A mandibular eosinophilic granuloma studied with the light and electron microscopes

Csiba, A; Dzsinich, Csaba; Okrös, I; Szabó, Dénes

doi:10.1016/0030-4220(70)90343-9

Cited by 8 publications

(2 citation statements)

References 13 publications

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“…These cells had the distinctive features of welldifferentiated histiocytes, e.g., a large nutnber of lysosomes and numerous phagosomes. Similar observations were described in other lesions (Kondo et al 1969, Csiba et al 1970, Elema & Poppema 1978. The possibility that these cells were the tnature form of clear cells seemed to be negligible, since no intermediate or transitional forms were seen in the present study.…”

Section: Discussionsupporting

confidence: 92%

“…Ultrastruetural studies of all the variants of histocytosis X, eosinophilie granuloma of bone (Cancilla 1968, De Man 1968, Friedman & Hanaoka 1969, Kondo et al 1969, Csiba et al 1970, Basset et al 1972, Cutler & Krutchkoff 1977, Jaubert et al 1980), Hand-Schuller-Christian disease (Ritter 1966, Gianotti & Caputo 1969, Imamura & Muroya 1971, Basset et al 1972, Hakozaki et al 1976) and Letterer-Siwe disease (Cancilla et al 1967, Tarnowski & Hashimoto 1967, De Man 1968, Gianotti et al 1968, Hashimoto & Tarnowski 1968, Kondo et al 1969, Niebauer et al 1969, Wolff & Sollereder 1969, Shamoto 1970, Basset ct al. 1972, Breathnach et al 1973, Elema & Poppema 1978, Gonzalez-Crussi et al 1981) revealed the presence of Langerhans cell granules in the cytoplasms of the proliferating eells.…”

Section: Discussionmentioning

confidence: 99%

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An ultrastructural and immunohistochemical study on mandibular lesion of Letterer‐Siwe disease

Ide¹,

Sano²,

Shimura³

et al. 1981

J Oral Pathology Medicine

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A mandibular lesion from an infant with Letterer‐Siwe disease was studied by electron microscopy and immunohistochemistry. Ultrastructurally, two types of cells were identified; clear and dark cells. Clear cells had indented nuclei and Langerhans cell granules, while dark cells were characterized by the occasional presence of a large number of lysosomes. Lysozyme was usually not detectable in proliferating cells with indented nuclei, but it was strongly positive in cells without indented nuclei. The latter also usually contained IgG, although the occurrence of cytoplasmic IgM, A, D and E seemed to be negative in both types of cells. Thus clear cells showed a close resemblance to Langerhans cells and dark cells had features of ordinary histiocytes. Although the intimate relationship between these two types of cells remains obscure, our findings suggest that Letterer‐Siwe disease may be a reactive or tumorous condition of a cellular subpopulation of Langerhans cells with a proliferation of differentiated histiocytes.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

An ultrastructural and immunohistochemical study on mandibular lesion of Letterer‐Siwe disease

Ide¹,

Sano²,

Shimura³

et al. 1981

J Oral Pathology Medicine

View full text Add to dashboard Cite

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Eosinophilic Granuloma of Bone

Slater

Swarm

1980

Med. Pediatr. Oncol.

116

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Eosinophilic granuloma of bone is an uncommon granulomatous process for which therapy recommendations vary considerably. Consequently, a survey of the world literature from 1940 to 1974 was undertaken in an attempt to develop more concrete guidelines. This survey revealed that the disease manifests itself primarily in males under 20 years of age of all races. The most common symptom is pain, with or without swelling. Multiple sites in a single case are frequent. The clinical course is generally benign, unlike Letterer-Siwe disease or Hand-Schuller-Christian disease. A remission rate of 95% was noted, with relapses usually occurring as distant disease within the first year. Simple excision or curettage was the most common surgical procedure utilized, and radiotherapy doses varied widely. Excellent local control of the disease can be provided using conservative surgery, low-dose irradiation, or both. Morbidity secondary to pathologic fracture or to overly aggressive treatment are the major concerns, not failure to control the disease.

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