A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices

Verza, Beatriz S.; Beucken, Jeroen J.J.P. van den; Brandt, João Victor; Jafelicci, Miguel; Barão, Valentim Adelino Ricardo; Piazza, Rodolfo Debone; Tagit, Oya; Spolidório, Denise Madalena Palomari; Vergani, Carlos Eduardo; Ávila, Érica Dorigatti de

doi:10.1016/j.carbpol.2020.117604

Cited by 31 publications

(19 citation statements)

References 58 publications

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“…In most cases, the obtained release profiles indicate an initial fast release, followed by a slower release, and finally a plateau, all ranging from a few hours to a few months. It can be seen that some coating formulations prepared via electrospinning [ 87 , 108 ], electrophoretic deposition [ 41 , 114 ], dip coating [ 40 ], LbL [ 102 ], and anodization [ 214 ] may provide a drug release for more than a month.…”

Section: Controlled Releasementioning

confidence: 99%

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Kravanja

Finšgar

2021

Biomedicines

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The development of bioactive coatings for orthopedic implants has been of great interest in recent years in order to achieve both early- and long-term osseointegration. Numerous bioactive materials have been investigated for this purpose, along with loading coatings with therapeutic agents (active compounds) that are released into the surrounding media in a controlled manner after surgery. This review initially focuses on the importance and usefulness of characterization techniques for bioactive coatings, allowing the detailed evaluation of coating properties and further improvements. Various advanced analytical techniques that have been used to characterize the structure, interactions, and morphology of the designed bioactive coatings are comprehensively described by means of time-of-flight secondary ion mass spectrometry (ToF-SIMS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), 3D tomography, quartz crystal microbalance (QCM), coating adhesion, and contact angle (CA) measurements. Secondly, the design of controlled-release systems, the determination of drug release kinetics, and recent advances in drug release from bioactive coatings are addressed as the evaluation thereof is crucial for improving the synthesis parameters in designing optimal bioactive coatings.

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Section: Controlled Releasementioning

confidence: 99%

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Kravanja

Finšgar

2021

Biomedicines

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“…Biomaterials are also used as a structure to retain antimicrobial drugs and release them over time into a specific target. Herein, several potential strategies are available to modify the dental implant surfaces and their components through the coating development using physical and chemical techniques. , Within physical modification possibilities, the layer-by-layer (LbL) assembly method has been extensively studied to couple antimicrobial drugs into a noncytotoxic structure. ,, Basically, the LbL system is a technique to create thin films through a simple alternating adsorption of complementary multivalent species on a substrate via electrostatic interactions. This system allows effective incorporation of one or more drugs in high concentrations within the multilayer film independent of the size or shape of the substrate based on electrochemical potential .…”

Section: Discussionmentioning

confidence: 99%

“…The complexities of the LbL system make it difficult to build a product. The electrostatic interactions among polyelectrolytes used for LbL assembly, for example, and between them and the substrate must be strong enough to reach the coating purpose in terms of disease prevention/treatment. ,,, Similarly, the affinity between carrier molecules and drug moieties is crucial for controlling drug loading and release. Antimicrobial coatings must disclose a stimuli-responsive property to achieve release of meaningful doses for a determined and established period of time.…”

Section: Discussionmentioning

confidence: 99%

“…66,67 Within physical modification possibilities, the layer-by-layer (LbL) assembly method has been extensively studied to couple antimicrobial drugs into a noncytotoxic structure. 64,68,69 Basically, the LbL system is a technique to create thin films through a simple alternating adsorption of complementary multivalent species on a substrate via electrostatic interactions. This system allows effective incorporation of one or more drugs in high concentrations within the multilayer film independent of the size or shape of the substrate based on electrochemical potential.…”

Section: Experimental Antimicrobial Surfaces For Managing Peri-implan...mentioning

confidence: 99%

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Race for Applicable Antimicrobial Dental Implant Surfaces to Fight Biofilm-Related Disease: Advancing in Laboratorial Studies vs Stagnation in Clinical Application

Ávila

Nagay

Pereira

et al. 2022

ACS Biomater. Sci. Eng.

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Across years, potential strategies to fight periimplantitis have been notoriously explored through the antimicrobial coating implant surfaces capable of interfering with the bacterial adhesion process. However, although experimental studies have significantly advanced, no product has been marketed so far. For science to reach the society, the commercialization of research outcomes is necessary to provide real advancement in the biomedical field. Therefore, the aim of this study was to investigate the challenges involved in the development of antimicrobial dental implant surfaces to fight peri-implantitis, through a systematic search. Research articles reporting antimicrobial dental implant surfaces were identified by searching PubMed, Scopus, Web of Science, The Cochrane Library, Embase, and System of Information on Grey Literature in Europe, between 2008 and 2020. A total of 1778 studies were included for quality assessment and the review. An impressive number of 1655 articles (93,1%) comprised in vitro studies, whereas 123 articles refer to in vivo investigations. From those 123, 102 refer to animal studies and only 21 articles were published on the clinical performance of antibacterial dental implant surfaces. The purpose of animal studies is to test how safe and effective new treatments are before they are tested in people. Therefore, the discrepancy between the number of published studies clearly reveals that preclinical investigations still come up against several challenges to overcome before moving forward to a clinical setting. Additionally, researchers need to recognize that the complex journey from lab to market requires more than a great idea and resources to develop a commercial invention; research teams must possess the skills necessary to commercialize an invention.

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“…With regards to responsive polymers, thermoresponsive polymers, such as poly [oligo (ethylene glycol) methacrylates] (POEGMA) are frequently used to manipulate cell adhesion (Nagase et al, 2009). In this sense, several methods and strategies to develop polymeric surfaces can be highlight: layer-by-layer (LbL) assembly (de Avila et al, 2019;Verza et al, 2021), lithographic surface modification techniques, electrospun fibers, spin coating, 3D bioprinting, self-assembled monolayers (SAMs) and polymer brush (Cai et al, 2020).…”

Section: Main Textmentioning

confidence: 99%

Implant surface features as key role on cell behavior

Molon¹,

Pereira²,

Ávila³

2022

Biocell

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It has been recognized that physical and chemical properties of biomaterial surfaces mediate the quality of extracellular matrix (ECM) that may affect cell behaviors. In nature, ECM is a heterogeneous three-dimensional superstructure formed by three major components, glycosaminoglycan, glycoconjugate, and protein, that anchors cellular compartments in tissues and regulates the function and the behavior of cells. Changes in the biointerface alter the quality of ECM and morphology through cell surface receptors, which, in turn, enable it to trigger specific cell signaling and different cellular responses. In fact, a number of strategies have been used to improve the functionality of surfaces and direct cell behavior through precisely designed environments. Herein, we aimed to discuss, through a science-based viewpoint, the biomaterial surface features on cell behavior and analyze the impact of cell physical modification on dental implant development.

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A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices

Cited by 31 publications

References 58 publications

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Race for Applicable Antimicrobial Dental Implant Surfaces to Fight Biofilm-Related Disease: Advancing in Laboratorial Studies vs Stagnation in Clinical Application

Implant surface features as key role on cell behavior

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