A Longitudinal Study of Risk Factors for Incident Albuminuria in Diabetic American Indians: The Strong Heart Study

Xu, Jiaqiong; Lee, Elisa T.; Devereux, Richard B.; Umans, Jason G.; Bella, Jonathan N.; Shara, Nawar; Yeh, Jeunliang; Fabsitz, Richard R.; Howard, Barbara V.

doi:10.1053/j.ajkd.2007.11.010

Cited by 34 publications

(21 citation statements)

References 40 publications

(49 reference statements)

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“…This may reflect confounding by indication, given the use of these drugs to control albuminuria or hypertension, especially among patients with diabetes [24]. In contrast to other studies [25], a high HDL was found to be associated with a lower risk for albuminuria in our sample, which included those with and without diabetes.…”

Section: Discussioncontrasting

confidence: 69%

Albuminuria among Alaska Natives – Findings from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study

et al. 2010

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Background: The prevalence and associated risk factors for albuminuria and low-grade albuminuria in Alaska Natives is not known. Methods: Cross-sectional analysis of the Genetics of Coronary Artery Disease in Alaska Natives Study. We included 1,026 individuals, who represent 85% of the study participants for whom complete data were available. Risk factors examined were age, sex, education, diabetes, hypertension, obesity, lipids, C-reactive protein, angiotensin-converting enzyme inhibitor use, and smoking status. Urine albumin excretion was estimated by the albumin/creatinine ratio measured from a single random morning urine sample. Albuminuria was defined as an albumin/creatinine ratio of ≧30 mg/g. Low-grade albuminuria was defined as an albumin/creatinine ratio of 10 to <30 mg/g. Results: The mean age was 42 years and over half were female. Diabetes prevalence was low at 3% and the prevalence of hypertension was 20%. The prevalence of albuminuria was 6%; the prevalence of low-grade albuminuria was 12%. Individuals with diabetes or hypertension were 3 times more likely to have albuminuria than those without these conditions [odd ratios: diabetes 3.0 (1.2–7.9) and hypertension 3.0 (1.2–7.3)]. Conclusions: The burden of albuminuria is low. Comprehensive programs and policies are important given the rise in diabetes and hypertension among Alaska Natives.

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Section: Discussioncontrasting

confidence: 69%

Albuminuria among Alaska Natives – Findings from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study

et al. 2010

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“…These results suggest that high-normal DBP alone or in combination with metabolic disorders could initiate glomerular damage, leading to future microalbuminuria. Our data are consistent with the previous studies showing that baseline level of urinary albumin excretion is a strong predictor for future microalbuminuria in hypertensive, diabetic, and general population [11,18,19]. The mechanism of the link with slightly increased baseline urinary albumin excretion and incidence of microalbuminuria has never been clarified.…”

Section: Discussionsupporting

confidence: 89%

High-normal diastolic blood pressure is a risk for development of microalbuminuria in the general population

Konno

Hozawa

Miura

et al. 2013

Journal of Hypertension

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“…We found an association between mean follow-up HDL-C level and new-onset microalbuminuria. Similarly, Xu et al 29 reported low HDL-C level to be a predictor of incidental albuminuria in a longitudinal study.…”

Section: Commentmentioning

confidence: 83%

Prevention of Diabetic Nephropathy by Tight Target Control in an Asian Population With Type 2 Diabetes Mellitus

Chang²,

Chen³

et al. 2010

Arch Intern Med

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A Longitudinal Study of Risk Factors for Incident Albuminuria in Diabetic American Indians: The Strong Heart Study

Abstract: Background-There have been no studies that employ longitudinal data with more than two measurements and use methods of longitudinal data analysis to identify risk factors for incident albuminuria over time more effectively.

Cited by 34 publications

References 40 publications

Albuminuria among Alaska Natives – Findings from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study

Albuminuria among Alaska Natives – Findings from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study

High-normal diastolic blood pressure is a risk for development of microalbuminuria in the general population

Prevention of Diabetic Nephropathy by Tight Target Control in an Asian Population With Type 2 Diabetes Mellitus

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