A longitudinal study of red cell enzymes in infants of low birth weight

Herz, Fritz; Kaplan, Ervin; Scheye, Elsie S.

doi:10.1007/bf00439011

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…The lack of significant association between the mode of delivery of the newborns and G6PD deficiency in the present study is in line with those reported from Fars, Iran [40] and Egypt [41], while the lack of significant association of G6PD deficiency among newborns and prematurity is consistent with findings from Fars and Isfahan in Iran [40,42] and India [43]. Some studies suggest that premature infants can even have a higher G6PD activity compared to near term infants, and prematurity does not interfere with the diagnosis of G6PD deficiency [44,45]. On the other hand, the lack of significant association between the low birth weight (LBW) of newborns and G6PD deficiency in the present study could be partly attributed to the high prevalence of LBW among Yemeni neonates, which has been aggravated by the humanitarian crisis as a result of the ongoing war.…”

Section: Tablessupporting

confidence: 92%

“…In 2012, the prevalence of LBW was reported among about one-third of infants [46], and the situation is even worse at present. In a longitudinal study, Herz et al [44] found that LBW infants and prematurely delivered infants have a higher G6PD activity than normal ones. The lack of association between G6PD deficiency and LBW was also reported from Iran [29] and India [43].…”

Section: Tablesmentioning

confidence: 98%

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Glucose-6-Phosphate Dehydrogenase Deficiency among Newborns in Sana’a City, Yemen

Nassar

Hudna

Alhaj

et al. 2020

Zagazig University Medical Journal

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Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inborn enzymatic defect in the world. Determining the prevalence of G6PD deficiency is an essential step towards evaluating its impact on the health of a population. Therefore, this study aimed to determine the prevalence and factors associated with G6PD deficiency among newborns in Sana'a city, Yemen. Subjects and methods: This cross-sectional study included 397 newborns from eight public and private hospitals in Sana'a city in the period from January to March 2020. Data about gender and the factors possibly associated with G6PD deficiency were collected using a pre-designed questionnaire. G6PD deficiency was qualitatively detected in fresh blood using rapid diagnostic tests (RDTs). Data were analyzed using SPSS software, and differences were considered statistically significant at p-value <0.05. Results: Of 397 screened newborns (217 males and 180 females), 19 newborns (14 male and 5 female newborns) were G6PD-deficient, with an overall prevalence of 4.8% and a male: female ratio of 2.8:1. G6PD deficiency was significantly associated with consanguinity. However, it was not significantly associated with the gender, mode of delivery, gestational age or birth weight of the newborns. Conclusions: G6PD deficiency is prevalent among as low as approximately 5.0% of newborns in the hospitals of Sana'a city. It is almost comparable to those reported from other countries in the region. It is more prevalent among males than females, with no statistically significant difference. G6PD deficiency was not associated with the gender, mode of delivery, gestational age and birth weight of the newborns.

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Section: Tablessupporting

confidence: 92%

Section: Tablesmentioning

confidence: 98%

Glucose-6-Phosphate Dehydrogenase Deficiency among Newborns in Sana’a City, Yemen

Nassar

Hudna

Alhaj

et al. 2020

Zagazig University Medical Journal

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“…Our results on G6PD levels of full-term and preterm infants were comparable to those published on Caucasian subjects [8,16,22,23] . In a study of Taiwanese infants, Lee and Chou [8] also reported that the G6PD activity of preterm infants was higher than that of full-term infants.…”

Section: Discussionsupporting

confidence: 78%

Oxidative Challenge and Glucose-6-Phosphate Dehydrogenase Activity of Preterm and Term Neonatal Red Blood Cells

