A Long Term Study of the Variation of Serum Cholesterol in Man 1

Sustained Hyperlipemia Induced in Rabbits by Means of Intravenously Injected Surface-Active Agents

“…In each animal there was a progressive increase in blood cholesterol and phospholipid content, which in some animals exceeded 2,000 rag./100 cc. 4 In still other experiments Triton A20 was injected intravenously into mice and guinea pigs; the serum of every animal so treated became milky and manifested elevations of blood lipids quite comparable to those observed in rabbits.…”

Dietary Fats and the Diurnal Serum Triglyceride Levels in Man

“…Recently, Albrink and Man (4) have reported a better correlation between fasting serum triglyceride concentration and the incidence of clinical atherosclerosis than that of serum cholesterol levels. It has been shown that both fat and carbohydrate ingestion can cause a rapid and profound change in the concentration of this labile serum lipid fraction (5)(6)(7)(8)(9)(10)(11). Consequently, adequate information of the dietary effect upon the serum triglyceride level in a given patient can only be obtained by studying the changing concentrations of the lipid in his blood throughout the 24 hour period.…”

“…The works of Cunningham and Peters (5), Man and Gildea (6), Elkes, Frazer and Stewart (7), Brun (8), Turner and Steiner (9) and Havel (10,11) clearly demonstrated that variations in both the fat and carbohydrate contents of each meal consistently produced rapid and marked changes in the triglyceride concentration in the human serum, while at the same time, they caused little or no change in the serum cholesterol concentration.…”

Idiopathic Hypercholesterolemia: Demonstration of an Impaired Feedback Control of Cholesterol Synthesis <i>in vivo</i>

“…It has been suggested that the plasma cholesterol level is regulated by an efficient homeostatic mechanism. [1][2][3][4][5] This homeostatic control of the cholesterol concentration in the body has been extensively studied with animal experimenta tions and has been shown to possess the characteristics of a negative feedback control system. [6][7][8][9][10][11] In a recent in vitro study,12 it has been demonstrated that human adults possess a hepatic feedback mechanism for regulating the synthesis of cholesterol.…”