A longitudinal study shows intermittent colonization by Staphylococcus aureus with a high genetic diversity in hemodialysis patients

Vanegas, Johanna M.; Salazar-Ospina, Lorena; Gallego, Marlon Alexis; Jiménez, J. Natalia

doi:10.1016/j.ijmm.2020.151471

Cited by 8 publications

(5 citation statements)

References 34 publications

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“…The MRSA strains included in this study showed resistance profiles similar to those of clinical isolates circulating in hospital settings in Colombia [ 30 , 31 ]. S. aureus , including MRSA strains, has been reported to be one of the leading causes of nosocomial infections worldwide, especially among patients in surgery, undergoing hemodialysis, and in ICU units, because of the long-term use of venous and urinary catheters [ 32 , 33 , 34 ]. The surfaces of some items in these units, such as beds, operating tables, infusion pumps, and electrocardiography devices, among others, have been found to be contaminated with MRSA strains, which could lead to cross-contamination via the hands of healthcare personnel [ 34 , 35 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

Efficacy of Vaporized Hydrogen Peroxide Combined with Silver Ions against Multidrug-Resistant Gram-Negative and Gram-Positive Clinical Isolates

Sánchez

Rojas-Abadía

Ríos-Acevedo

et al. 2022

IJMS

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Antimicrobial resistance (AMR) is a serious public health problem that results in high morbidity and mortality rates. In particular, multidrug-resistant (MDR) strains circulating in hospital settings pose a major threat as they are associated with serious nosocomial infections. Therefore, regular cleaning and disinfection procedures, usually using chemical disinfectants, must be implemented in these facilities. Hydrogen peroxide (HP)-based disinfectants have proven high microbicidal activity and several comparative advantages over conventional disinfectants. We assessed the in vitro biocidal activity of an 8% HP solution combined with 30 mg/L silver ions (HP + Ag) against MDR clinical isolates of Klebsiella pneumoniae (MDRKp) and Pseudomonas aeruginosa (MDRPa), and methicillin-resistant Staphylococcus aureus (MRSA). Accordingly, the in vitro antibacterial activity was determined using the macrodilution method, and the efficacy was determined for 30 min in terms of (1) activity on bacteria in suspension and (2) activity on surfaces using vaporized HP + Ag on a 20 cm2 stainless steel surface. A strong bactericidal effect of HP + Ag was observed against MDRKp, MDRPa, and MRSA strains, with minimum inhibitory concentrations and minimum bactericidal concentrations between 362.5 and 5800 mg/L. A strong effect was observed during the 30 min of HP + Ag exposure to the resistant clinical isolates, with over 4-Log10 reduction in CFUs. Regarding the efficacy of the disinfectant on surfaces, bacterial load reductions of >99% were observed. These results suggest that HP + Ag is potentially useful as an effective disinfectant for decontaminating surfaces in hospital settings suspected of contamination with MDR bacteria.

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Section: Resultsmentioning

confidence: 99%

Efficacy of Vaporized Hydrogen Peroxide Combined with Silver Ions against Multidrug-Resistant Gram-Negative and Gram-Positive Clinical Isolates

Sánchez

Rojas-Abadía

Ríos-Acevedo

et al. 2022

IJMS

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“…En relación a la colonización con S. aureus el 93,33% (n=14) presentan infección relacionada al (2,10,46) catéter de hemodiálisis, constituyéndose un factor de riesgo que se ha descrito en la bibliografía . Los enfermos renales en hemodiálisis portadores de S. aureus meticilin resistentes tienen más de 2 veces el riesgo de morir de cualquier cuasa por lo que se recomienda el tratamiento para la (47) descolonización .…”

Section: Discussionunclassified

Risk factors associated with hemodialysis catheter infection in a referral center

Franco

Ovelar

Arévalos

et al. 2022

Rev. virtual Soc. Parag. Med. Int

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“…[7][8][9] Staphylococcus aureus is a frequently reported pathogen responsible for infections in hemodialysis patients. [10][11][12] Chronic kidney disease causes physiological changes that may alter the absorption, distribution, metabolism, and elimination of antibiotics, especially during renal excretion. 13 These pharmacokinetic changes can lead to drug accumulation and toxicity if the doses are not adequately adjusted.…”

Section: Introductionmentioning

confidence: 99%

Population Pharmacokinetics of Vancomycin in Patients Receiving Hemodialysis in a Malian and a French Center and Simulation of the Optimal Loading Dose

Coulibaly

Maire

Guitton

et al. 2023

Therapeutic Drug Monitoring

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Purpose: Vancomycin dosing remains challenging in patients receiving intermittent hemodialysis, especially in developing countries, where access to therapeutic drug monitoring and model-based dose adjustment services is limited. The objectives of this study were to describe vancomycin population PK in patients receiving hemodialysis in a Malian and French center and examine the optimal loading dose of vancomycin in this setting. Methods: Population pharmacokinetic analysis was conducted using Pmetrics in 31 Malian and 27 French hemodialysis patients, having a total of 309 vancomycin plasma concentrations. Structural and covariate analyses were based on goodness-of-fit criteria. The final model was used to perform simulations of the vancomycin loading dose, targeting a daily area under the concentration–time curve (AUC) of 400–600 mg.h/L or trough concentration of 15–20 mg/L at 48 hours. Results: After 48 hours of therapy, 68% of Malian and 63% of French patients exhibited a daily AUC of <400. The final model was a 2-compartment model, with hemodialysis influencing vancomycin elimination and age influencing the vancomycin volume distribution. Younger Malian patients exhibited a lower distribution volume than French patients. Dosing simulation suggested that loading doses of 1500, 2000, and 2500 mg would be required to minimize underexposure in patients aged 30, 50, and 70 years, respectively. Conclusions: In this study, a low AUC was frequently observed in hemodialysis patients in Mali and France after a standard vancomycin loading dose. A larger dose is necessary to achieve the currently recommended AUC target. However, the proposed dosing algorithm requires further clinical evaluation.

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A longitudinal study shows intermittent colonization by Staphylococcus aureus with a high genetic diversity in hemodialysis patients

Cited by 8 publications

References 34 publications

Efficacy of Vaporized Hydrogen Peroxide Combined with Silver Ions against Multidrug-Resistant Gram-Negative and Gram-Positive Clinical Isolates

Efficacy of Vaporized Hydrogen Peroxide Combined with Silver Ions against Multidrug-Resistant Gram-Negative and Gram-Positive Clinical Isolates

Risk factors associated with hemodialysis catheter infection in a referral center

Population Pharmacokinetics of Vancomycin in Patients Receiving Hemodialysis in a Malian and a French Center and Simulation of the Optimal Loading Dose

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