Propylthiouracil-Induced Interstitial Pneumonia in a Caucasian Woman with Amiodarone-Induced Thyrotoxicosis

Diazzi, Chiara; Brigante, Giulia; Rossi, Giulio; Rochira, Vincenzo

doi:10.1089/thy.2011.0328

Cited by 4 publications

(8 citation statements)

References 19 publications

(39 reference statements)

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“…Therefore, the mechanisms underlying the development of PTU-associated interstitial pneumonia remain unclear. However, it is notable that all reported cases of PTUinduced interstitial pneumonia, including the present case, occurred in patients who were more than 50 years old, as noted by Diazzi et al (5).…”

Section: Discussionsupporting

confidence: 65%

“…A relationship between PTU and autoimmunity, including the development of ANCA, has been suggested to explain the mechanism of PTU-related interstitial pneumonia (3). However, the present patient and two previous patients (4,5) were all negative for autoantibodies, including ANCA. Therefore, the mechanisms underlying the development of PTU-associated interstitial pneumonia remain unclear.…”

Section: Discussionsupporting

confidence: 39%

“…Five cases of PTU-related interstitial pneumonia have been reported to date (2)(3)(4)(5), one of which suggested a possible bronchiolitis obliterans organizing pneumonia (BOOP)-like pattern on a transbronchial lung biopsy (5). We herein describe the first known case of PTU-induced BOOP that was pathologically confirmed on a surgical lung biopsy.…”

Section: Introductionmentioning

confidence: 83%

“…The possibility of BOOP associated with PTU has been previously suggested once (5). However, that case had some limitations: the diagnosis of BOOP was based on a transbronchial lung biopsy and the patient had been taking amiodarone, which can cause adverse pulmonary effects, including BOOP (6, 7).…”

Section: Discussionmentioning

confidence: 99%

“…Of the five previously reported cases of interstitial pneumonia, four were treated with PTU after the patient developed an allergic reaction to methimazole (2,3,5). Therefore, the development of interstitial pneumonia was thought to be related to an antecedent allergic reaction to methimazole in a patient taking PTU.…”

Section: Discussionmentioning

confidence: 99%

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Propylthiouracil-induced Bronchiolitis Obliterans Organizing Pneumonia

Lee

Choi

et al. 2013

Intern. Med.

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Propylthiouracil (PTU) is commonly used to treat hyperthyroidism. However, it is also associated with a number of adverse events. In particular, pulmonary complications, although rare, can be serious. Therefore, early detection is paramount. We herein describe a first case of PTU-induced bronchiolitis obliterans organizing pneumonia (BOOP) pathologically confirmed on a surgical lung biopsy. The present case shows that early detection coupled with the immediate withdrawal of PTU can lead to a successful resolution of symptoms and radiographic abnormalities without the need for corticosteroids. Although rare, PTU-induced BOOP should be considered in the differential diagnosis of pulmonary opacity in patients receiving PTU therapy.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionsupporting

confidence: 39%

Section: Introductionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Propylthiouracil-induced Bronchiolitis Obliterans Organizing Pneumonia

Lee

Choi

et al. 2013

Intern. Med.

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Thyroid Hormones, Iodine and Iodides and Antithyroid Drugs

Bilder

2014

Side Effects of Drugs Annual

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Propylthiouracil-induced organizing pneumonia

Xiao¹,

Luo

2019

Medicine

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Rationale: Propylthiouracil (PTU) is a common antithyroid drug which can treat hyperthyroidism effectively. PTU is, however, associated to multiple adverse effects. In rare case, PTU can cause interstitial pneumonia. Patient concerns: A 40-year-old woman presented with dyspnea and was diagnosed with pulmonary infection at the first time. After the treatment with moxifloxacin, her symptoms still got worse. Diagnosis: The lung tissues biopsy confirmed the diagnosis of organizing pneumonia (OP) and the administration of PTU suggested the diagnosis of PTU-induced OP. Intervention: Withdrawal of PTU and the administration of methylprednisolone. Outcomes: The patient's symptoms relieved significantly 1 month later and lung computed tomography (CT) scan also demonstrated significant reduction of lung lesions. Lessons: Here we report the first case of histologically confirmed OP induced by PTU and conduct a literature review of the cases of PTU-induced interstitial pneumonia. The awareness of PTU-induced OP can help physicians reduce the possibility of misdiagnosis.

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Propylthiouracil-Induced Interstitial Pneumonia in a Caucasian Woman with Amiodarone-Induced Thyrotoxicosis

Cited by 4 publications

References 19 publications

Propylthiouracil-induced Bronchiolitis Obliterans Organizing Pneumonia

Propylthiouracil-induced Bronchiolitis Obliterans Organizing Pneumonia

Thyroid Hormones, Iodine and Iodides and Antithyroid Drugs

Propylthiouracil-induced organizing pneumonia

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