A manganese superoxide dismutase (MnSOD) from Ruditapes philippinarum: Comparative structural- and expressional-analysis with copper/zinc superoxide dismutase (Cu/ZnSOD) and biochemical analysis of its antioxidant activities

Umasuthan, Navaneethaiyer; Bathige, S.D.N.K.; Revathy, Kasthuri Saranya; Lee, Jehee; Whang, Ilson; Choi, Cheol Young; Park, Hae Chul

doi:10.1016/j.fsi.2012.06.024

Cited by 67 publications

(28 citation statements)

References 48 publications

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“…It was deducted that LycSOD1 might play main functions in regulating and eliminating excessive ROS. Similar results of SOD genes in the same tissue had been reported in Ruditapes philippinarum [30]. EcCu/Zn-SOD could be transferred to the outside of the cell under the action of signal peptide, thus in contrast to intracellular icCu/Zn-SOD and Mn-SOD, the expression of ecCu/Zn-SOD restricted to only a few cell types in several tissues [31].…”

Section: Discussionsupporting

confidence: 83%

“…Compared with Mn-SOD and ecCu/Zn-SOD, the expression of icCu/Zn-SOD was more stable [1]. But this was not unique expression profile in other aquatic organisms, such as icCu/Zn-SOD in R. philippinarum, which was not the highest expression in all point of post-injection [30]. Therefore, the expression was related to the species, growth and body size.…”

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Identification and analysis of icCu/Zn-SOD, Mn-SOD and ecCu/Zn-SOD in superoxide dismutase multigene family of Pseudosciaena crocea

Liu

Chi

et al. 2015

Fish & Shellfish Immunology

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 90%

Identification and analysis of icCu/Zn-SOD, Mn-SOD and ecCu/Zn-SOD in superoxide dismutase multigene family of Pseudosciaena crocea

Liu

Chi

et al. 2015

Fish & Shellfish Immunology

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“…The tissue-distribution profile of MgeMnSOD was similar to that reported for the MnSOD in blood clam T. granosa, with the highest expression in hepatopancreas [23]. In A. irradians and C. gigas, the expression levels of MnSODs were highest in gills, while the predominant expression of MnSOD from Ruditapes philippinarum was detected in hemocytes [13,21,24]. The variable Table 2.Numbers at the forks indicate the bootstrap values (in %) out of 1000 replicates.…”

Section: Tissue-specific Expression Of Mgemnsod and Mgecuznsodsupporting

confidence: 68%

“…expression level of MnSOD was speculated to be related with tissue-dependent mitochondrial content and oxidative load [23]. For CuZnSOD, the transcript was dominantly detected in gills of Chlamys farreri and A. irradians, whereas extracellular CuZnSOD of A. irradians and intracellular CuZnSOD of R. philippinarum transcripts were mainly detected in hemocytes [14,18,19,24]. The differences in the tissue-distribution of CuZnSOD expression may be attributed to the balance of various biological processes acting on the production of ROS in different environments [18].…”

Section: Tissue-specific Expression Of Mgemnsod and Mgecuznsodmentioning

confidence: 99%

Molecular characterization of a manganese superoxide dismutase and copper/zinc superoxide dismutase from the mussel Mytilus galloprovincialis

Wang

Yuan

et al. 2013

Fish & Shellfish Immunology

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“…As the prime antioxidant enzymes, SOD, can prevent oxidative stress and preventing free radical-induced cellular damage though catalyzing the dismutation reaction of reactive oxygen species (ROS) into oxygen (O 2 ) and H 2 O 2 in biological systems [36][37][38] .…”

Section: Discussionmentioning

confidence: 99%

Erkek Ratlarda Gentamisinin İndüklediği Üreme Hasarına Karşı Karahindiba (Taraxatum officinale) Ekstresinin Koruyucu Etkisi

