A macrophage activation marker chitotriosidase in women with PCOS: does low-grade chronic inflammation in PCOS relate to PCOS itself or obesity?

Alanbay, İbrahim; Ercan, Cihangir Mutlu; Sakıncı, Mehmet; Çoksüer, Hakan; Öztürk, Mustafa; Tapan, Serkan

doi:10.1007/s00404-012-2425-0

Cited by 40 publications

(28 citation statements)

References 39 publications

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“…We firstly clarified that TGF-β and TNF-α induce PAI-1 mRNA expression and activity. PCOS is described as a low-grade chronic inflammatory state mainly triggered by an increase in activated macrophage infiltration in visceral fat 19 . It has also been reported that aberrant expression of TGF-β and TNF-α is related to PCOS, and macrophages are known to primarily secrete these cytokines 17, 18, 20, 21 .…”

Section: Discussionmentioning

confidence: 99%

“…PCOS is described as a low-grade chronic inflammatory state mainly triggered by an increase in activated macrophage infiltration in visceral fat. 19 It has also been reported that aberrant expression of TGFβ and TNFα is related to PCOS, and macrophages are known to primarily secrete these cytokines. 17,18,20,21 In the present study, simultaneous addition of TGFβ and TNFα had a synergistic effect on PAI-1 mRNA expression and activity, which was completely suppressed by a combination of ALK-5 and p38 MAPK inhibitors.…”

Section: Discussionmentioning

confidence: 99%

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PAI‐1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF‐β and TNF‐α in mononuclear cells by insulin‐sensitizing drugs

Yamada-Nomoto

Yokosuka

Akiyama

et al. 2017

American J Rep Immunol

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Problem Plasminogen activator inhibitor-1 (PAI-1) is elevated in women with polycystic ovary syndrome (PCOS), but the regulation in granulosa cells (GCs) is unclear. Method of Study PAI-1 expression in PCOS ovaries were investigated immunohistologically. PAI-1 expressions in HGrC1, a human GC cell line, were investigated at mRNA and activity levels. The expressions of TGF-β and TNF-α in peritoneal fluid mononuclear cells (PFMC) were measured with quantitative PCR. Results Little PAI-1 expression is observed in healthy GCs whereas GCs of PCOS and atretic follicle exhibit distinct expression in vivo. In vitro study using HGrC1 shows that TGF-β and TNF-α increase PAI-1 mRNA and its activity, and both together exhibit a synergistic effect. The expression of PAI-1 mRNA is suppressed by simvastatin. Moreover, insulin sensitizing drugs (metformin, pioglitazone and rosiglitazone) suppress LPS-induced TGF-β and TNF-α mRNA expression in PFMC. Conclusions Statin and insulin sensitizing drugs may provide a potential therapy for PCOS via down-regulation of PAI-1 expression in GCs and down-regulation of TGF-β and TNF-α expression in PFMC, respectively.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

PAI‐1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF‐β and TNF‐α in mononuclear cells by insulin‐sensitizing drugs

Yamada-Nomoto

Yokosuka

Akiyama

et al. 2017

American J Rep Immunol

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“…Therefore, ChT is considered as a biomarker of macrophage activation [6]. Human ChT is associated with several infectious and inflammatory diseases [7][8].…”

Section: Introductionmentioning

confidence: 99%

Chitotirosidase and prolidase in tinea pedis: A preliminary study

Doğan¹,

Hayta²

2017

Med-Science

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Dermatophyte infections are superficial fungal infections. Tinea pedis is a dermatophyte infection of the feet and interdigital spaces. An evaluation was made of the chitotriosidase (ChT) concentrations, prolidase activity and the possible association between these biomarkers in tinea pedis. Study subjects were comprised of 42 patients with tinea pedis and 40 healthy subjects. Serum ChT concentrations and prolidase activity were determined in study population. Higher ChT concentrations were found in patients than controls (p < 0.001). We did not find any difference between groups in terms of prolidase activity (p = 0.162). We also did not found any correlation between ChT and prolidase activity. ChT seems to have roles during the inflammatory conditions in patients with tinea pedis. Whereas prolidase activity is not associated with the tinea pedis.

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“…This enzyme is mainly secreted from activated and differentiated macrophages, therefore, ChT is a marker of macrophage activation (9). Human ChT is associated with Gaucher’s disease, lysosomal storage disorders, sarcoidosis, Crimean Congo hemorrhagic fever, and beta-thalassemia (10111213).…”

Section: Introductionmentioning

confidence: 99%

Decreased Chitotriosidase Activity and Levels in Familial Mediterranean Fever

et al. 2016

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Different studies have demonstrated changes in chitotriosidase (ChT) activity and concentrations in multiple diseases. However, changes in ChT activity and concentrations have not been concurrently evaluated in patients with Familial Mediterranean Fever (FMF). In this study, we analyzed the changes in serum ChT activity and concentrations in patients with FMF. The study included a total of 80 patients with FMF and 80 healthy controls. ChT enzyme activity and concentrations were measured and then compared between the groups. ChT activity was measured by using fluorometric ELISA and ChT concentrations were measured by using colorimetric ELISA methods. The median ChT activity was 10.00 (6.00–15.00) nmol/mL/hr in the patients and 14.00 (6.25–20.75) nmol/mL/hr in the controls. There was a statistically significant difference in the ChT activity between the controls and patients (P = 0.027). The median ChT concentrations were 65.40 (46.20–84.92) pg/mL and 125.00 (75.72–143.95) pg/mL in the patients and controls, respectively (P < 0.001), which were expressed as median percentiles (25th–75th). Additionally, we found no correlation between C-reactive protein and ChT activity (P = 0.978, r = 0.003) and concentrations (P = 0.446, r = −0.87). Serum ChT enzyme activity and concentrations may not be considered as a biomarker in FMF patients taking colchicine. New studies are needed to evaluate the changes of enzyme activity and concentration in colchicine-negative patients.

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A macrophage activation marker chitotriosidase in women with PCOS: does low-grade chronic inflammation in PCOS relate to PCOS itself or obesity?

Cited by 40 publications

References 39 publications

PAI‐1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF‐β and TNF‐α in mononuclear cells by insulin‐sensitizing drugs

PAI‐1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF‐β and TNF‐α in mononuclear cells by insulin‐sensitizing drugs

Chitotirosidase and prolidase in tinea pedis: A preliminary study

Decreased Chitotriosidase Activity and Levels in Familial Mediterranean Fever

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