A magnetic-separation-based homogeneous immunosensor for the detection of deoxynivalenol coupled with a nano-affinity cleaning up for LC-MS/MS confirmation

Guo, Jiao; Wei, Tai-long; He, Qinghua; Cheng, Jiujun; Qiu, Xiuzhen; Liu, Wang-Pei; Lan, Xian-Quan; Chen, Lu-Fen; Guo, Min

doi:10.1080/09540105.2021.1886254

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…To explore the influence of Ab orientation on the analytical performance of fabricated immunosensors for mycotoxins detection, staphylococcus proteins A (SpA) and streptococcal protein G (SpG) are the preferred options due to their high affinity toward the fragment crystallizable (Fc) region of Abs (Guo, Wei et al, 2021;Höfs et al, 2021). Mao et al (2022) compared two Ab immo-bilization strategies on the analytical characteristics of competitive LFIA against AFB 1 .…”

Section: 12mentioning

confidence: 99%

Magnetic nanoparticle‐based immunosensors and aptasensors for mycotoxin detection in foodstuffs: An update

Gao,

Zhou,

Zhang

et al. 2023

Comp Rev Food Sci Food Safe

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Mycotoxin contamination of food crops is a global challenge due to their unpredictable occurrence and severe adverse health effects on humans. Therefore, it is of great importance to develop effective tools to prevent the accumulation of mycotoxins through the food chain. The use of magnetic nanoparticle (MNP)‐assisted biosensors for detecting mycotoxin in complex foodstuffs has garnered great interest due to the significantly enhanced sensitivity and accuracy. Within such a context, this review includes the fundamentals and recent advances (2020–2023) in the area of mycotoxin monitoring in food matrices using MNP‐based aptasensors and immunosensors. In this review, we start by providing a comprehensive introduction to the design of immunosensors (natural antibody or nanobody, random or site‐oriented immobilization) and aptasensors (techniques for aptamer selection, characterization, and truncation). Meanwhile, special attention is paid to the multifunctionalities of MNPs (recoverable adsorbent, versatile carrier, and signal indicator) in preparing mycotoxin‐specific biosensors. Further, the contribution of MNPs to the multiplexing determination of various mycotoxins is summarized. Finally, challenges and future perspectives for the practical applications of MNP‐assisted biosensors are also discussed. The progress and updates of MNP‐based biosensors shown in this review are expected to offer readers valuable insights about the design of MNP‐based tools for the effective detection of mycotoxins in practical applications.

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Section: 12mentioning

confidence: 99%

Magnetic nanoparticle‐based immunosensors and aptasensors for mycotoxin detection in foodstuffs: An update

Gao,

Zhou,

Zhang

et al. 2023

Comp Rev Food Sci Food Safe

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show abstract

One-step time-resolved fluorescence microsphere immunochromatographic test strip for quantitative and simultaneous detection of DON and ZEN

et al. 2021

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Development and validation of a reliable LC-MS/MS method for simultaneous determination of deoxynivalenol and T-2 toxin in maize and oats

Tahoun

Gab-Allah

Yamani

et al. 2021

Microchemical Journal

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A magnetic-separation-based homogeneous immunosensor for the detection of deoxynivalenol coupled with a nano-affinity cleaning up for LC-MS/MS confirmation

Abstract: Guo (2021) A magnetic-separation-based homogeneous immunosensor for the detection of deoxynivalenol coupled with a nano-affinity cleaning up for LC-MS/MS confirmation,

Cited by 4 publications

References 35 publications

Magnetic nanoparticle‐based immunosensors and aptasensors for mycotoxin detection in foodstuffs: An update

Magnetic nanoparticle‐based immunosensors and aptasensors for mycotoxin detection in foodstuffs: An update

One-step time-resolved fluorescence microsphere immunochromatographic test strip for quantitative and simultaneous detection of DON and ZEN

Development and validation of a reliable LC-MS/MS method for simultaneous determination of deoxynivalenol and T-2 toxin in maize and oats

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