A Large Aperture Ultrasonic Array System for Hyperthermia Treatment of Deep-Seated Tumors

Seppi, E.; Shapiro, Edward G.; Zitelli, L.; Henderson, S.; Wehlau, A.; Wu, Guoxing; Dittmer, C.

doi:10.1109/ultsym.1985.198652

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…Helios, a versatile, large-aperture ultrasonic array system, employing 30 focused beams and an ultrasonic imager, was developed at Varian Associates and placed at our institution for evaluation. Technical aspects of system design, and characterization of individual (single) transducer-lens units through measurement of ultrasonic field djstributions in water have been reported by Seppi et al (1985). Results of initial 'miniphantom' studies of performance characteristics of Helios have been reported by Nussbaum et al (1986).…”

Section: Introductionmentioning

confidence: 97%

Potential for localized, adjustable deep heating in soft-tissue environments with a 30-beam ultrasonic hyperthermia system

Nussbaum

Straube

Drag

et al. 1991

International Journal of Hyperthermia

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Initial heating rates (degrees C/min) along parallel tracks at depths of 1-14 cm in a static, muscle-like phantom were determined from time-temperature profiles obtained with 'Helios', a 30-beam ultrasonic hyperthermia system developed by Varian Associates. Data were taken at a single operating frequency of 556 kHz, for different sets of focal plane ring diameters of the four-ring array applicator, different levels of transducer driving power and two different focal plane depths, 6 cm and 9 cm. In each experiment, at each point of temperature measurement, analysis of temperature versus time data over a 2 min heating interval permitted separation of the desired phantom heating from artefactual heating resulting primarily from absorption of transverse (shear) waves produced at phantom-metal probe catheter interfaces. The results of the studies conducted suggest that in a non-translating carriage mode, Helios can produce axially and laterally localized deep heating in soft tissues for tissue volumes of lateral dimension up to a minimum of 4 cm and tissue depths of at least 11 cm. The results obtained also suggest that Helios can produce laterally localized heating to tissue depths of at least 11 cm without excessive heating of superficial soft-tissue layers, for tissue volumes of lateral dimension up to a minimum of 8 cm. The methodology used in the phantom studies was applied to the production of localized heating in the right lobe of the liver of adult pigs. Temperature versus time profiles obtained in the in vivo studies indicated that, for the set of system parameters employed, concentration of ultrasonic power at greater depths in the liver (e.g. 10.5 cm versus 5 cm) could be achieved, suggesting that Helios should be able to produce localized heating of targeted hepatic volumes when its operating parameters are selected in accordance with effective treatment planning techniques.

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Section: Introductionmentioning

confidence: 97%

Potential for localized, adjustable deep heating in soft-tissue environments with a 30-beam ultrasonic hyperthermia system

Nussbaum

Straube

Drag

et al. 1991

International Journal of Hyperthermia

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“…An alternative to these devices is the HELIOS ultrasound system [4], a rotating multi-transducer array which consists of 30 transducers arranged in four concentric rings mounted on an isospheric shell (Fig. 1).…”

Section: Introd Uctlonmentioning

confidence: 99%

An assessment of the deep heating capabilities of a rotating multi-transducer ultrasound hyperthermia system

Diederich¹,

Stauffer²

IEEE 1992 Ultrasonics Symposium Proceedings

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The HELIOS ultrasound system is a large aperture multitransducer array designed to heat deep-seated tumors for hyperthermia therapy of cancer. Previous studies in phantoms and animals have shown that the HELIOS can effectively heat large target regions up to 10-1 5 cm deep. The present effort describes the development of a treatment simulation program, which uses measured ultrasound beam data to calculate anticipated temperature distributions for various treatment configurations. This program was used to evaluate the effectiveness of the HELIOS applicator in its original configuration, and to investigate the potential improvement from proposed system modifications. Results from this program are presented in terms of practical heating strategies and pre-treatment planning schemes. INTROD UCTlONUltrasound is often the modality of choice for localizing heating energy at depth within tissue for hyperthermia cancer therapy. The large penetration depths and the ability to produce small focal zones with ultrasound energy in the frequency range of 0.5-1 .O MHz allows for preferential targeting of the tumor volume while sparing the surrounding normal tissues. In response to the clinical requirement for precise heating of heat deepseated tumors, several devices are currently under development or in clinical use. Scanned focused ultrasound systems (1-21 which mechanically scan a high intensity focal zone through the tumor volume have shown promising clinical results for tumors which are up to 10 cm deep in the pelvis and abdomen. More recent developments include phased array systems which can synthesize optimized field distributions as a means of improving target localization and avoiding bone and bowel gas [3].

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Ultrasonic phased array controller for hyperthermia applications

1991

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A Large Aperture Ultrasonic Array System for Hyperthermia Treatment of Deep-Seated Tumors

Cited by 6 publications

References 5 publications

Potential for localized, adjustable deep heating in soft-tissue environments with a 30-beam ultrasonic hyperthermia system

Potential for localized, adjustable deep heating in soft-tissue environments with a 30-beam ultrasonic hyperthermia system

An assessment of the deep heating capabilities of a rotating multi-transducer ultrasound hyperthermia system

Ultrasonic phased array controller for hyperthermia applications

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