A label-free electrochemical aptasensor for breast cancer cell detection based on a reduced graphene oxide-chitosan-gold nanoparticle composite

O Uso De Luteína E Zeaxantina Como Corantes Intraoculares Para Cirurgia Oftalmológica

“…Dependendo do tipo de transdutor ou de acordo com a natureza da resposta biológica, os biossensores podem ser eletroquímicos, piezoelétricos e ópticos (HASAN et al, 2021). Os biossensores eletroquímicos têm sido amplamente explorados na detecção do câncer (FELIX;ANGNES, 2018;GIANG et al, 2021;NUR et al, 2021;SHAFIEI et al, 2021;TABISH et al, 2021). Em geral utilizam transdutores a base de materiais condutores e semicondutores como ouro, carbono e platina (SONG et al, 2018;BUK;PEMBLE, 2019;JIMÉNEZ-FIÉRREZ et al, 2020).…”

“…Diversos nanomateriais fornecem superfícies biocompatíveis para imobilização de elementos biológicos, ajudando a reter as biomoléculas com alta estabilidade (FELIX; ANGNES, 2018). Têm sido utilizados nanopartículas de ouro (SHAFIEI et al, 2021), nanomateriais de carbono (SHEKARI et al, 2021), nanopartículas magnéticas (WANG et al, 2021) e quantum dots (TABISH et al, 2021). Além disso, a modificação do eletrodo com materiais que promovem o aumento da área de superfície pode elevar sua sensibilidade e fazer com que atinjam menores limites de detecção (FELIX; ANGNES, 2018).…”

Breast Cancer Aptamers: Current Sensing Targets, Available Aptamers, and Their Evaluation for Clinical Use in Diagnostics

“…Aptamer AS1411, previously referred to as AGRO100, is the only available aptamer for the detection of nucleolin [57]. AS1411 has been used to detect cell lines MCF-7 [58,59] and MDA-MB-231 [60], but more work should be done to assess the use of the aptamer in real tissue samples. Unlike many other aptamers, AS1411 was not developed using the SELEX process; instead, it was developed with a focus on function over form and based on previous studies that showed the anti-proliferation effects of guanine rich oligionucleotides [61].…”

Electrochemical biosensing based on folic acid-triazine-grafted reduced graphene oxide: a highly selective breast cancer cell sensor

“…[1][2][3][4][5][6][7][8][9][10][11][12] Thus far, graphenes and their derivatives have gained importance due to their excellent properties such as large interaction surface, good conductivity, optical properties and catalytic abilities, and are widely used in biosensors. [12][13][14] Interestingly, graphene-based electrochemical sensors are now recognized as reliable and high-reliability tools for cancer detection. This is understandable because these materials with a structure containing graphenes in cell detection sensors provide the necessary ability to develop properties that create rich sites for binding receptors, electrochemically leading to a highly selective function for them.…”

“…According to reports, many useful graphene-based sensors have been developed to measure and identify cancer cells under different conditions and different antibodies or target molecules. [13][14][15] In addition, folate receptors (FRs) are frequently used as markers in the electrochemical detection of breast cancer cells (Fig. 1) and can be adopted by various cancer cells, while their detection by normal cells is limited.…”