key for its outstanding properties. • Artificial calcium phosphate ceramics (CPCs) are promising for achieving the set of mechanical and biological requirements for use as bone implants. • At individual lengthscales, methods have been developed to control crystal phases, microscale porosity and macroscopic geometry but the CPCs produced remain intrinsically brittle. • Inspired by the organisation of bones and other biomaterials, CPCs and their composites could have their toughness increased through multi-level hierarchical microstructures. • Challenges remain but recent advances in ceramic processing and toughening may pave the way for a new generation of medical implants.

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“…Especially when scaffolds are applied in load-bearing conditions in small animal models, brittle tissue substitutes are sometimes difficult to handle and might be damaged pre- or post-implantation [ 2 , 56 ]. Scaffold residues resulting from this damage might then migrate into the surrounding tissue and induce inflammation or fibrosis that can negatively affect the tissue regeneration process [ 57 ]. Therefore, the incorporation of PCL microfibers adds a new option to the previous externally and internally applied CPC-reinforcing strategies [ 58 ], whereas the surrounding PCL frame ( Figure 6 C,F) might even be advantageous for fixing an implant to adjacent tissue.…”

Section: Discussionmentioning

confidence: 99%

3D Plotting of Calcium Phosphate Cement and Melt Electrowriting of Polycaprolactone Microfibers in One Scaffold: A Hybrid Additive Manufacturing Process

Kilian

Witzleben

Lanaro

et al. 2022

JFB

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The fabrication of patient-specific scaffolds for bone substitutes is possible through extrusion-based 3D printing of calcium phosphate cements (CPC) which allows the generation of structures with a high degree of customization and interconnected porosity. Given the brittleness of this clinically approved material, the stability of open-porous scaffolds cannot always be secured. Herein, a multi-technological approach allowed the simultaneous combination of CPC printing with melt electrowriting (MEW) of polycaprolactone (PCL) microfibers in an alternating, tunable design in one automated fabrication process. The hybrid CPC+PCL scaffolds with varying CPC strand distance (800–2000 µm) and integrated PCL fibers featured a strong CPC to PCL interface. While no adverse effect on mechanical stiffness was detected by the PCL-supported scaffold design; the microfiber integration led to an improved integrity. The pore distance between CPC strands was gradually increased to identify at which critical CPC porosity the microfibers would have a significant impact on pore bridging behavior and growth of seeded cells. At a CPC strand distance of 1600 µm, after 2 weeks of cultivation, the incorporation of PCL fibers led to pore coverage by a human mesenchymal stem cell line and an elevated proliferation level of murine pre-osteoblasts. The integrated fabrication approach allows versatile design adjustments on different levels.

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A Materials Perspective on the Design of Damage-Resilient Bone Implants Through Additive/Advanced Manufacturing

Abstract: Critical reviewA materials perspective on the design of damage-resilient artificial bones and bone implants through additive/advanced manufacturing.

Cited by 15 publications

References 166 publications

Magnetic slip casting for dense and textured ceramics: A review of current achievements and issues

Magnetic slip casting for dense and textured ceramics: A review of current achievements and issues

Bioinspired approaches to toughen calcium phosphate-based ceramics for bone repair.

3D Plotting of Calcium Phosphate Cement and Melt Electrowriting of Polycaprolactone Microfibers in One Scaffold: A Hybrid Additive Manufacturing Process

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