Altered Brain Activation During a Verbal Working Memory Task in Subjects with Amnestic Mild Cognitive Impairment

Bokde, Arun L.W.; Karmann, Michaela; Born, Christine; Teipel, Stefan J.; Omerovic, Muamer; Ewers, Michael; Frodl, Thomas; Meisenzahl, Eva; Reiser, Maximilian; Möller, Hans‐Jürgen; Hampel, Harald

doi:10.3233/jad-2010-091054

Cited by 88 publications

(61 citation statements)

References 76 publications

(97 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lesion studies on humans also showed that patients with medial temporal lobe damages had WM impairment (Ezzyat and Olson, 2008;Olson et al, 2006a,b). Functional MRI studies confirmed that the hippocampus was recruited for WM processing (Davachi and Wagner, 2002;Faraco et al, 2010;Karlsgodt et al, 2005;Toepper et al, 2010), and that hippocampal activation was significantly correlated with WM performance (Berent-Spillson et al, 2010;McGettigan et al, 2011) and/or WM response time (Bokde et al, 2010). Finally, a neural network study reported that the hippocampus was included in a network underlying the maintenance of WM (Gazzaley et al, 2004), suggesting a functional contribution of the hippocampus to WM.…”

Section: Introductionmentioning

confidence: 75%

The NTSR1 gene modulates the association between hippocampal structure and working memory performance

Jin¹,

Lei²,

Wang³

et al. 2013

NeuroImage

View full text Add to dashboard Cite

The genetic and neural basis of working memory (WM) has been extensively studied. Many dopamine (DA) related genes, including the NTSR1 gene (a DA modulator gene), have been reported to be associated with WM performance. The NTSR1 protein is predominantly expressed in the cerebral cortex and the hippocampus, the latter of which is closely involved in WM processing based on both lesion and fMRI studies. Thus far, however, no study has examined the joint effects of NTSR1 gene polymorphism and hippocampal morphology on WM performance. Participants of the current study were 330 healthy Chinese college students. WM performance was measured with a 2-back WM paradigm. Structural MRI data were acquired and then analyzed using an automated procedure with atlas-based FreeSurfer segmentation software (v 4.5.0) package. Linear regression analyses were conducted with a NTSR1 C/T polymorphism which was previously reported to be associated with WM (rs4334545), hippocampal volume, and their interaction as predictors of WM performance, with gender and intracranial volume (ICV) as covariates. Results showed a significant interaction between NTSR1 genotype and hippocampal volume (p b .05 for both the left and right hippocampi). Further analysis showed that the correlation between hippocampal volume and WM scores was significant for carriers of the NTSR1 T-allele (p b .05 for both hippocampi), but not for CC homozygotes. These results indicate that the association between hippocampal structure and WM performance was modulated by variation in the NTSR1 gene, and suggest that further studies of brain-behavior associations should take genetic background information into account.

show abstract

Section: Introductionmentioning

confidence: 75%

The NTSR1 gene modulates the association between hippocampal structure and working memory performance

Jin¹,

Lei²,

Wang³

et al. 2013

NeuroImage

View full text Add to dashboard Cite

show abstract

“…These findings indicate that with increasing task difficulty, additional frontal brain regions might have been recruited to play compensatory roles to complete the harder task. In general, the MFG plays a key role in maintaining information and supporting executive function during WM (33), and the SFG is recruited during object location in WM (34). In particular, results from a previous report indicated that gray matter density loss in the bilateral medial frontal gyrus and SFG of type 1 diabetic patients is significantly related to the severity of retinopathy, a common diabetes complication (35).…”

Section: Discussionmentioning

confidence: 97%

Altered Brain Activation Patterns Under Different Working Memory Loads in Patients With Type 2 Diabetes

et al. 2014

View full text Add to dashboard Cite

OBJECTIVEType 2 diabetes mellitus (T2DM) has important effects on cognition and the risk for Alzheimer disease (AD). Working memory (WM) is a susceptible cognitive domain of mild cognitive impairment and AD. Thus, the identification of brain activation patterns under different WM loads can potentially enhance our understanding of the mechanisms underlying cognitive dysfunction in T2DM. RESEARCH DESIGN AND METHODSThe current study assessed the effects of T2DM on cognitive performance and explored the related neuronal damage through a visual n-back task and functional magnetic resonance imaging. RESULTSWe found that patients with T2DM exhibited worse executive and memory abilities than control subjects. Furthermore, the patterns of brain activation changed under different WM loads in the T2DM patients, who exhibited reduced activation in the left inferior frontal gyrus under low loads and reduced activation in the left middle frontal gyrus and superior frontal gyrus (SFG) under high loads. Thus, more regions of diminished activation were seen in the frontal cortex with increasing task difficulty. Furthermore, we found that lower SFG activation was associated with worse cognitive function. CONCLUSIONSThe findings demonstrate deficient WM in patients with T2DM and the relation between cognitive function and degree of neuronal activity and their relevance to AD risk. Further longitudinal studies are needed to replicate these results and to evaluate the clinical value of brain imaging methods in the prediction of disease progress in these patients.

show abstract

“…Speech recognition in noise was generally worse in both elderly groups compared with young individuals. The low tolerance of noise during speech recognition is a common finding in subjects with age-related hearing loss, and the cause may be related to defects of central auditory processing [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] . As shown by our data, while normal young subjects do benefit from temporal fluctuation of ICRA noise and yet more consistently from the masking produced by continuous discourse, elderly subjects seem less capable of taking advantage of the masking envelope discontinuities, and this was much more evident in MCI subjects.…”

Section: Discussionmentioning

confidence: 99%

Speech Audiometry Tests in Noise Are Impaired in Older Patients with Mild Cognitive Impairment: A Pilot Study

Aimoni¹,

Prosser²,

Ciorba³

et al. 2015

Int Adv Otol

View full text Add to dashboard Cite

OBJECTIVE:Mild cognitive impairment (MCI) is a frequent condition in the older population; its early diagnosis might be particularly important for the prevention of dementia onset. In particular, the aim of this study is to evaluate whether speech recognition in noise might be impaired in older patients with MCI compared with normal older individuals. MATERIALS and METHODS:On the whole, 48 subjects were enrolled into the present study: 16 older patients with MCI, 16 older subjects without cognitive impairment (controls), and 16 normally hearing young individuals. All subjects underwent speech audiometry in noise in order to evaluate the effect of different types of masking: two kinds of energetic masking, stationary and fluctuating noise, and a kind of typical informative masking, consisting of continuous discourse. RESULTS:The signal-to-noise ratio (S/N), expressed in dB, needed for speech reception threshold (SRT) in noise was worse in older patients affected by MCI, compared with older controls. The presence of masking likely affected the performance of both elderly controls and MCI patients; however, elderly controls had better performance with informative masking (CoDi) than MCI patients. CONCLUSION:Speech audiometry tests in noise are impaired in MCI older patients, and this could indicate a particular decline in functions associated with selective attention in these individuals. If confirmed in a larger sample of patients, these simple tests might contribute to the early identification of MCI patients.

show abstract

Altered Brain Activation During a Verbal Working Memory Task in Subjects with Amnestic Mild Cognitive Impairment

Cited by 88 publications

References 76 publications

The NTSR1 gene modulates the association between hippocampal structure and working memory performance

The NTSR1 gene modulates the association between hippocampal structure and working memory performance

Altered Brain Activation Patterns Under Different Working Memory Loads in Patients With Type 2 Diabetes

Speech Audiometry Tests in Noise Are Impaired in Older Patients with Mild Cognitive Impairment: A Pilot Study

Contact Info

Product

Resources

About