Sustained Hyperlipemia Induced in Rabbits by Means of Intravenously Injected Surface-Active Agents

Kellner, Aaron; Correll, James W.; Ladd, Anthony T.

doi:10.1084/jem.93.4.373

Cited by 209 publications

(69 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is of interest to note that with batches of triton obtained from the manufacturer prior to 1953 there regularly occurred a generalized convulsion following intravenous injection, similar to that previously described in rabbits (1). Batches obtained after 1953, however, did not produce convulsions.…”

Section: Increased Serum Clmlesterol and Phospholipides In Mice Givensupporting

confidence: 55%

“…The increase in serum phospholipides generally paralled that of the cholesterol, though in several instances the cholesterol level was appreciably higher than the corresponding phosphoUpide level. The fact that the serum in all cases was milky at the height of Upemia suggests that, as in the case of rabbits given triton, there was also a notable increase in serum neutral fat (1,6), though this group of lipides was not measured in these experiments.…”

Section: Increased Serum Clmlesterol and Phospholipides In Mice Givenmentioning

confidence: 65%

See 1 more Smart Citation

The Pathogenesis of Hyperlipemia Induced by Means of Surface-Active Agents

Hirsch

Kellner

1956

The Journal of Experimental Medicine

Self Cite

View full text Add to dashboard Cite

Mice rendered hyperlipemic by means of intravenous or subcutaneous injections of triton WR 1339 were found to have an increase in the total amount of cholesterol in their bodies. This observation indicates that the injected surface-active agent affects the metabolism of cholesterol and brings about hyperlipemia by augmenting the synthesis of lipides, or by interfering with their degradation or excretion, or by some combination of these factors. The implications of the findings for the pathogenesis of the hyperlipemia induced by triton are discussed further in the accompanying paper (16).

show abstract

Section: Increased Serum Clmlesterol and Phospholipides In Mice Givensupporting

confidence: 55%

Section: Increased Serum Clmlesterol and Phospholipides In Mice Givenmentioning

confidence: 65%

The Pathogenesis of Hyperlipemia Induced by Means of Surface-Active Agents

Hirsch

Kellner

1956

The Journal of Experimental Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Triton WR-1339 has been widely used to block clearance of triglyceride-rich lipoproteins to induce acute hyperlipidaemia in several animals [25]. This model is widely used for a number of different aims [26] and, in particular, in rats it has been used for screening natural or chemical hypolipidaemic drugs because it is convenient in terms of length of treatment period and handling.…”

Section: Discussionmentioning

confidence: 99%

Anti-hyperlipidemic Activity of Thieno - [2, 3-d] - Pyrimidin-4-(3H)-ones

Rangappa¹,

Venkataranganna²,

Saravanan³

2011

Macedonian Journal of Medical Sciences

View full text Add to dashboard Cite

Aim: The present study was aimed to evaluate some newly synthesized thieno -[2, 3-d] -pyrimidin-4-(3H)-ones namely SR-C1 to SR-C12 for their anti-hyperlipidemic activity. Materials and Methods:Anti-hyperlipidemic activity was evaluated using Triton 1339-induced hyperlipedemia in rats as an experimental model. Plasma triglycerides, total cholesterol, HDL-C, LDL-C, atherogenic index (AI) and LDL-C/HDL-C ratio were determined to assess the anti-hyperlipidemic activity.Results: SR-C1,SR-C4, SR-C5, SR-C6, SR-C7, SR-C11 and SR-C12 have shown significant antihyperlipidemic activity by decreasing the total cholesterol and triglyceride, LDL-cholesterol, atherogenic index and LDL/HDL ratio (p < 0.001) and by increasing the HDL-Cholesterol (p < 0.001). Conclusion:The findings of the present study clearly demonstrates that methyl, methoxy, chloro, dimethylamino, dimethoxy and trimethoxy functional groups possess cholesterol-suppressive capacities and has an ability to attenuate the accelerated development of atherosclerosis in hypercholesterolemic models. However, hydroxyl and nitro derivatives did not show any hypolipidemic activity.

show abstract

“…4-Arsonophenylazoprotein produces a high and prolonged hyperlipemia, 4-sulfono-and 4-carboxyphenlazoproteins produce an initial raising and later lowering of blood fat levels. The hyperlipemia consists almost entirely of triglyceride; non-triglyceride lipids are increased relatively little by any of the azoproteins, in this resembling the changes induced in animals treated by Kellner et al with tween 80 and tritons (7).…”

Section: Tke Effects Of 4-sulfono-and 4-carboxypkenylaz~proteins On Tmentioning

confidence: 51%

Effects of Acidic Azoproteins on Plasma Triglyceride Levels and on the Heparin-Activated Clearing System

Broome

1964

The Journal of Experimental Medicine

View full text Add to dashboard Cite

Heparin injected into animals of several species activates a powerful lipid clearing system in the blood plasma, as was first shown by Hahn (1). The factor responsible for clearing is recognized to be a lipase (2) but despite considerable work, recently reviewed by Robinson and French (3,4), its precise role in the physiological processes of fat transport remains uncertain.The principal evidence suggesting the functional importance of the clearing system is the finding that certain substances which raise the level of blood triglyceride in vivo also inhibit the cleating system in vitro. Brown (5) and Bragdon and Havel (6) showed that protamine and toluidine blue, long recognized as antagonists of the anticoagulant action of heparin, produce raised blood triglyeeride levels after injection into rats. Similarly, 2 non-ionic surface active agents, triton A 20 and tween 80 whose hyperfipemic effect was described by Kellner et al. (7), have also been shown to inhibit this system (8). Recently Rudman and Seidman showed that pituitary extracts when injected into rabbits caused delayed hyperlipemia (9). Kellner et al. showed that the extracts alone produced no effect on the heparin-activated clearing system in vitro, but plasma from animals made hyperlipemic by them was strongly inhibitory (10).The purpose of the present publication is to add to the short list of agents producing hyperlipemia members of a distinctly different group of chemical substances, the acidic azoproteins. The effects produced depend entirely on the particular acidic group present in the azoprotein. For while the 4-arsonophenyl causes a marked and prolonged hyperlipemia, 2 other groups, the 4-sulfonophenyl and the 4-carboxyphenyl, produce more complex results consisting of an initial raising and later lowering of the levels of blood triglyceride. It is further intended to show that these end results can be related to the effects of the partitular szoprotein on the lipase clearing system, thus providing further evidence that this system has a significant role in regulating blood triglyceride levels.

show abstract

Sustained Hyperlipemia Induced in Rabbits by Means of Intravenously Injected Surface-Active Agents

Cited by 209 publications

References 18 publications

The Pathogenesis of Hyperlipemia Induced by Means of Surface-Active Agents

The Pathogenesis of Hyperlipemia Induced by Means of Surface-Active Agents

Anti-hyperlipidemic Activity of Thieno - [2, 3-d] - Pyrimidin-4-(3H)-ones

Effects of Acidic Azoproteins on Plasma Triglyceride Levels and on the Heparin-Activated Clearing System

Contact Info

Product

Resources

About