Bioinspired approaches to toughen calcium phosphate-based ceramics for bone repair.

Dee, Peifang; You, Ha Young; Teoh, Swee Hin; Ferrand, Hortense Le

doi:10.1016/j.jmbbm.2020.104078

Cited by 42 publications

(25 citation statements)

References 156 publications

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“…Studies revealed that, during the thermal treatment, Gr may prevent the successful coalescence of all ceramic particles, leading to an open porosity and a less-densified microstructure. However, the occurrence of a secondary porosity with bone-like pore sizes was shown as beneficial for cell adhesion and proliferation, fluid transportation, and/or nerve accommodation [ 8 ].…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the practicality of Lu fiber use as porogen template is restricted by the concomitant addition of the Gr agent (as mechanical reinforcement agent) up to maximum 0.50 wt.% when the sintering program is conducted in nitrogen ambient. Other than that, the proposed 3D geometries comply with the tortuosity and interconnectivity degree, the pore and channel sizes (around 100–500 μm) [ 5 , 8 , 71 ], and can stand as precursor arrays for future osteogenesis when implemented in various bone healing applications. Since the mechanical features are also of great importance for favorable in vivo performance of the scaffolds, a compromise can be attained with respect to the porosity degree [ 32 ], by modulating the amounts of Lu fibers and/or Gr agents.…”

Section: Resultsmentioning

confidence: 99%

“…The well-known drawbacks of the standard biological approaches (e.g., autografts and allografts) [ 4 , 8 , 9 , 10 , 11 ] have put a concerted focus on alternative solutions based on calcium phosphates (CaP)-based products (i.e., HA, β- and α-tricalcium phosphate (TCP, Ca 3 (PO 4 ) 2 ), brushite (DCPD, CaHPO 4 ·2H 2 O), calcium pyrophosphate (CPP, Ca 2 P 2 O 7 ), or the combination of them) [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. The extension of the range of biomedical applicability requires continuous improvements of this category of bioactive materials.…”

Section: Introductionmentioning

confidence: 99%

“…The concerning economic aspects circumscribed to waste disposal recently engendered strategies oriented towards reviving some of the natural materials/resources (i.e., marine shells and bones, marble, plant and animal fibers, wood chips) by sustainably recycling them into value-added parts for different industries (bio-medical included) [ 4 , 8 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. The use of vegetable fibers (sourced in considerable amounts and at low costs) was tackled, mostly for the mechanical and thermal reinforcement of composites, after being chemically processed or polymer-bonded to ceramic matrices [ 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

“…The bone-defect-shaped product should also withstand significant static (e.g., hardness, compressive strength) and dynamic (e.g., fatigue and crack propagation resistance) mechanical stresses [ 8 , 31 ]. Consequently, CaPs have long been investigated to reduce their susceptibility to implant loosening and failure (mainly owned to the intrinsic brittleness, low toughness, ductility, and wear resistance) and improve their mechanical reliability [ 5 , 9 , 25 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

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Fiber-Templated 3D Calcium-Phosphate Scaffolds for Biomedical Applications: The Role of the Thermal Treatment Ambient on Physico-Chemical Properties

et al. 2021

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A successful bone-graft-controlled healing entails the development of novel products with tunable compositional and architectural features and mechanical performances and is, thereby, able to accommodate fast bone in-growth and remodeling. To this effect, graphene nanoplatelets and Luffa-fibers were chosen as mechanical reinforcement phase and sacrificial template, respectively, and incorporated into a hydroxyapatite and brushite matrix derived by marble conversion with the help of a reproducible technology. The bio-products, framed by a one-stage-addition polymer-free fabrication route, were thoroughly physico-chemically investigated (by XRD, FTIR spectroscopy, SEM, and nano-computed tomography analysis, as well as surface energy measurements and mechanical performance assessments) after sintering in air or nitrogen ambient. The experiments exposed that the coupling of a nitrogen ambient with the graphene admixing triggers, in both compact and porous samples, important structural (i.e., decomposition of β-Ca3(PO4)2 into α-Ca3(PO4)2 and α-Ca2P2O7) and morphological modifications. Certain restrictions and benefits were outlined with respect to the spatial porosity and global mechanical features of the derived bone scaffolds. Specifically, in nitrogen ambient, the graphene amount should be set to a maximum 0.25 wt.% in the case of compact products, while for the porous ones, significantly augmented compressive strengths were revealed at all graphene amounts. The sintering ambient or the graphene addition did not interfere with the Luffa ability to generate 3D-channels-arrays at high temperatures. It can be concluded that both Luffa and graphene agents act as adjuvants under nitrogen ambient, and that their incorporation-ratio can be modulated to favorably fit certain foreseeable biomedical applications.

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Section: Resultsmentioning

confidence: 99%