Results suggest that CMM may correlate with BCVA at BSL, but has limited predictive value regarding recovery of visual function. Most interesting, ODR correlated with BCVA under therapy and was the only parameter that was pathognomic for nAMD in contrast to CSC in this study. ODR may reflect the status of the blood-retina barrier and may be used for pathophysiologic differentiation and prognostic purposes in exudative macular disease.
GA and FS changed inversely over time. In general, FS highly correlated with BCVA, while GA progression correlated with the central 3-mm FS regression, but not with BCVA. A threshold in GA and FS area could be determined for BCVA necessary for daily activity.
Purpose To compare 1-year functional and anatomic outcomes of intravitreal bevacizumab (IVB) and photodynamic therapy plus intravitreal triamcinolone (PDT þ IVTA) combination in patients with neovascular age-related macular degeneration (AMD). Methods In this prospective, randomised, controlled clinical trial, 28 patients were included. All patients were randomised 1 : 1 to 0.04 ml/1 mg of IVB or PDT plus same day 0.1 ml/4 mg IVTA (PDT þ IVTA). Follow-up examinations were performed in monthly intervals in IVB group and every 3 months in PDT þ IVTA group. Main outcomes were change in mean visual acuity (VA), mean central retinal thickness (CRT) and the mean number of treatments. Results At month 12, mean VA improved to a 1.5-line gain in IVB group, and lost three letters in PDT þ IVTA group (P ¼ 0.02). Mean CRT was reduced from 357 lm at baseline to 244 lm at month 12 in IVB group and from 326 lm to 254 lm, respectively, in PDT þ IVTA group (P ¼ 0.8). The mean number of treatments was 6.8 in the IVB group vs 1.9 in the PDT þ IVTA group. No significant local or systemic safety concerns were detected during follow-up time. Conclusions Patients treated with IVB showed a significant better VA outcome compared with the PDT þ IVTA group despite the fact that both modalities showed equal potency in reducing CRT during a 12-month period.
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