A malignant glomus tumour in the foot of a horse

Brounts, Sabrina H.; Adams, Stephen B.; Vemireddi, Vimala; Holland, C. H.

doi:10.2746/095777308x258838

Cited by 10 publications

(16 citation statements)

References 15 publications

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“…In conclusion, glomus tumours are rare in horses. The clinical history should indicate the possibility of a glomus tumour, as pain was associated with the tumour in all three animals in this series and in the previously documented case 6 . Based on the small number of cases identified to date, glomus tumours in horses may have a higher potential for malignant behaviour when compared with the human counterpart.…”

Section: Discussionmentioning

confidence: 62%

“…More cases must be collected in order to determine whether head and neck are possible predilection sites for glomus tumours in horses. The previously reported glomus tumour in a horse occurred within the third phalanx, deep to the hoof wall, the equine equivalent of a more common location (subungual) for these tumours in humans 6 . The distribution of normal glomus bodies in horses has not been well characterized.…”

Section: Discussionmentioning

confidence: 93%

“…Only one recent case in a dog was classified as malignant 3 . In contrast, the only glomus tumour previously described in a horse was malignant, based on local aggressiveness and postsurgical recurrence; this tumour otherwise had a similar presentation to those in humans, occurring as an osteolytic lesion within the third phalanx deep to the hoof wall 6 …”

Section: Introductionmentioning

confidence: 98%

“…Glomus tumours are rare in domestic animals, although their occurrence has been increasingly recognized and described in several case reports in dogs, a cat, a horse and a cow 1–7 . These tumours are thought to arise from modified smooth muscle cells of the glomus body, a type of arteriovenous anastomosis or shunt, which is involved in regulating temperature 8,9 .…”

Section: Introductionmentioning

confidence: 99%

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Glomus tumours in the skin and subcutis of three horses

Burns

McElliott

Ortega

et al. 2011

Veterinary Dermatology

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Three horses presented with variably painful, nonulcerated masses of the head or neck that were diagnosed as glomus tumours. Grossly, they were fleshy, pink to tan masses ranging from 0.4 to 9 cm in diameter, involving either the deep dermis and subcutis or the subcutis and underlying skeletal muscle. Microscopically, neoplastic epithelioid cells were arranged in sheets, cords and packets within lobules. The neoplastic cells frequently abutted and formed nodular bulges into large endothelium-lined vascular spaces, especially around the tumour periphery. Large nerve branches were associated with each tumour. As determined by immunohistochemistry, the neoplastic cells consistently expressed α-smooth muscle actin and vimentin, and some cells in two of the cases expressed desmin. A laminin- or collagen IV-positive basement membrane was demonstrated around individual tumour cells or small groups of cells in all three cases. Morphological features and immunohistochemistry supported the diagnosis of glomus tumour, most consistent with the solid type in humans. Applying a classification system used in humans, two of these tumours met criteria of malignancy (glomangiosarcomas). One horse was euthanized due to complications associated with recurrence and treatment-related necrosis and secondary infection.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Glomus tumours in the skin and subcutis of three horses

Burns

McElliott

Ortega

et al. 2011

Veterinary Dermatology

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show abstract

“…

In this issue, Brounts et al (2008) present a case report describing and verifying for the first time the presence of a glomus tumour interposed between third phalanx and hoof wall. Submural tumours and masses (keratomas, squamous cell carcinoma, malignant melanoma and mast cell tumour) are uncommon, but a given practice or practitioner is likely to encounter such.

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mentioning

confidence: 89%