A label-free electrochemical immunosensor for the detection of cancer biomarker α-fetoprotein (AFP) based on hydroxyapatite induced redox current

Sun, Jisan; Tian, Dazhi; Guo, Qingjun; Zhang, Li; Jiang, Wentao; Yang, Minghui

doi:10.1039/c6ay02555b

Cited by 32 publications

(5 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table 1 Assay results of AFP in serum samples Table 2 shows the analytical performance of other methods for AFP detection. This new one-step detection method has a low (Limit of Detection) LOD and wide range of detection similar to or better than previously reported ways [36][37][38][39][40][41] . However, the system provides cost-effective testing with a simple measuring process.…”

Section: Detection Of Afp In Human Serum Samplessupporting

confidence: 77%

Preparation of gold nanoparticle coated NaYF₄:Yb,Er,Gd nanoparticles and their application for AFP detection in the red region

Zhang

Wang

et al. 2017

Anal. Methods

View full text Add to dashboard Cite

show abstract

Section: Detection Of Afp In Human Serum Samplessupporting

confidence: 77%

Preparation of gold nanoparticle coated NaYF₄:Yb,Er,Gd nanoparticles and their application for AFP detection in the red region

Zhang

Wang

et al. 2017

Anal. Methods

View full text Add to dashboard Cite

show abstract

“…Finally, the practical applicability of the aptasensor was verified by analyzing human serum samples using the standard addition method. 112 Carbon nanotubes (CNTs).-Because of their special qualities, CNTs (Fig. 6) can be used to create highly sensitive and stable biosensors for detecting AFP.…”

Section: Experimental Issues In Afp Detectionmentioning

confidence: 99%

Review—Electrochemical Biosensors for Alpha-Fetoprotein Detection: Recent Advances and Future Perspectives

Raziyan,

Palevicius,

Janusas

2024

J. Electrochem. Soc.

View full text Add to dashboard Cite

Given the multitude of global health concerns, it is crucial to promptly and precisely identify biomarkers like alpha-fetoprotein (AFP) in order to facilitate the early identification and treatment of diverse illnesses, with a special emphasis on cancer. Conventional detection techniques often exhibit limitations in terms of intricacy, temporal requirements, and ease of use, underscoring the pressing want for inventive resolutions. The use of electrochemical biosensors has shown great potential in the field of AFP detection, because they provide efficient, highly responsive, and economically viable detection capabilities. This study examines current advancements in electrochemical biosensors specifically designed for the detection of alpha-fetoprotein (AFP), with a focus on the incorporation of state-of-the-art materials, sophisticated manufacturing methods, and novel biorecognition approaches. This study seeks to meet the urgent need for dependable and easily available diagnostic tools in the worldwide battle against cancer and other illnesses by offering a thorough examination of the current advancements in electrochemical biosensors. By making progress in AFP detection technologies, our goal is to have a positive impact on healthcare outcomes, improve illness management, and eventually reduce the global burden of disease.

show abstract

“…Vennila et al employed an environmentally friendly method for synthesizing silver-doped cerium oxide nanoparticles for electrochemical glucose detection [21]. They demonstrated that the current amplifies and produces a measurable amount of electrocatalytic current due to the generation of H 2 O 2 by the glucose oxidase enzyme.…”

Section: Introductionmentioning

confidence: 99%

A simple, sensitive, label-free electrochemical immunosensor based on the chitosan-coated silver/cerium oxide (CS@Ag/CeO₂) nanocomposites for the detection of alpha-fetoprotein (AFP)

et al. 2023

View full text Add to dashboard Cite

Metal oxide-based sensors have the benefit of inexpensive, quick response, and high sensitivity in detecting specific biological species. In this article, a simple electrochemical immunosensor was fabricated using antibody-chitosan coated silver/cerium oxide (Ab-CS@Ag/CeO2) nanocomposites on a gold electrode for sensitive alpha-fetoprotein (AFP) diagnosis in human serum samples. Successfully synthesis of AFP antibody-CS@Ag/CeO2 conjugates was confirmed through FTIR spectra of the product. The amine coupling bond chemistry was then used to immobilize the resultant conjugate on a gold electrode surface. It was observed that the interaction of the synthesized Ab-CS@Ag/CeO2 nanocomposites with AFP prevented an electron transfer and reduced the voltammetric Fe(CN)63-/4- peak current, which was proportional to the amount of AFP. The linear ranges of AFP concentration were found from 10-12-10-6 gmL-1. The limit of detection was calculated using the calibration curve and came out to be 0.57pgmL-1. The designed label-free immunosensor successfully detected AFP in human serum samples. As a result, the resulting immunosensor is a promising sensor plate form for AFP detection and could be used in clinical bioanalysis.

show abstract

A label-free electrochemical immunosensor for the detection of cancer biomarker α-fetoprotein (AFP) based on hydroxyapatite induced redox current

Abstract: An electrochemical immunosensor for label-free detection of cancer biomarker α-fetoprotein (AFP) was developed based on hydroxyapatite (HAP) nanoparticles.

Cited by 32 publications

References 38 publications

Preparation of gold nanoparticle coated NaYF₄:Yb,Er,Gd nanoparticles and their application for AFP detection in the red region

Preparation of gold nanoparticle coated NaYF₄:Yb,Er,Gd nanoparticles and their application for AFP detection in the red region

Review—Electrochemical Biosensors for Alpha-Fetoprotein Detection: Recent Advances and Future Perspectives

A simple, sensitive, label-free electrochemical immunosensor based on the chitosan-coated silver/cerium oxide (CS@Ag/CeO₂) nanocomposites for the detection of alpha-fetoprotein (AFP)

Contact Info

Product

Resources

About

A label-free electrochemical immunosensor for the detection of cancer biomarker α-fetoprotein (AFP) based on hydroxyapatite induced redox current

Abstract: An electrochemical immunosensor for label-free detection of cancer biomarker α-fetoprotein (AFP) was developed based on hydroxyapatite (HAP) nanoparticles.

Cited by 32 publications

References 38 publications

Preparation of gold nanoparticle coated NaYF4:Yb,Er,Gd nanoparticles and their application for AFP detection in the red region

Preparation of gold nanoparticle coated NaYF4:Yb,Er,Gd nanoparticles and their application for AFP detection in the red region

Review—Electrochemical Biosensors for Alpha-Fetoprotein Detection: Recent Advances and Future Perspectives

A simple, sensitive, label-free electrochemical immunosensor based on the chitosan-coated silver/cerium oxide (CS@Ag/CeO2) nanocomposites for the detection of alpha-fetoprotein (AFP)

Contact Info

Product

Resources

About

Preparation of gold nanoparticle coated NaYF₄:Yb,Er,Gd nanoparticles and their application for AFP detection in the red region

Preparation of gold nanoparticle coated NaYF₄:Yb,Er,Gd nanoparticles and their application for AFP detection in the red region

A simple, sensitive, label-free electrochemical immunosensor based on the chitosan-coated silver/cerium oxide (CS@Ag/CeO₂) nanocomposites for the detection of alpha-fetoprotein (AFP)