A magnetically guided anti-cancer drug delivery system using porous FePt capsules

Fuchigami, Teruaki; Kawamura, Ryo; Kitamoto, Yoshitaka; Nakagawa, Masaru; Namiki, Yoshihisa

doi:10.1016/j.biomaterials.2011.11.016

Cited by 71 publications

(46 citation statements)

References 23 publications

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“…The cell lines were incubated under a magnetic field with Fe-Pt-Dox capsules and with just doxorubicin. The results showed that the Fe-Pt-Dox capsules were guided under magnetic field and prevented the cancer cell growth of both cell lines as well as destroying over 70% of the cancer cell lines [167].…”

Section: Fe-pt Nanoparticles In Targeted Drug Delivery and Cancer Thementioning

confidence: 88%

“…Fuchigami et al [167] researched the effect of magnetic porous Fe-Pt nanoparticles loaded with an anticancer drug for targeted drug delivery on gastric and lung cancer cell lines. Porous Fe-Pt nanoparticles were fabricated by a hydrothermal treatment of Fe-Pt/PDDA Silica composite particles which resulted in the formation of a hollow capsule with a Fe-Pt nanoparticle shell.…”

Section: Fe-pt Nanoparticles In Targeted Drug Delivery and Cancer Thementioning

confidence: 99%

“…Bimetallic nanoparticles such as iron platinum (Fe-Pt) possess unique chemical and magnetic properties such as chemical stability, superparamagnetisation, high Curie temperature, high saturation magnetisation and high X-ray absorption [155][156][157][158]. These properties make them attractive materials for use in hyperthermia treatment [159,160], MRI contrast agents [161][162][163][164][165][166], drug delivery [167][168][169][170][171] and biosensors [172] which will be discussed in more detail in Section 4.…”

Section: Bimetallic or Alloy Nanoparticlesmentioning

confidence: 99%

“…It is due to these properties that research for the potential uses of Fe-Pt nanoparticles in biomedical applications such hyperthermia [159,160] as contrast agents for MRI [161][162][163][164][165][166], drug delivery/cancer therapy [167][168][169][170][171] and biosensors [172] has increased. In this review, we will discuss the use of Fe-Pt nanoparticles in targeted drug delivery, cancer therapy, MRI contrast agents as well as its possible use in magnetic hyperthermia.…”

Section: Introductionmentioning

confidence: 99%

“…This review investigates other nanosystems such as metallic nanoparticles like gold (Au) [112][113][114][115][116][117][118][119][120][121][122][123][124][125][126][127][128][129][130] and silver (Ag) , bimetallic nanoparticles like iron cobalt (Fe-Co) [78][79][80][92][93][94][95][96][97]108,109] and iron platinum (Fe-Pt) [155][156][157][158][159][160][161][162][163][164][165][166][167][168][169][170][171][172] and metal oxides including titanium dioxide (TiO 2 ) [1...…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Nanoparticles in biomedical applications

McNamara

Tofail

2016

Advances in Physics: X

284

261

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Section: Fe-pt Nanoparticles In Targeted Drug Delivery and Cancer Thementioning

confidence: 88%

Section: Fe-pt Nanoparticles In Targeted Drug Delivery and Cancer Thementioning

confidence: 99%

Section: Bimetallic or Alloy Nanoparticlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Nanoparticles in biomedical applications

McNamara

Tofail

2016

Advances in Physics: X

284

261

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Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

Kankala

Zhang

Wang

et al. 2017

Adv Healthcare Materials

203

184

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During the past few decades, supercritical fluid (SCF) has emerged as an effective alternative for many traditional pharmaceutical manufacturing processes. Operating active pharmaceutical ingredients (APIs) alone or in combination with various biodegradable polymeric carriers in high-pressure conditions provides enhanced features with respect to their physical properties such as bioavailability enhancement, is of relevance to the application of SCF in the pharmaceutical industry. Herein, recent advances in drug delivery systems manufactured using the SCF technology are reviewed. We provide a brief description of the history, principle, and various preparation methods involved in the SCF technology. Next, we aim to give a brief overview, which provides an emphasis and discussion of recent reports using supercritical carbon dioxide (SC-CO2) for fabrication of polymeric carriers, for applications in areas related to drug delivery, tissue engineering, bio-imaging, and other biomedical applications. We finally summarize with perspectives.

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Prussian Blue Derived Nanoporous Iron Oxides as Anticancer Drug Carriers for Magnetic‐Guided Chemotherapy

Zakaria

Belik

Liu

et al. 2015

Chemistry An Asian Journal

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New nanoporous iron oxide nanoparticles with superparamagnetic behavior were successfully synthesized from Prussian blue (PB) nanocubes through a thermal conversion method and applied to the intracellular drug-delivery systems (DDS) of bladder cancer cells (i.e., T24) with controlled release and magnetic guiding properties. The results of the MTT assay and confocal laser scanning microscopy indicate that the synthesized iron oxide nanoparticles were successfully uptaken by T24 cells with excellent biocompatibility. An anticancer drug, that is, cisplatin, was used as a model drug, and its loading/release behavior was investigated. The intracellular drug delivery efficiency was greatly enhanced for the cisplatin-loaded, PB-derived, magnetic-guided drug-delivery system compared with the non-drug case. The synthesized nanomaterials show great potential as drug vehicles with high biocompatibility, controlled release, and magnetic targeting features for future intracellular DDS.

show abstract

A magnetically guided anti-cancer drug delivery system using porous FePt capsules

Cited by 71 publications

References 23 publications

Nanoparticles in biomedical applications

Nanoparticles in biomedical applications

Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

Prussian Blue Derived Nanoporous Iron Oxides as Anticancer Drug Carriers for Magnetic‐Guided Chemotherapy

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