A Man with Interstitial Pneumonia Due to Propylthiouracil

Abstract

A 50-year-old Japanese manwith Grave's disease had been taking propylthiouracil (PTU) for 10 years prior to the diagnosis of pneumonia. He noticed dyspnea on exertion and had a dry cough for at least 2 years and then

Auto-imunidade ANCA (Anticorpo Anti-Citoplasma de Neutrófilos) positiva induzida por propiltiouracil: relato de caso e revisão da literatura

“…Igualmente, aqueles pacientes que desenvolvem sinais e sintomas suspeitos de vasculite devem realizar a dosagem e, conforme os títulos dos anticorpos, necessitam avaliação quanto à suspensão da medicação e encaminhamento para tratamento definitivo do hipertireoidismo (12,15).…”

Propylthiouracil-Induced Interstitial Pneumonia in a Caucasian Woman with Amiodarone-Induced Thyrotoxicosis

“…Pulmonary complications include adult respiratory distress-like syndrome, 1 Unit cavitary lung lesions, pleural effusions, and interstitial pneumonia (13)(14)(15). Until now four cases of interstitial pneumonia due to PTU have been reported, these occurred only in Asian subjects (14)(15)(16), and all had Graves' disease (Table 1). Here we report the first case in a Caucasian woman, and the first case in a patient who was given PTU for thyrotoxicosis that was not due to Graves' disease.…”

Propylthiouracil-induced Bronchiolitis Obliterans Organizing Pneumonia

“…Five cases of PTU-related interstitial pneumonia have been reported to date (2)(3)(4)(5), one of which suggested a possible bronchiolitis obliterans organizing pneumonia (BOOP)-like pattern on a transbronchial lung biopsy (5). We herein describe the first known case of PTU-induced BOOP that was pathologically confirmed on a surgical lung biopsy.…”

“…Of the five previously reported cases of interstitial pneumonia, four were treated with PTU after the patient developed an allergic reaction to methimazole (2,3,5). Therefore, the development of interstitial pneumonia was thought to be related to an antecedent allergic reaction to methimazole in a patient taking PTU.…”

“…All pulmonary function tests were normal. Laboratory tests showed a white blood cell count of 4,700/mm 3 (eosinophils, 7%), a hemoglobin concentration of 13.3 g/dL, a platelet count of 293,000/mm 3 , an erythrocyte sedimentation rate of 37 mm/h and a Creactive protein level of 0.2 mg/dL. The oxygen saturation on room air was 95%.…”