A lanthanide nanocomposite with cross-relaxation enhanced near-infrared emissions as a ratiometric nanothermometer

Hu, Qian; Kong, Na; Chai, Yaqin; Xing, Zhenyu; Wu, Yukai; Zhang, Jieying; Li, Fuyou; Zhu, Xingjun

doi:10.1039/d2nh00283c

Cited by 19 publications

(20 citation statements)

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“…MDA-MB-231 is a highly aggressive, invasive, and poorly differentiated triple-negative breast cancer (TNBC) cell line, as it lacks estrogen receptor (ER) and progesterone receptor (PR) expression, as well as HER2 (human epidermal growth factor receptor 2) amplification . On the other hand, human embryonic kidney (HEK-293) cells have been chosen as a healthy cell model, previously used in the literature for toxicity studies on novel molecular or nanostructured compounds. , …”

Section: Resultsmentioning

confidence: 99%

“…51 On the other hand, human embryonic kidney (HEK-293) cells have been chosen as a healthy cell model, previously used in the literature for toxicity studies on novel molecular or nanostructured compounds. 52,53 Cell viability has been assessed after 2, 24, and 48 h of incubation with the three as-prepared core@shell NPs dispersions at different concentrations (ranging from 50 to 1000 μg mL −1 ). MTT assays reveal the maximum nontoxic concentration for each selected cell line.…”

Section: Chemical and Colloidal Stability Monitored By Uc Emissionmentioning

confidence: 99%

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From Nanothermometry to Bioimaging: Lanthanide-Activated KY₃F₁₀ Nanostructures as Biocompatible Multifunctional Tools for Nanomedicine

Cressoni

Vurro

Milan

et al. 2023

ACS Appl. Mater. Interfaces

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Lanthanide-activated fluoride-based nanostructures are extremely interesting multifunctional tools for many modern applications in nanomedicine, e.g., bioimaging, sensing, drug delivery, and photodynamic therapy. Importantly, environmental-friendly preparations using a green chemistry approach, as hydrothermal synthesis route, are nowadays highly desirable to obtain colloidal nanoparticles, directly dispersible in hydrophilic media, as physiological solution. The nanomaterials under investigation are new KY 3 F 10 -based citrate-capped core@shell nanostructures activated with several lanthanide ions, namely, Er 3+ , Yb 3+ , Nd 3+ , and Gd 3+ , prepared as colloidal water dispersions. A new facile microwaveassisted synthesis has been exploited for their preparation, with significant reduction of the reaction times and a fine control of the nanoparticle size. These core@shell multifunctional architectures have been investigated for use as biocompatible and efficient contrast agents for optical, magnetic resonance imaging (MRI) and computerized tomography (CT) techniques. These multifunctional nanostructures are also efficient noninvasive optical nanothermometers. In fact, the lanthanide emission intensities have shown a relevant relative variation as a function of the temperature, in the visible and near-infrared optical ranges, efficiently exploiting ratiometric intensity methods for optical thermometry. Importantly, in contrast with other fluoride hosts, chemical dissolution of KY 3 F 10 citrate-capped nanocrystals in aqueous environment is very limited, of paramount importance for applications in biological fluids. Furthermore, due to the strong paramagnetic properties of lanthanides (e.g., Gd 3+ ), and X-ray absorption of both yttrium and lanthanides, the nanostructures under investigation are extremely useful for MRI and CT imaging. Biocompatibility studies of the nanomaterials have revealed very low cytotoxicity in dfferent human cell lines. All these features point to a successful use of these fluoride-based core@shell nanoarchitectures for simultaneous diagnostics and temperature sensing, ensuring an excellent biocompatibility.

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Section: Resultsmentioning

confidence: 99%

Section: Chemical and Colloidal Stability Monitored By Uc Emissionmentioning

confidence: 99%

From Nanothermometry to Bioimaging: Lanthanide-Activated KY₃F₁₀ Nanostructures as Biocompatible Multifunctional Tools for Nanomedicine

Cressoni

Vurro

Milan

et al. 2023

ACS Appl. Mater. Interfaces

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“…The main challenges currently facing the field are: Heat Transfer at the Nanoscale : Despite the potential benefits of luminescence thermometry in uncovering heat transfer features at the nanoscale, only a few works have reported its use, [ 190,192,356 ] although the possibility is occasionally highlighted. [ 384 ] For instance, UCNPs can be engineered using a core–shell approach to place distinct Ln 3+ ions in distinct layers, allowing for the creation of purposefully built heterostructures. [ 385–389 ] This unique nanoarchitecture provides an opportunity to study heat propagation within the particles themselves and compare the unknown thermal dynamics at the nanoscale with the well‐understood heat transfer mechanisms in bulk materials.…”

