A low waste route to large scale enzymatic resolution

An efficient stereoselective synthesis of difluoromethylated alkenes in a microreactor

“…Especially, there is much interest in the development of microreactors for chemical processing [3], because the benefits would include arithmetic scale-up and problems of the safe handling and/or temperature control. To date, the studies of the construction of fluorinated materials in microreactors have been based on four methods: (1) the direct fluorination with elemental fluorine [4], (2) trifluoromethylation with trifluoromethyl-(trimethyl)silane [5], (3) the synthesis of a-fluoro-a,b-unsaturated esters with the Hörner-Wadsworth-Emmons reaction [5], and (4) Michael addition reaction of CF 3 -containing acrylates [5]. Furthermore, difluoromethyl substitution on an organic molecule often confers bioactivity on these compounds and can serve as a diagnostic handle for functionalized materials [6].…”

“…The challenge in fluorine chemistry to develop new products, practical processes, reaction media, conditions and/or utility of materials based on the idea of green chemistry is having one of the most important issues [1,2]. Especially, there is much interest in the development of microreactors for chemical processing [3], because the benefits would include arithmetic scale-up and problems of the safe handling and/or temperature control.…”

Ionic Liquid-Promoted Regiospecific Friedlander Annulation: Novel Synthesis of Quinolines and Fused Polycyclic Quinolines

“…In recent years, studies of low waste routes and reusable reaction media for enhanced selectivity and energy minimization are the key interests of synthetic organic chemists world over . In this context, in recent times, the use of room-temperature ionic liquids (ILs) as “green” solvents in organic synthetic processes has gained considerable importance due to their solvating ability, negligible vapor pressure, and easy recyclability .…”

Lewis acidic (choline chloride.3ZnCl2) ionic liquid: A green and recyclable catalyst for the one-pot synthesis of 4-((3-indolyl)(aryl)methyl)-N,N-dimethylanilines under solvent-free conditions

“…In the present era of chemical synthesis, avoidance of toxic solvents and reagents, reduction of waste and creating reusable reaction media are the key interests of synthetic organic chemists world over. 1,2 In this context, ionic liquids are the versatile alternative, as a result of their green credentials such as undetectable vapour pressure, reusability and high thermal stability. 3,4 Recently, imidazolium-based ionic liquids have been extensively used as solvents and catalysts in organic synthesis.…”