Wong

et al. 2009

Neonatology

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Background: Recent studies suggest that a low antioxidant level in preterm infants may predispose them to increased oxidative stress and results in hyperbilirubinemia, whereas glucose-6-phosphate dehydrogenase (G6PD) activity was found to be higher in preterm infants than in term infants. Objectives: To evaluate (1) the oxidative effect of α-naphthol on preterm and term red blood cells, and (2) the relationship between G6PD activity and the gestational age of these infants. Methods: G6PD activities were determined in preterm and term infants by a standard diagnostic method. Whole blood samples were incubated with α-naphthol for 2 h and their pre- and post-challenged reduced glutathione (GSH) levels were quantified. Results: The mean G6PD activity in preterm infants (n = 113; 13.52 ± 0.19 U/g Hb; gestational age 30.67 ± 0.28 weeks) was significantly higher than that in term infants (n = 100; 12.36 ± 0.16 U/g Hb; gestational age 39.82 ± 0.14 weeks; p < 0.001). A significantly negative correlation was demonstrated between gestational age and G6PD activity (r = –0.34, p < 0.001). GSH levels of preterm and term subjects were similar at baseline, but were significantly decreased upon challenge with α-naphthol (p < 0.001). The percentage reduction in GSH levels was similar in the various gestational age groups. Conclusions: Our data show that G6PD activities had a negative correlation with gestational age of G6PD-normal infants. The similar response of preterm and term erythrocytes to an α-naphthol challenge indicates the manifestation of an active anti-oxidative pathway mediated by cellular GSH.

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“…[8][9][10][11] A few studies have suggested that this trend may extend to premature neonates. [12][13][14][15] On the basis of these findings, we hypothesised that premature infants would have even higher G6PD activity than term infants. Overall, our hypothesis was correct: G6PD activity in the pooled group of premature infants was significantly higher than in the group of term neonates.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14][15] We therefore hypothesised that premature infants would have even higher G6PD activity than term neonates, and asked whether this increase would influence the ability to diagnose the deficiency state. In this study, we determined, quantitatively, normal values for red blood cell G6PD activity in male premature neonates and compared these values with those of healthy term and near term male infants.…”

mentioning

confidence: 99%

Glucose-6-phosphate dehydrogenase activity in male premature and term neonates

Mesner

Hammerman²,

Goldschmidt³

et al. 2004

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Background: Glucose-6-phosphate dehydrogenase (G6PD) activity is higher in term neonates than in adults. Some studies have suggested that activity may be even higher in preterm infants. Objectives: To determine if G6PD activity is higher in preterm than term neonates, and whether higher activity would interfere with diagnosis of G6PD deficiency in premature infants. Methods: G6PD activity was determined in the first 48 hours after delivery in male premature, term, and near term infants. G6PD deficient neonates were separated, and the remaining premature infants compared with healthy, male, G6PD normal, near term and term neonates. Results: Ninety four premature infants (mean (SD) gestational age 31.9 (3.8) weeks (range 23-36)) were studied. In four, G6PD activity was 0.8-1.8 U/g haemoglobin (Hb), which is clearly in the deficient range with no overlap into the normal range. G6PD activity in the remaining premature infants was significantly higher than in 24 near term and term neonates (gestational age > 37 weeks) (14.2 (4.6) v 12.0 (3.8) U/g Hb). Further analysis showed that significance was limited to those born between 29 and 32 weeks gestation, in which group G6PD activity was significantly higher than in those born before 29 weeks gestation, at 33-36 weeks gestation, and > 37 weeks gestation. Conclusions: G6PD activity is higher in premature infants born between 29 and 32 weeks gestation than in term neonates. This did not interfere with diagnosis of G6PD deficiency.

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A longitudinal study of red cell enzymes in infants of low birth weight

Cited by 6 publications

References 12 publications

Glucose-6-Phosphate Dehydrogenase Deficiency among Newborns in Sana’a City, Yemen

Glucose-6-Phosphate Dehydrogenase Deficiency among Newborns in Sana’a City, Yemen

Oxidative Challenge and Glucose-6-Phosphate Dehydrogenase Activity of Preterm and Term Neonatal Red Blood Cells

Glucose-6-phosphate dehydrogenase activity in male premature and term neonates

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