2010
DOI: 10.1590/s0100-879x2010007500061
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A low concentration of ouabain (0.18 µg/kg) enhances hypertension in spontaneously hypertensive rats by inhibiting the Na+ pump and activating the renin-angiotensin system

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Cited by 7 publications
(12 citation statements)
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“…On the other hand, the central mechanism described above suggests that ouabain stimulates the brain renin-angiotensin system, leading to the production of angiotensin II, which further increases sympathetic tone and ultimately increases arterial blood pressure (47). We also found that the increases in systolic and diastolic blood pressure induced by low-dose ouabain (~0.3 nmol/kg) were blocked completely by pretreatment (iv) with 10 mg/kg losartan, although these increases were not affected by ganglionic blockade with 5 mg/kg hexamethonium, suggesting that ouabain, at least at this concentration, does not act on preganglionic neurons (28,31). On the other hand, the increase of blood pressure induced by 0.18 µg/kg ouabain in L-NAME-hypertensive rats is blocked by hexamethonium (29).…”
Section: Acute Effects Of Picomole Quantities Of Ouabain On Vascular mentioning
confidence: 59%
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“…On the other hand, the central mechanism described above suggests that ouabain stimulates the brain renin-angiotensin system, leading to the production of angiotensin II, which further increases sympathetic tone and ultimately increases arterial blood pressure (47). We also found that the increases in systolic and diastolic blood pressure induced by low-dose ouabain (~0.3 nmol/kg) were blocked completely by pretreatment (iv) with 10 mg/kg losartan, although these increases were not affected by ganglionic blockade with 5 mg/kg hexamethonium, suggesting that ouabain, at least at this concentration, does not act on preganglionic neurons (28,31). On the other hand, the increase of blood pressure induced by 0.18 µg/kg ouabain in L-NAME-hypertensive rats is blocked by hexamethonium (29).…”
Section: Acute Effects Of Picomole Quantities Of Ouabain On Vascular mentioning
confidence: 59%
“…In some rat models of hypertension, including the SHR model (28), renovascular hypertension and L-NAMEinduced hypertension (29), acute ouabain administration increases blood pressure, whereas no change in blood pressure is observed in normotensive rats (14,30,31). These results suggest that the effects of ouabain are amplified in hypertensive conditions.…”
Section: Acute Effects Of Picomole Quantities Of Ouabain On Vascular mentioning
confidence: 96%
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“…The relative participation of the SR is more important for post-rest contractions than for steady state contractions. Pause intervals of various durations (15,30 and 60 s) were tested and the results were presented as the relative potentiation (the amplitude of post-rest contractions divided by steady-state contractions) to normalize the data from different preparations. 4.…”
Section: Isolated Papillary Musclesmentioning
confidence: 99%