A Localizing Circumferential Compression Device Increases Survival after Coral Snake Envenomation to the Torso of an Animal Model

Hack, Jason B.; DeGuzman, Jocelyn M.; Brewer, Kori L.; Meggs, William J.; O’Rourke, Dorcas P.

doi:10.1016/j.jemermed.2010.04.027

Cited by 14 publications

(9 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Laboratory work with radiolabeled D. siamensis venom confirmed the delay in its systemic spread [ 144 ]. Consistent with the above, some authors have supported the use of pressure-immobilization for potently neurotoxic or coagulotoxic non-Australian snakes such as Daboia , Dispholidus , Echis , Thelotornis Dendroaspis , Micrurus and Naja [ 145 , 146 ].…”

Section: Issues and Controversies In Modern Medical Carementioning

confidence: 74%

Snakebite: When the Human Touch Becomes a Bad Touch

Fry

2018

Toxins

View full text Add to dashboard Cite

Many issues and complications in treating snakebite are a result of poor human social, economic and clinical intervention and management. As such, there is scope for significant improvements for reducing incidence and increasing patient outcomes. Snakes do not target humans as prey, but as our dwellings and farms expand ever farther and climate change increases snake activity periods, accidental encounters with snakes seeking water and prey increase drastically. Despite its long history, the snakebite crisis is neglected, ignored, underestimated and fundamentally misunderstood. Tens of thousands of lives are lost to snakebites each year and hundreds of thousands of people will survive with some form of permanent damage and reduced work capacity. These numbers are well recognized as being gross underestimations due to poor to non-existent record keeping in some of the most affected areas. These underestimations complicate achieving the proper recognition of snakebite’s socioeconomic impact and thus securing foreign aid to help alleviate this global crisis. Antivenoms are expensive and hospitals are few and far between, leaving people to seek help from traditional healers or use other forms of ineffective treatment. In some cases, cheaper, inappropriately manufactured antivenom from other regions is used despite no evidence for their efficacy, with often robust data demonstrating they are woefully ineffective in neutralizing many venoms for which they are marketed for. Inappropriate first-aid and treatments include cutting the wound, tourniquets, electrical shock, immersion in ice water, and use of ineffective herbal remedies by traditional healers. Even in the developed world, there are fundamental controversies including fasciotomy, pressure bandages, antivenom dosage, premedication such as adrenalin, and lack of antivenom for exotic snakebites in the pet trade. This review explores the myriad of human-origin factors that influence the trajectory of global snakebite causes and treatment failures and illustrate that snakebite is as much a sociological and economic problem as it is a medical one. Reducing the incidence and frequency of such controllable factors are therefore realistic targets to help alleviate the global snakebite burden as incremental improvements across several areas will have a strong cumulative effect.

show abstract

Section: Issues and Controversies In Modern Medical Carementioning

confidence: 74%

Snakebite: When the Human Touch Becomes a Bad Touch

Fry

2018

Toxins

View full text Add to dashboard Cite

show abstract

“…Micrurus fulvius fulvius venom even has strong hemorrhagic activity in mice although this has not been observed in dogs . The most clinically relevant toxic components of the venom are postsynaptic α‐neurotoxins . These are low molecular weight, basic polypeptides that block the nicotinic acetylcholine receptors of neuromuscular junctions and cause a curare‐like effect characterized by vasomotor instability, central nervous system depression, and muscle paralysis .…”

Section: Introductionmentioning

confidence: 99%

“…The most clinically relevant toxic components of the venom are postsynaptic α‐neurotoxins . These are low molecular weight, basic polypeptides that block the nicotinic acetylcholine receptors of neuromuscular junctions and cause a curare‐like effect characterized by vasomotor instability, central nervous system depression, and muscle paralysis . The phospholipases are myotoxic and cardiotoxic and can cause a decrease in cardiac and skeletal muscle contractility, swelling of individual muscle fibers, and hyaline degeneration .…”

Section: Introductionmentioning

confidence: 99%

“…Human coral snakebite victims should be immobilized, if possible, and immediately transported to a medical care facility. Based on experimental studies in animals, immediate treatment recommendations for people include a pressure‐immobilization bandage in order to delay absorption of the venom into the systemic circulation . Pressure‐immobilization with a 2‐inch wide elastic bandage and splints more than doubled average survival time in a porcine model .…”

Section: Introductionmentioning

confidence: 99%

“…Pressure‐immobilization with a 2‐inch wide elastic bandage and splints more than doubled average survival time in a porcine model . If the bite occurs in the torso, a localizing circumferential compression device should be applied since, in a porcine model, this device increased survival time and delayed the onset of envenomation from eastern coral snake venom . These porcine models have not been validated for dogs and cats nor would they be of any practical use in the small animal that is transported to the emergency facility by the pet owner.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A retrospective evaluation of coral snake envenomation in dogs and cats: 20 cases (1996–2011)

Pérez

Fox

Schaer

2012

J Vet Emergen Crit Care

View full text Add to dashboard Cite

Diagnosis of eastern coral snake envenomation is likely in the dog that has concomitant lower motor neuron neuropathy, bulbar palsy, and hemolysis. Early diagnosis is crucial as antivenom administration can reduce morbidity. Prognosis is considered good with 71% of the envenomated patients in this study surviving to discharge. Supportive care that may include ventilator assistance and antivenom administration are the mainstays of therapy.

show abstract

North American Coral Snake Envenomation

Anwar¹,

Bernstein²

2017

Toxinology

View full text Add to dashboard Cite

A Localizing Circumferential Compression Device Increases Survival after Coral Snake Envenomation to the Torso of an Animal Model

Cited by 14 publications

References 23 publications

Snakebite: When the Human Touch Becomes a Bad Touch

Snakebite: When the Human Touch Becomes a Bad Touch

A retrospective evaluation of coral snake envenomation in dogs and cats: 20 cases (1996–2011)

North American Coral Snake Envenomation

Contact Info

Product

Resources

About