Section: Discussionmentioning

confidence: 99%

Spotlight on Luminescence Thermometry: Basics, Challenges, and Cutting‐Edge Applications

et al. 2023

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Luminescence (nano)thermometry is a remote sensing technique that relies on the temperature dependency of the luminescence features (e.g., bandshape, peak energy or intensity, and excited state lifetimes and risetimes) of a phosphor to measure temperature. This technique provides precise thermal readouts with superior spatial resolution in short acquisition times. Although luminescence thermometry is just starting to become a more mature subject, it exhibits enormous potential in several areas, e.g., optoelectronics, photonics, micro‐ and nanofluidics, and nanomedicine. This work reviews the latest trends in the field, including the establishment of a comprehensive theoretical background and standardized practices. The reliability, repeatability, and reproducibility of the technique are also discussed, along with the use of multiparametric analysis and artificial‐intelligence algorithms to enhance thermal readouts. In addition, examples are provided to underscore the challenges that luminescence thermometry faces, alongside the need for a continuous search and design of new materials, experimental techniques, and analysis procedures to improve the competitiveness, accessibility, and popularity of the technology

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“…Lanthanide luminescence nanothermometers (LNTs) produce minute, extremely sensitive, and detectable optical signals for reporting temperature information, which is particularly beneficial in biomedicine to ensure reliable treatment and diagnosis [28]. Due to their distinctive optical characteristics, such as a large Stokes shift, spectrally sharp luminescence emissions, long luminescence lifetimes, and excellent photostability, lanthanide-doped luminescent nanoparticles with excitation and/or emission in the NIR range have recently attracted a lot of attention as one of the top candidates for noninvasive biological applications.…”

Section: Perspectives Of Nanotechnology and Medical Diagnosticsmentioning

confidence: 99%

Therapeutic Application of Nanomaterials in the Management of Health Care: 'An Updated Review'

Mishra¹,

Irum²,

Hussain³

et al. 2022

Int J Med Nano Res

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The provision of healthcare, which is a fundamental human right, has frequently been the subject of cutting-edge technology development. The availability of high-quality, timely, acceptable, and reasonably priced healthcare has greatly benefited from technological advancement. A new generation of nanostructures has emerged as a result of developments in nanoscience. They each have a distinct set of characteristics that contribute to their amazing uses. Since its debut, nanotechnology has had an ongoing impact on healthcare and has had a significant impact on its transformation, which has led to better results. Nanotechnology has advanced around the globe during the past two decades, and the process has been sped up by intensive study across many healthcare industries. Nanomedicine is the application of nanotechnology and related nanocarriers and nanosystems in medicine. It has proven to be extremely useful in illness detection, diagnosis, and therapy. Different nanosystems have been shown to make superior theranostic candidates than traditional ones. This review will provide an overview of medically relevant nanosystems, their uses, and their drawbacks in the fields of gene therapy, targeted medication delivery, cancer treatment, and other genetic illnesses. Despite having enormous potential, nanotechnology has not yet been fully utilized. To quickly transform the healthcare industry, more work needs to be put into overcoming these constraints and maximizing its potential.

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A lanthanide nanocomposite with cross-relaxation enhanced near-infrared emissions as a ratiometric nanothermometer

Abstract: Lanthanide luminescence nanothermometers (LNTs) provide microscopic, highly sensitive, and visualizable optical signals for reporting temperature information, which is particularly useful in biomedicine to achieve precise diagnosis and therapy. However, LNTs...

Cited by 19 publications

References 61 publications

From Nanothermometry to Bioimaging: Lanthanide-Activated KY₃F₁₀ Nanostructures as Biocompatible Multifunctional Tools for Nanomedicine

From Nanothermometry to Bioimaging: Lanthanide-Activated KY₃F₁₀ Nanostructures as Biocompatible Multifunctional Tools for Nanomedicine

Spotlight on Luminescence Thermometry: Basics, Challenges, and Cutting‐Edge Applications

Therapeutic Application of Nanomaterials in the Management of Health Care: 'An Updated Review'

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A lanthanide nanocomposite with cross-relaxation enhanced near-infrared emissions as a ratiometric nanothermometer

Abstract: Lanthanide luminescence nanothermometers (LNTs) provide microscopic, highly sensitive, and visualizable optical signals for reporting temperature information, which is particularly useful in biomedicine to achieve precise diagnosis and therapy. However, LNTs...

Cited by 19 publications

References 61 publications

From Nanothermometry to Bioimaging: Lanthanide-Activated KY3F10 Nanostructures as Biocompatible Multifunctional Tools for Nanomedicine

From Nanothermometry to Bioimaging: Lanthanide-Activated KY3F10 Nanostructures as Biocompatible Multifunctional Tools for Nanomedicine

Spotlight on Luminescence Thermometry: Basics, Challenges, and Cutting‐Edge Applications

Therapeutic Application of Nanomaterials in the Management of Health Care: 'An Updated Review'

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Product

Resources

About

From Nanothermometry to Bioimaging: Lanthanide-Activated KY₃F₁₀ Nanostructures as Biocompatible Multifunctional Tools for Nanomedicine

From Nanothermometry to Bioimaging: Lanthanide-Activated KY₃F₁₀ Nanostructures as Biocompatible Multifunctional Tools for Nanomedicine