A Malonic Ester Synthesis with Acid Chlorides. The Homologation of Oioic Acids

Application of Meldrum's Acid in Natural Product Synthesis. Synthesis of Ar-Turmerone and α-Curcumene

“…In another approach to 6, we planned the acylation of key intermediate (3); which would demonstrate the utility of Meldrum's acid (1) in the synthesis of desired ketones. The reaction in fact, represents the stepwise monoalkylation 27 and acylation [34][35][36] of Meldrum's acid. The key intermediate 3 was condensed with 3,3-dimethylacryloyl chloride in dichloromethane and pyridine to give the alkyl acyl Meldrum's acid 7.…”

Azulenic ß diketones. Synthesis, properties and five membered aromatic heterocyles building

“…modified this procedure, replacing the difficultly available malonyl dibromide by a mixture of malonyl dichloride and gaseous HBr. The subsequent reaction of 3 with Meldrum's ester, 4, 10 yielded the diketone 1 in a low yield (~10 %). A low yield (also under 10%) also was obtained when the lithium salt of acetylacetic acid was reacted with azulene in the presence of oxalyl chloride (Scheme 1).…”