A longitudinal study regarding conversion from mild memory impairment to dementia in a Japanese community

Ishikawa, Tomohisa; Ikeda, Manabu; Matsumoto, Naomi; Shigenobu, Kazue; Brayne, Carol; Tanabe, Hirotaka

doi:10.1002/gps.1437

Cited by 36 publications

(49 citation statements)

References 35 publications

(41 reference statements)

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“…In Germany, the Leipzing Longitudinal Study Of Aged (LEILA 75þ) reported the prevalence of MCI and modified-MCI which were 3.1 and 5.1%, respectively (Anja et al, 2003). In Japan, at baseline 104 subjects with mild memory impairment/not dementia (MMI/ND) were selected from 1162 community dwellers aged over 65 years and the prevalence was 8.95% (Ishikawa et al, 2006). In Canada, the most commonly used case definition of MCI yielded a population prevalence estimate of 1.03% from the Canadian Study of Health and Aging.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of mild cognitive impairment about elderly population in China: a meta-analysis

Nie

Liu

et al. 2010

Int. J. Geriat. Psychiatry

127

100

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Section: Discussionmentioning

confidence: 99%

The prevalence of mild cognitive impairment about elderly population in China: a meta-analysis

Nie

Liu

et al. 2010

Int. J. Geriat. Psychiatry

127

100

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“…Several groups reported findings in multiple publications, particularly those from large databases such as the CSHA. Where possible we excluded studies reporting subsamples and included only the main analysis (13,(32)(33)(34)(35). We included data from randomized trials but only using placebo data as this was considered more representative of the natural history of MCI.…”

Section: Excluded Studiesmentioning

confidence: 99%

Rate of progression of mild cognitive impairment to dementia – meta‐analysis of 41 robust inception cohort studies

Mitchell

Shiri-Feshki

2009

Acta Psychiatr Scand

1,350

932

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Objective: To quantify the risk of developing dementia in those with mild cognitive impairment (MCI).Method: Meta‐analysis of inception cohort studies.Results: Forty‐one robust cohort studies were identified. To avoid heterogeneity clinical studies, population studies and clinical trials were analysed separately. Using Mayo defined MCI at baseline and adjusting for sample size, the cumulative proportion who progressed to dementia, to Alzheimer’s disease (AD) and to vascular dementia (VaD) was 39.2%, 33.6% and 6.2%, respectively in specialist settings and 21.9%, 28.9% and 5.2%, respectively in population studies. The adjusted annual conversion rate (ACR) from Mayo defined MCI to dementia, AD and VaD was 9.6%, 8.1% and 1.9%, respectively in specialist clinical settings and 4.9%, 6.8% and 1.6% in community studies. Figures from non‐Mayo defined MCI and clinical trials are also reported.Conclusion: The ACR is approximately 5–10% and most people with MCI will not progress to dementia even after 10 years of follow‐up.

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“…Within the MCI group there are various subgroups, with the amnestic Mild Cognitive Impairment (aMCI) group characterized by a single memory disorder [2]. This group is at higher risk for converting to AD compared to healthy subjects and other MCI subtypes such as non-amnestic MCI [2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Altered Brain Activation During a Verbal Working Memory Task in Subjects with Amnestic Mild Cognitive Impairment

Bokde

Karmann

Born

et al. 2010

JAD

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In subjects with Mild Cognitive Impairment (MCI) memory disorders indicate a high risk for conversion to Alzheimer's disease (AD). The objective of this study was to delineate the differences in brain activation between amnestic MCI and age-matched healthy controls (HC) during a verbal working memory task. The verbal working memory task was a delay match to sample design. Brain activation was measured using functional magnetic resonance imaging. There were 8 subjects in each group and were matched for performance. The task was analyzed as an event-related design. Group differences were calculated using Analysis of Covariance (ANCOVA) with statistical significance at p < 0.05 corrected. Both groups activated a wide network in the posterior and frontal areas of the brain. There was higher activation in the parietal and frontal lobes in the MCI compared to the HC during the maintenance phase. There were no areas in the HC that activated higher than the MCI subjects. Response time in the task in the HC group was correlated to the left hippocampus during encoding phase and to the parietal and frontal areas during the recall phase. In the MCI group there was strong correlation to the inferior and middle temporal gyrii during encoding, the middle frontal gyrus during the maintenance phase, and hippocampus during recall phase. The activation differences between groups may be compensatory mechanisms within the MCI group for the effects of the putative AD neuropathology. This has been the first study that has examined verbal working memory in MCI.

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A longitudinal study regarding conversion from mild memory impairment to dementia in a Japanese community

Cited by 36 publications

References 35 publications

The prevalence of mild cognitive impairment about elderly population in China: a meta-analysis

The prevalence of mild cognitive impairment about elderly population in China: a meta-analysis

Rate of progression of mild cognitive impairment to dementia – meta‐analysis of 41 robust inception cohort studies

Altered Brain Activation During a Verbal Working Memory Task in Subjects with Amnestic Mild Cognitive Impairment

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