A mace-like heterostructural enriched injectable hydrogel composite for on-demand promotion of diabetic wound healing

Wang, Li; Hussain, Zahid; Zheng, Penghui; Zhang, Yajie; Cao, Yi; Gao, Tong; Zhang, Zhuangzhuang; Zhang, Yuehu; Pei, Renjun

doi:10.1039/d2tb02403a

Cited by 17 publications

(21 citation statements)

References 46 publications

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“…In a recent study, Pei et al introduced a silk fibroin-hyaluronic acid based injectable hydrogel encapsulated with heterostructural NPs (gAu-CuS HSs) for promoting diabetic wound healing. [120] Due to the rough surface of gAu-CuS HSs, local injection of this hydrogel could achieve an excellent hemostatic effect, and during the inflammation phase, the unusual mace-like rough structure of NPs could beneficially induce macrophage toward M2 phenotype polarization and ameliorate the excessive inflammation. In the proliferation and remodeling phase, gAu-CuS HSs could enhance angiogenesis and promote cell migration and differentiation to accelerate wound healing.…”

Section: Sustainable and On-demand Effects Of Nanosystems In Promotin...mentioning

confidence: 99%

Reactive Oxygen Species‐Scavenging Nanosystems in the Treatment of Diabetic Wounds

Xiong

Chu

et al. 2023

Adv Healthcare Materials

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Diabetic wounds are characterized by drug‐resistant bacterial infections, biofilm formation, impaired angiogenesis and perfusion, and oxidative damage to the microenvironment. Given their complex nature, diabetic wounds remain a major challenge in clinical practice. Reactive oxygen species (ROS), which have been shown to trigger hyperinflammation and excessive cellular apoptosis, play a pivotal role in the pathogenesis of diabetic wounds. ROS‐scavenging nanosystems have recently emerged as smart and multifunctional nanomedicines with broad synergistic applicability. The documented anti‐inflammatory and pro‐angiogenic ability of ROS‐scavenging treatments predestines these nanosystems as promising options for the treatment of diabetic wounds. Yet, in this context, the therapeutic applicability and efficacy of ROS‐scavenging nanosystems remain to be elucidated. Herein, the role of ROS in diabetic wounds is deciphered, and the properties and strengths of nanosystems with ROS‐scavenging capacity for the treatment of diabetic wounds are summarized. In addition, the current challenges of such nanosystems and their potential future directions are discussed through a clinical‐translational lens.

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Section: Sustainable and On-demand Effects Of Nanosystems In Promotin...mentioning

confidence: 99%

Reactive Oxygen Species‐Scavenging Nanosystems in the Treatment of Diabetic Wounds

Xiong

Chu

et al. 2023

Adv Healthcare Materials

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“…At the same time, it can undergo spatial resonance energy transfer under 808 nm laser irradiation, thereby generating ROS to destroy bacteria. 139…”

Section: Smart Hydrogels For Wound Therapymentioning

confidence: 99%

Recent advances of hydrogels as smart dressings for diabetic wounds

Wang,

Yang,

Zhao

et al. 2024

J. Mater. Chem. B

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“…In this context, antimicrobial agents play a crucial role in clearing up infection at the wound site, reducing the risk of necrosis and lower limb amputation. Apart from antibiotics [11,12], newer agents such as antimicrobial peptides and peptide-based polymers [13], phytochemicals [14,15] and inorganic nanomaterials such as silver nanoclusters [16], Au-based nanoparticles (NPs) [17], and metal oxide NPs, e.g. zinc oxide [15], magnesium oxide, cerium oxide and ferric oxide NPs [18] are currently emerging as effective bioactives capable of preventing infection, reducing bacterial resistance and promoting healing of acute and diabetic wounds.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing

Metwally,

El-Habashy,

El-Hosseiny

et al. 2023

Biofabrication

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There is a constant demand for novel materials/biomedical devices to accelerate the healing of hard-to-heal wounds. Herein, an innovative 3D-printed bioinspired construct was developed as an antibacterial/regenerative scaffold for diabetic wound healing. Hyaluronic/chitosan (HA/CS) ink was used to fabricate a bilayer scaffold comprising a dense plain hydrogel layer topping an antibacterial/regenerative nanofibrous layer obtained by incorporating the hydrogel with polylactic acid nanofibrous microspheres (MS). These were embedded with nano ZnO (ZNP) or didecyldimethylammonium bromide (DDAB)-treated ZNP (D-ZNP) to generate the antibacterial/healing nano/micro hybrid biomaterials, Z-MS@scaffold and DZ-MS@scaffold. Plain and composite scaffolds incorporating blank MS (blank MS@scaffold) or MS-free ZNP@scaffold and D-ZNP@scaffold were used for comparison. 3D printed bilayer constructs with customizable porosity were obtained as verified by SEM. The DZ-MS@scaffold exhibited the largest total pore area as well as the highest water-uptake capacity and in vitro antibacterial activity. Treatment of Staphylococcus aureus-infected full thickness diabetic wounds in rats indicated superiority of DZ-MS@scaffold as evidenced by multiple assessments. The scaffold afforded 95% wound-closure, infection suppression, effective regulation of healing-associated biomarkers as well as regeneration of skin structure in 14 d. On the other hand, healing of non-diabetic acute wounds was effectively accelerated by the simpler less porous Z-MS@scaffold. Information is provided for the first-time on the 3D printing of nanofibrous scaffolds using non-electrospun injectable bioactive nano/micro particulate constructs, an innovative ZNP-functionalized 3D-printed formulation and the distinct bioactivity of D-ZNP as a powerful antibacterial/wound healing promotor. In addition, findings underscored the crucial role of nanofibrous-MS carrier in enhancing the physicochemical, antibacterial, and wound regenerative properties of DDAB-nano ZnO. In conclusion, innovative 3D-printed DZ-MS@scaffold merging the MS-boosted multiple functionalities of ZNP and DDAB, the structural characteristics of nanofibrous MS in addition to those of the 3D-printed bilayer scaffold, provide a versatile bioactive material platform for diabetic wound healing and other biomedical applications.

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A mace-like heterostructural enriched injectable hydrogel composite for on-demand promotion of diabetic wound healing

Abstract: Wound healing is a multifaceted process that possesses hemostasis, inflammation, proliferation, and remodeling stages. Diabetic wounds affect the transition of the organized phases and result in delayed healing due to...

Cited by 17 publications

References 46 publications

Reactive Oxygen Species‐Scavenging Nanosystems in the Treatment of Diabetic Wounds

Reactive Oxygen Species‐Scavenging Nanosystems in the Treatment of Diabetic Wounds

Recent advances of hydrogels as smart dressings for diabetic wounds

Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing

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