A magnetic resonance imaging evaluation of histamine-mediated allergic response in the guinea pig nasopharynx

Sherwood, J; Hutt, Douglas A.; Kreutner, William; Morton, James; Chapman, Richard W.

doi:10.1016/0091-6749(93)90122-v

Cited by 17 publications

(4 citation statements)

References 27 publications

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“…However, most of these techniques are highly invasive and usually involve isolation of the nasal cavity from influences of the rest of the airway (14,19,29). Magnetic resonance imaging (8,30) is noninvasive and provides accurate and reproducible images of the nasopharynx, but it requires expensive equipment and highly trained personnel.…”

Section: Discussionmentioning

confidence: 99%

Measurement of nasal patency in anesthetized and conscious dogs

Koss

Hey³

et al. 2002

Journal of Applied Physiology

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Experiments were undertaken to characterize a noninvasive chronic, model of nasal congestion in which nasal patency is measured using acoustic rhinometry. Compound 48/80 was administered intranasally to elicit nasal congestion in five beagle dogs either by syringe (0.5 ml) in thiopental sodium-anesthetized animals or as a mist (0.25 ml) in the same animals in the conscious state. Effects of mast cell degranulation on nasal cavity volume as well as on minimal cross-sectional area (A(min)) and intranasal distance to A(min) (D(min)) were studied. Compound 48/80 caused a dose-related decrease in nasal cavity volume and A(min) together with a variable increase in D(min). Maximal responses were seen at 90-120 min. Compound 48/80 was less effective in producing nasal congestion in conscious animals, which also had significantly larger basal nasal cavity volumes. These results demonstrate the utility of using acoustic rhinometry to measure parameters of nasal patency in dogs and suggest that this model may prove useful in studies of the actions of decongestant drugs.

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Section: Discussionmentioning

confidence: 99%

Measurement of nasal patency in anesthetized and conscious dogs

Koss

Hey³

et al. 2002

Journal of Applied Physiology

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“…]5%) 0.040 mL (-58.02%) 0.052 mL (-41.08%) 0.05] mL (-40.05%) 0.049 ± 0.003 mL * (-42.76 ± 3.32%) line, which is a potent secretagogue of nasal glands, has no effect. 9 On the other hand, mucosal thickening after antigen challenge may be a result of increased permeability of nasal mucosal blood vessels. Our previous study demonstrated that antigen increased dye leakage into the nasal cavity of allergic guinea pigs.…”

Section: Discussionmentioning

confidence: 99%

Acoustic Rhinometry Evaluation of Nasal Response to Histamine and Antigen in Guinea Pigs

Ohkawa

Ukai

Miyahara

et al. 1999

American Journal of Rhinology

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The effects of antigen and histamine on the changes of nasal passage patency in 112 guinea pigs with or without allergic rhinitis were evaluated by acoustic rhinometry. The percent change of volume from the nostril to 2 cm into the nasal cavity showed significant reduction of 31.10 +/- 4.11% at 10 minutes and 31.10 +/- 4.11% at 30 minutes after antigen challenge in sensitized guinea pigs. The pretreatment with ketotifen, an H1-histamine receptor antagonist as well as mast cell stabilizing drug, blocked dose-dependently the effects of antigen on those changes in volume. Furthermore, instillation of 10(4) micrograms/mL histamine reduced significantly nasal passage patency to 33.77 +/- 4.63% at 10 minutes and 42.76 +/- 3.32% at 30 minutes after challenge compared with that before challenge and ketotifen inhibited the effects of histamine, which indicated that histamine is an important mediator of allergic upper airway responses in guinea pigs. These results show that acoustic rhinometry is a useful technique to assess the nasal blockade in allergic guinea pigs.

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“…3,4 The 3 major causes of the nasal blockage are thought to be dilitation of capacitance vessels in the nasal septum and turbinates, edematous swelling of nasal membranes, and the direct result of secretions. [5][6][7][8] The mechanisms underlying the development of bronchial asthma have been analyzed, measuring lower airway function. By using murine strains with targeted mutations of an array of relevant genes, the role of a number of factors contributing to the pathogenesis of lower airway hyperresponsiveness in asthma has been reported.…”

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confidence: 99%