A linac-based stereotactic irradiation technique of uveal melanoma

Dieckmann, Karin; Bogner, Joachim; Georg, Dietmar; Zehetmayer, Martin; Kren, Gerhard; Pötter, Richard

doi:10.1016/s0167-8140(01)00413-3

Cited by 58 publications

(51 citation statements)

References 27 publications

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“…In the past decade, linear accelerator (LINAC) based stereotactic radiotherapy (SRT) of uveal melanoma has been investigated for its potential as an alternative option (25)(26)(27)(28)(29)(30)(31)(32)(33). A reliable eye fixation technique with online control to ensure successful irradiation of the tumor volume has been developed and investigated (26,34).…”

Section: Introductionmentioning

confidence: 99%

Local Tumor Control, Visual Acuity, and Survival After Hypofractionated Stereotactic Photon Radiotherapy of Choroidal Melanoma in 212 Patients Treated Between 1997 and 2007

Dunavoelgyi

Dieckmann

Gleiß

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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Section: Introductionmentioning

confidence: 99%

Local Tumor Control, Visual Acuity, and Survival After Hypofractionated Stereotactic Photon Radiotherapy of Choroidal Melanoma in 212 Patients Treated Between 1997 and 2007

Dunavoelgyi

Dieckmann

Gleiß

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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“…Results show the pupil's off-center deviation was less than 1 mm among 23 patients [9]. Using an external light source to "lock" the eyeball's direction is another approach [7].…”

Section: Discussionmentioning

confidence: 99%

“…Investigations on non-invasive approaches for radiosurgery in uveal melanoma treatment have usually been focused on eyeball stabilization [7,9,22,26]. One method proposed to mount a LED light source (or flashing light) and a mirror (or a camera) next to the patient.…”

Section: Introductionmentioning

confidence: 99%

A mechanical eyeball phantom for uveal melanoma radiosurgery by cyberknife

Chen

Hatoum

et al. 2014

J Radiat Oncol

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Objective A treatment option for uveal melanoma has been investigated using the Cyberknife system, due to its advantage of real-time image guidance during therapy. However, unpredictable eyeball movement imposes challenges to the state-ofart technology. As a solution, we derived a 2D/3D transformation algorithm that is based on the pupil's 2D coordinates captured by an optical tracking system to predict the tumor's 3D positions in real-time. In order to validate our developed algorithm and other methods, a mechanical phantom that can simulate the eyeball's movement is highly desirable. Methods We designed a mechanical phantom that consists of a camera module, an eyeball module with an embedded "tumor", an eyeball holder module, and an eyeball moving module. All materials are made with acrylic or nylon plastics with the exception of the linear motion stages and the camera. Results In the calibration procedure, the phantom is scanned using a CT scanner. By using the recorded pupil's coordinates and extracted tumor coordinates, the 2D/3D transformation model yields 0.39±0.09 mm root-sum-squared error for five calibration positions between the actual 3D coordinates and the predicted coordinates. In the validation procedure, the eyeball is rotated to 11 different positions through the mechanical phantom. The 2D/3D transformation model yields 0.58±0.27 mm root-sum-squared error for these positions between the Cyberknife-identified 3D coordinates and the predicted coordinates. The eyeball's position can be controlled within millimeter accuracy. Conclusion The designed mechanical phantom is suitable for validating image-guided radiosurgery methods. Further dynamic evaluations can confirm these methods for clinical applications.

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“…The patient race was Caucasian (n = 7918, 98 %), Hispanic (n = 105, 1 %), Asian (n = 44, < 1 %), or African American (n = 33, < 1 %). On the basis of the race (Caucasian, Hispanic, Asian, and African American), signifi cant differences were noted in the mean age at presentation (58, 48, 44, and 52 years; p < 0.001), distance of posterior tumor margin to foveola (5,5,6, and 4 mm; Pp < 0.001), distance of posterior tumor margin to optic disc (5,5,6, and 4 mm; p < 0.001), tumor base (11,12,12, and 13 mm; p < 0.001), tumor thickness (5.4, 7.1, 6.5, and 7.5 mm; p < 0.001), intraocular hemorrhage (10, 14, 11, and 24 %; p = 0.02), and rupture of Bruch's membrane (20,27,39, and 36 %; p = 0.001). On the basis of multivariate analysis, the rate of metastasis increased with an increasing age (p < 0.001), ciliary body location (p < 0.001), increasing tumor base (p < 0.001), increasing tumor thickness (p < 0.001), pigmented tumor (p = 0.001), subretinal fl uid (p = 0.001), intraocular hemorrhage (p = 0.045), and extraocular extension ( p= 0.036).…”

Section: B Amentioning

confidence: 99%

Is it sufficient to repeat LINEAR accelerator stereotactic radiosurgery in choroidal melanoma?

Furdová¹,

Horkovičová²,

Justusova³

et al. 2016

BLL

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OBJECTIVES: One day session LINAC based stereotactic radiosurgery (SRS) at LINAC accelerator is a method of "conservative" attitude to treat the intraocular malignant uveal melanoma. METHODS: We used model Clinac 600 C/D Varian (system Aria, planning system Corvus version 6.2 verifi cation IMRT OmniPro) with 6 MeV X by rigid immobilization of the eye to the Leibinger frame. The stereotactic treatment planning after fusion of CT and MRI was optimized according to the critical structures (lens, optic nerve, also lens and optic nerve at the contralateral side, chiasm). The fi rst plan was compared and the best plan was applied for therapy at C LINAC accelerator. The planned therapeutic dose was 35.0 Gy by 99 % of DVH (dose volume histogram). RESULTS: In our clinical study in the group of 125 patients with posterior uveal melanoma treated with SRS, in 2 patients (1.6 %) was repeated SRS indicated. Patient age of the whole group ranged from 25 to 81 years with a median of 54 TD was 35.0 Gy. In 2 patients after 5 year interval after stereotactic radiosurgery for uveal melanoma stage T1, the tumor volume increased to 50 % of the primary tumor volume and repeated SRS was necessary. CONCLUSION: To fi nd out the changes in melanoma characteristics after SRS in long term interval after irradiation is necessary to follow up the patient by an ophthalmologist regularly. One step LINAC based stereotactic radiosurgery with a single dose 35.0 Gy is one of treatment options to treat T1 to T3 stage posterior uveal melanoma and to preserve the eye globe. In some cases it is possible to repeat the SRS after more than 5 year interval (Fig. 8, Ref. 23). Text in PDF www.elis.sk.

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A linac-based stereotactic irradiation technique of uveal melanoma

Cited by 58 publications

References 27 publications

Local Tumor Control, Visual Acuity, and Survival After Hypofractionated Stereotactic Photon Radiotherapy of Choroidal Melanoma in 212 Patients Treated Between 1997 and 2007

Local Tumor Control, Visual Acuity, and Survival After Hypofractionated Stereotactic Photon Radiotherapy of Choroidal Melanoma in 212 Patients Treated Between 1997 and 2007

A mechanical eyeball phantom for uveal melanoma radiosurgery by cyberknife

Is it sufficient to repeat LINEAR accelerator stereotactic radiosurgery in choroidal melanoma?

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