Ömür¹,

Kandemir²,

Yıldırım³

et al. 2016

Kafkas Univ Vet Fak Derg

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The aim of this study was to investigate the effect of Taraxacum officinale extract (TOE) on gentamicin-induced reproductive damage in male rats. Totally, 24 male Sprague Dawley rats were divided into four groups: Group I (n=6); referred as control, physiological saline was intraperitoneally (IP) administered. Group II (n=6); referred as gentamicin (G), 80 mg/kg gentamicin sulphate (GS) was injected IP. Group III (n=6); referred as G + TOE150, 80 mg/kg GS and 150 mg/kg TOE was given IP. Group IV (n=6); referred as G+TOE200 (n=6), 80 mg/kg GS and 200 mg/kg TOE was administered IP. The treatment continued for consecutive 8 days. The cauda epididymal semen samples and testes tissues were collected. Routine semen examinations were performed and oxidative stress levels of testicular tissues were assayed. Reproductive organ weights [total testes weight (TTW) and total cauda epididymal weights (TCEW)] were recorded. GS administration significantly decreased sperm motility (P<0.01), glutathione peroxidase (GPx) activity (P<0.001) and glutathione (GSH) level (P<0.05), and it significantly increased tissue malondialdehyde (MDA) level (P<0.01) in comparison with the control group. However, a statistical increase in sperm motility of GT150 (P<0.01) group and in GPx activities of both GT150 and GT200 (P<0.01) groups as well as a statistical decrease in MDA levels of GT150 and GT200 (P<0.001) groups were determined when compared with the G group. In conclusion, short-term administration of GS causes lipid peroxidative damages in testes as well as decreases in sperm motility. However, TOE has a moderate ameliorative effect on sperm motility reductions, but marked improvement effect on lipid peroxidative testicular damages induced by GS. Keywords: Taraxacum officinale, Gentamicin, Reproduction, Rat, Oxidative stress Erkek Ratlarda Gentamisinin İndüklediği Üreme Hasarına Karşı Karahindiba (Taraxatum officinale) Ekstresinin Koruyucu Etkisi ÖzetBu çalışmanın amacı, gentamisinin erkek ratlarda oluşturduğu reprodüktif hasar üzerine karahindiba ekstresinin (Taraxacum officinale extract, TOE) etkilerini araştırmaktı. Toplam 24 adet erkek Sprague Dawley rat dört gruba bölündü: Grup I (n= 6) kontrol grubu olarak adlandırıldı ve hayvanlara intraperitonal yolla fizyolojik tuzlu su uygulandı. Grup II (n=6) gentamisin (G) olarak adlandırıldı ve hayvanlara 80 mg/kg gentamisin sülfat (GS) intraperitonal (IP) yolla enjekte edildi. Grup III (n=6) G + TOE150 olarak adlandırıldı, 80 mg/kg GS ve 150 mg/kg TOE hayvanlara IP yolla enjekte edildi. Grup IV G+TOE200 (n=6) olarak adlandırıldı ve 80 mg/kg GS ile 200 mg/kg TOE hayvanlara IP yolla enjekte edildi. Tedavi ardışık 8 gün boyunca uygulandı. Kauda epididimal sperm örnekleri ve testis dokuları toplandı. Rutin sperma muayeneleri yapıldı ve testis dokularının oksidatif stres düzeyleri ölçüldü. Reprodüktif organ ağırlıkları [toplam testis ağırlığı (TTW) ve toplam kauda epididimis ağırlıkları (TCEW)] kaydedildi. GS uygulaması önemli ölçüde sperm motilitesini (P<0.01), glutatyon peroksidaz (GP...

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A manganese superoxide dismutase (MnSOD) from Ruditapes philippinarum: Comparative structural- and expressional-analysis with copper/zinc superoxide dismutase (Cu/ZnSOD) and biochemical analysis of its antioxidant activities

Cited by 67 publications

References 48 publications

Identification and analysis of icCu/Zn-SOD, Mn-SOD and ecCu/Zn-SOD in superoxide dismutase multigene family of Pseudosciaena crocea

Identification and analysis of icCu/Zn-SOD, Mn-SOD and ecCu/Zn-SOD in superoxide dismutase multigene family of Pseudosciaena crocea

Molecular characterization of a manganese superoxide dismutase and copper/zinc superoxide dismutase from the mussel Mytilus galloprovincialis

Erkek Ratlarda Gentamisinin İndüklediği Üreme Hasarına Karşı Karahindiba (Taraxatum officinale) Ekstresinin Koruyucu Etkisi

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