A large cluster of human infections of Streptococcus suis in Bali, Indonesia

Tarini, Ni Made Adi; Susilawathi, Ni Made; Sudewi, Anak Agung Raka; Soejitno, Andreas; Fatmawati, Ni Nengah Dwi; Mayura, I.P.B.; Lestari, Anak Agung Wiradewi; Suputra, G.; Subrata, I.K.; Astiti, C.I.S.D.; Besung, I Nengah Kerta; Mahardika, Gusti Ngurah

doi:10.1016/j.onehlt.2022.100394

Cited by 6 publications

(10 citation statements)

References 23 publications

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“…In pigs, S. suis is transmitted primarily via aerosol, and airborne transmission between pigs has been clearly demonstrated ( 33 ). Human S. suis infections were almost always related to pig handling, pig slaughtering, or pork consumption ( 34 ) and might account for the presence of the 3 human isolates and the majority of the swine isolates in lineage I. Interestingly, a human isolate from Guangdong and a porcine isolate from Guangdong shared only 9 SNPs, and this was indicative of clonal transmission between animals and humans. Notably, Guangdong human isolate SS18-6, isolated in 2019, and 05ZYH33 ( 35 ), which caused the second large-scale outbreak of S. suis infection in China, were both part of lineage I.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Resistance Patterns and Molecular Characterization of Streptococcus suis Isolates from Swine and Humans in China

Wang

Chu

et al. 2023

Microbiol Spectr

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Section: Discussionmentioning

confidence: 99%

Antibiotic Resistance Patterns and Molecular Characterization of Streptococcus suis Isolates from Swine and Humans in China

Wang

Chu

et al. 2023

Microbiol Spectr

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“…[ 12 ] A specific clinical manifestation in the early stage of S suis infection is absent, and patients with meningitis usually present with fever, myalgia, neck stiffness, headache, nausea, vomiting, dizziness, and other symptoms. [ 13 , 14 ] The classic meningitis triad is characterized by fever, headache, and an altered state of consciousness. [ 15 ] In our patient, the clinical manifestations of fever, generalized pain, headache, dizziness, vomiting, and altered consciousness were consistent with meningitis.…”

Section: Discussionmentioning

confidence: 99%

Meningitis and sepsis caused by Streptococcus suis in an elderly woman: A CARE-compliant case report

Li,

Hong

et al. 2023

Medicine

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Rationale: Streptococcus suis (S suis)-associated infections are uncommon but life-threatening diseases. The clinical manifestations vary from general symptoms of bacterial infection to fatal meningitis. The clinical manifestation and routine diagnostic testing is not specific enough to obtain well-time diagnosis. Patient concerns and diagnosis: We report a case of meningitis and sepsis caused by S suis infection. A 70-year-old woman presented to our emergency department with generalized pain. After hospital admission, her condition rapidly deteriorated to fever, intracranial hypertension, and disturbance of consciousness. Examination of the blood and cerebrospinal fluid with metagenomic next-generation sequencing and bacterial cultures revealed S suis infection. Interventions and outcomes: After anti-infection therapy with meropenem and vancomycin, the patient recovered and was discharged from the hospital with no residual effects. Lessons: Human infections with S suis are extremely rare. If clinicians encounter a patient with fever, disturbance of consciousness, and intracranial hypertension, especially those who have been exposed to raw pork, S suis infection should be considered. Metagenomic next-generation sequencing can be a useful adjunct for the rapid diagnosis of S suis infection and aid in the planning of clinical treatment. Meanwhile, public health awareness is necessary to limit the risk of S suis infection.

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“…International Journal of Veterinary Science 12(3): 443-449. https://doi.org/10.47278/journal.ijvs/2022.214 during August 2014 and December 2017 (Susilawathi et al 2019), although the bacteria has been confirmed to be widely spread in pigs in that province (Besung et al 2019). A large cluster of zoonotic transmission of S. suis in the province that has been reported (Tarini et al 2022) is considered unusual trough sharing common source of infected traditional food. Veterinary investigation in that cluster cases revealed that around 10% of pig tonsil specimens from private slaughtered houses were positive for S. suis (Tarini et al 2022).…”

Section: Introductionmentioning

confidence: 97%

“…A large cluster of zoonotic transmission of S. suis in the province that has been reported (Tarini et al 2022) is considered unusual trough sharing common source of infected traditional food. Veterinary investigation in that cluster cases revealed that around 10% of pig tonsil specimens from private slaughtered houses were positive for S. suis (Tarini et al 2022). All animals were without clinical symptoms.…”

Section: Introductionmentioning

confidence: 99%

Experimental Infection of Streptococcus suis Isolate in Pig in Bali – Indonesia Produced Mild Clinical Signs but Severe Multiorgan Lesions

2023

Int J Vet Sci

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There has been uncertainty about Streptococcus suis (S. suis) causing disease in pig. Different inoculation routes might lead to different pathologic courses. Here, we provide data on experimental infection of weaning pigs with S. suis isolated from pigs with severe infections through intranasal (IN) and intravenous (IV) inoculation. Nine weaning landrace piglets were used as experimental animals. Three were inoculated with S. suis intranasally and three intravenously, each with 1x109CFU S. suis, while the other three were left uninoculated as control animals. Prior to inoculation, the animals were anesthetized using ketamine hydrochloride (10mg/BW) delivered intramuscularly. All control animals remained healthy throughout the study. Fever was observed in all IN and IV animals from 3 to 9 days post infection (dpi). Appetite loss was observed at 3 to 9dpi in the IN group and at 3 to 7dpi in the IV group. Diarrhea occurred in one animal in each group from 3-5dpi. Lameness was observed for one animal in the IN group. Body weights (bwt) on Day 14 of the IN, IV, and control group piglets were 11.93±0.83, 9.80±1.83, and 14.70±0.53kg, respectively. After 14 days, only four animals, three from the IN group and one from the IV group, showed pathological lesions of pneumonia and hemorrhage in the myocardium. Necropsied animals from both inoculation route groups showed inflammation in various organs. Using polymerase chain reaction, we identified S. suis from the culture of heart samples taken from animals with hemorrhage in the myocardium. We concluded that although producing a mild clinical course, S. suis isolated from severely diseased pigs causes multiorgan histological lesion development and slower weight gain. Appropriate vaccines against S. suis should reduce its financial and zoonotic impact.

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A large cluster of human infections of Streptococcus suis in Bali, Indonesia

Cited by 6 publications

References 23 publications

Antibiotic Resistance Patterns and Molecular Characterization of Streptococcus suis Isolates from Swine and Humans in China

Antibiotic Resistance Patterns and Molecular Characterization of Streptococcus suis Isolates from Swine and Humans in China

Meningitis and sepsis caused by Streptococcus suis in an elderly woman: A CARE-compliant case report

Experimental Infection of Streptococcus suis Isolate in Pig in Bali – Indonesia Produced Mild Clinical Signs but Severe Multiorgan Lesions

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